Incidence and outcome of bone metastatic disease at University Malaya Medical Centre

Singh, Vivek Ajit; Haseeb, Amber; Alkubaisi, Alla Allden H Ali

doi:10.11622/smedj.2014138

Cited by 20 publications

(17 citation statements)

References 34 publications

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“…Pathological fractures commonly occur in patients with bone metastasis from breast cancer and this is mainly due to the lytic nature of bone lesions. [16] In our series, 8 (7.14%) patients presented with pathological fracture during follow-up.…”

Section: Discussionmentioning

confidence: 53%

Radiation Therapy– An Effective Tool for Analgesia in Metastatic Bone Disease in Breast Cancer

Negi¹,

Kingsley²,

Sachdeva³

et al. 2017

jemds

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Section: Discussionmentioning

confidence: 53%

Radiation Therapy– An Effective Tool for Analgesia in Metastatic Bone Disease in Breast Cancer

Negi¹,

Kingsley²,

Sachdeva³

et al. 2017

jemds

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“…Additionally, certain sites of metastatic disease appear to predispose for a worse prognosis [7]. Several authors have reported that the presence of bone metastasis (BM) is one of those adverse prognostic factors with a median OS of 12 months [8][9][10]. Aim of this study was to analyze patients with BM for oncologic outcome according to treatment type in the era of TT.…”

Section: Introductionmentioning

confidence: 99%

Survival and prognostic factors of patients with renal cell cancer with bone metastasis in the era of targeted therapy: A single-institution analysis

Pahernik

Hadaschik

et al. 2016

Urologic Oncology: Seminars and Original Investigations

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“…Due to the axial skeleton containing a higher percentage of red bone marrow, it is a more common target site, to which tumors metastasize as compared with the appendicular skeleton. The main afflicted areas include the ribs, pelvis, and spine, with partial metastasis through the Batson venous plexus, which bypasses the lung circulation [15]. The most critical form of metastasis, observed in 85% of patients, occurs via an indirect route, through which an initial haematogenous metastasis traverses to the vertebral body [16].…”

Section: Introductionmentioning

confidence: 99%

Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies

Jiang

Ding

et al. 2016

Journal of Nanomaterials

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Malignant spinal tumors, categorized into primary and metastatic ones, are one of the most serious diseases due to their high morbidity and mortality rates. Common primary spinal tumors include chordoma, chondrosarcoma, osteosarcoma, Ewing’s sarcoma, and multiple myeloma. Spinal malignancies are not only locally invasive and destructive to adjacent structures, such as bone, neural, and vascular structures, but also disruptive to distant organs (e.g., lung). Current treatments for spinal malignancies, including wide resection, radiotherapy, and chemotherapy, have made significant progress like improving patients’ quality of life. Among them, chemotherapy plays an important role, but its potential for clinical application is limited by severe side effects and drug resistance. To ameliorate the current situation, various polymer nanoparticles have been developed as promising excipients to facilitate the effective treatment of spinal malignancies by utilizing their potent advantages, for example, targeting, stimuli response, and synergetic effect. This review overviews the development of polymer nanoparticles for antineoplastic delivery in the treatment of spinal malignancies and discusses future prospects of polymer nanoparticle-based treatment methods.

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Incidence and outcome of bone metastatic disease at University Malaya Medical Centre

Cited by 20 publications

References 34 publications

Radiation Therapy– An Effective Tool for Analgesia in Metastatic Bone Disease in Breast Cancer

Radiation Therapy– An Effective Tool for Analgesia in Metastatic Bone Disease in Breast Cancer

Survival and prognostic factors of patients with renal cell cancer with bone metastasis in the era of targeted therapy: A single-institution analysis

Polymer Nanoparticle-Based Chemotherapy for Spinal Malignancies

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