Metastatic spermatocytic seminoma. A case report with light microscopic, ultrastructural, and immunohistochemical findings

Matoŝka, J; Ondruš, D; Horňák, M

doi:10.1002/1097-0142(19880915)62:6<1197::aid-cncr2820620626>3.0.co;2-a

Cited by 54 publications

(25 citation statements)

References 12 publications

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“…Few spermatocytic seminomas have been studied at the ultrastructural level [1,34,46,54,60]. The general ultrastructural features of the neoplastic cells of the specimen described in this paper confirm previous reports, except for the presence in the cytoplasm of both intermitochondrial cement and free nuage.…”

Section: Discussionsupporting

confidence: 84%

Intermitochondrial cement (nuage) in a spermatocytic seminoma: comparison with classical seminoma and normal testis

et al. 2008

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The nuage, an ultrastructural marker of normal human germ cells (spermatogonia type A and primary spermatocytes), may be found associated with mitochondria (intermitochondrial cement) and/or free in the cytoplasm. Eight specimens from germ cell-related tumours were reviewed to assess whether the nuage could have diagnostic significance in testicular neoplasms. The nuage of neoplastic cells from seven classical seminomas and one spermatocytic seminoma was compared with that from two normal testes. The ultrastructural study demonstrated that only spermatocytic seminoma cells contained both types of nuage and that significantly fewer spermatocytic seminoma cells (28%) contained intermitochondrial cement compared with control spermatogonia type A (81.1%) and primary spermatocytes (47.6%). The data indicate that (1) the detection of the nuage confirms that the phenotype of spermatocytic seminoma is more differentiated than that of classical seminoma; (2) the intermitochondrial cement is an additional example of how a distinctive organelle of a normal cell is preserved in its neoplastic counterpart and (3) if the intermitochondrial cement were found in other cases of spermatocytic seminoma, this organelle of the normal germ cell lineage could be considered as a new ultrastructural marker of the neoplasm.

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Section: Discussionsupporting

confidence: 84%

Intermitochondrial cement (nuage) in a spermatocytic seminoma: comparison with classical seminoma and normal testis

et al. 2008

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“…42 It is important to distinguish spermatocytic seminoma from classic seminoma, because spermatocytic seminoma almost never metastasizes (except if there is a sarcomatous component). 43,44 Patients usually do not benefit from an adjuvant therapy after orchiectomy. Typically, there is no intratubular germ cell neoplasia unclassified neighboring spermatocytic seminoma.…”

Section: Discussionmentioning

confidence: 99%

Cancer testis antigen expression in testicular germ cell tumorigenesis

et al. 2014

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Cancer testis antigens are encoded by germ line-associated genes that are present in normal germ cells of testis and ovary but not in differentiated tissues. Their expression in various human cancer types has been interpreted as 're-expression' or as intratumoral progenitor cell signature. Cancer testis antigen expression patterns have not yet been studied in germ cell tumorigenesis with specific emphasis on intratubular germ cell neoplasia unclassified as a precursor lesion for testicular germ cell tumors. Immunohistochemistry was used to study MAGEA3, MAGEA4, MAGEC1, GAGE1 and CTAG1B expression in 325 primary testicular germ cell tumors, including 94 mixed germ cell tumors. Seminomatous and non-seminomatous components were separately arranged and evaluated on tissue microarrays. Spermatogonia in the normal testis were positive, whereas intratubular germ cell neoplasia unclassified was negative for all five CT antigens. Cancer testis antigen expression was only found in 3% (CTAG1B), 10% (GAGE1, MAGEA4), 33% (MAGEA3) and 40% (MAGEC1) of classic seminoma but not in nonseminomatous testicular germ cell tumors. In contrast, all spermatocytic seminomas were positive for cancer testis antigens. These data are consistent with a different cell origin in spermatocytic seminoma compared with classic seminoma and support a progression model with loss of cancer testis antigens in early tumorigenesis of testicular germ cell tumors and later re-expression in a subset of seminomas.

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“…A debulking lymph node dissection was performed followed by a radiotherapy and a combination chemotherapy. The patient died from the side effects of chemotherapy [9].…”

Section: Discussionmentioning

confidence: 99%

Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma

Horn¹,

Schulz

Maurer³

et al. 2010

Med Oncol

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Metastatic spermatocytic seminoma is an extremely rare disease. No chemotherapeutic regimen is established and the use of adjuvant radiation therapy after orchiectomy as frequently performed for classical seminoma is unclear. We report the third case of proven spermatocytic seminoma metastatic in the literature and provide a review of the literature. Administering BEP polychemotherapy as in classical seminoma was poorly effective in reducing the retroperitoneal mass in a patient with spermatocytic seminoma. A review of the literature showed that all the three described patients developing metastatic disease did not receive adjuvant radiation therapy after orchiectomy, which might be considered in high-risk cases.

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Metastatic spermatocytic seminoma. A case report with light microscopic, ultrastructural, and immunohistochemical findings

Cited by 54 publications

References 12 publications

Intermitochondrial cement (nuage) in a spermatocytic seminoma: comparison with classical seminoma and normal testis

Intermitochondrial cement (nuage) in a spermatocytic seminoma: comparison with classical seminoma and normal testis

Cancer testis antigen expression in testicular germ cell tumorigenesis

Poor efficacy of BEP polychemotherapy in metastatic spermatocytic seminoma

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