Metastatic Spinal Cord Compression by Solid Tumors

Abstract

As the survival of cancer patients continues to improve, physicians in the 21st century face the challenge of early detection of metastatic spinal cord compression. Prompt diagnosis and intervention increase the likelihood of functional recovery. Because the epidural space is the most common site of spinal cord metastasis from solid tumors, this article will review the epidemiology, relevant anatomy, pathophysiology, clinical presentation, diagnostic evaluation, treatment, and prognosis for metastatic epidural spinal cord compression. Special attention will be given to the various modalities available for management of metastatic epidural spinal cord compression to maintain or restore normal spinal cord function and relieve pain. These treatment options will be considered according to patients' disease burden, life expectancy, and values. Intramedullary metastasis will be briefly discussed.

Spinal Cord Compression in Childhood Pediatric Malignancies

“…7 It considered as a major cause of morbidity in children with systemic malignancy, 8 that range from minor sensory, motor, and autonomic changes to severe pain and complete paralysis that significant affects the patient's quality of life. 9 To assess the magnitude of MSCC management problem, we evaluated 24 children with MSCC who represented the entire group of patients with MSCC registered at the 3 participating centers.…”

Incidence and outcome of bone metastatic disease at University Malaya Medical Centre

“…Osteoblastic or osteosclerotic lesions are commonly seen in carcinomas of the prostate and breast. (21) Pathological fractures are commonly seen in patients with breast cancer due to the mainly lytic nature of the lesions. They are, however, infrequently seen in patients with lung and prostate cancers, as the survival rate is short in the former and the lesions are mainly osteoblastic in the latter.…”

Waldenstrom's macroglobulinemia presenting with spinal cord compression: A case report

“…Epidural metastasis causing spinal cord compression in lymphoid neoplasms is well described [5]; this however has not been reported in the context of WM. We report an unusual case of epidural spinal cord compression as the initial presentation of underlying WM.…”