Metastatic small-cell carcinoma of the cervix during pregnancy

Canto, M. J.; Pons, Núria Toledo; Mendez, Inmaculada; Reus, A.; Pérez, F.

doi:10.3109/01443615.2013.845550

Cited by 4 publications

(5 citation statements)

References 6 publications

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“…The longest survivor was for 84 months [4]. The poorest outcome was of woman who died one month after diagnosis as stage IV-B [17]. Only one patient had family history of cancer.…”

Section: Discussionmentioning

confidence: 99%

Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Pan

Liu

Sheng

et al. 2019

Case Reports in Obstetrics and Gynecology

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Small cell neuroendocrine carcinoma of the cervix is a rare subtype of cervical cancer. Here we report a case in which a 27-year-old female patient presented at 34-week gestation with abnormal vaginal bleeding, underwent normal labor, and gave birth to a healthy neonate. Her pregnancy was complicated with a cervical tumor which turned out to be small cell neuroendocrine cervical carcinoma. We reviewed and discussed the features, diagnosis, and prognosis of small cell neuroendocrine carcinoma of the cervix.

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“…The longest survivor was for 84 months [4]. The poorest outcome was of woman who died one month after diagnosis as stage IV-B [17]. Only one patient had family history of cancer.…”

Section: Discussionmentioning

confidence: 99%

Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Pan

Liu

Sheng

et al. 2019

Case Reports in Obstetrics and Gynecology

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“…Few conclusions can be drawn from case reports relating to cervical cancer of rare histology diagnosed during pregnancy. In decreasing frequency order, we retrieved cases about treating neuroendocrine carcinomas [97,113,120,121,[136][137][138][139][140][149][150][151][152][153][154], clear cell carcinomas [134,135,155], and sarcoma [98].…”

Section: Rare Histological Typesmentioning

confidence: 99%

“…Most patients diagnosed with neuroendocrine tumors at the first or early second trimester of pregnancy underwent termination of pregnancy [121,136,151,154] to prevent any delay in cancer management. Three out of fifteen patients were diagnosed with stage FIGO 2018 IVB disease and died within months after the diagnosis [137,150,152]. Three additional patients diagnosed with localized disease died from either lung or liver metastases in less than a year [113,137,140], demonstrating the particularly poor prognosis of this disease.…”

Section: Rare Histological Typesmentioning

confidence: 99%

“…Among the 27 patients undergoing vaginal delivery [68,86,94,99,107,113,115,140,150,[157][158][159][160][161][162][163][164][165], 9 patients experienced recurrence at the episiotomy site [86,115,157,158,[162][163][164][165]. In other situations, cervical cancer was revealed by metastasis at the episiotomy site several months after delivery, having remained occult during the pregnancy [157,162,164,[166][167][168][169][170].…”

Section: Obstetrical Management Planned Deliverymentioning

confidence: 99%

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Cervical Cancer Associated with Pregnancy: Current Challenges and Future Strategies

Le Guévelou,

Selleret,

Laas

et al. 2024

Cancers

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Cancer during pregnancy is defined as a tumor diagnosed in a pregnant woman or up to 1-year post-partum. While being a rare disease, cervical cancer is probably one of the most challenging medical conditions, with the dual stake of treating the cancer without compromising its chances for cure, while preserving the pregnancy and the health of the fetus and child. To date, guidelines for gynecological cancers are provided through international consensus meetings with expert panels, giving insights on both diagnosis, treatment, and obstetrical care. However, these expert guidelines do not discuss the various approaches than can be found within the literature, such as alternative staging modalities or innovative surgical approaches. Also, the obstetrical care of women diagnosed with cervical cancer during pregnancy requires specific considerations that are not provided within our current standard of care. This systematic review aims to fill the gap on current issues with regards to the management of cervical cancer during pregnancy and provide future directions within this evolving landscape.

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“…In this study, 80 patients (86.96%) underwent the procedure, among whom 39 received neoadjuvant chemotherapy before the operation. From the literature collected, 19 patients (20.65%) were found to have lymphatic metastasis (30,33,34). Eight patients received 2-4 cycles of adjuvant chemotherapy either combined with lymphadenectomy during the second and third trimester.…”

Section: Treatment Modalitiesmentioning

confidence: 99%

Treatment and clinical outcomes of cervical cancer during pregnancy

et al. 2019

Ann. Transl. Med

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Background: This study aims to investigate clinicopathological factors associated with survival rate and treatment of patients with cervical cancer during pregnancy (CCP). Methods: A total of 92 patients diagnosed CCP were retrospectively reviewed. One patient was from Nanfang Hospital of Southern Medical University, 5 patients were from Tongji Hospital, and 86 patients were from case reports in the PubMed database from 1961 to 2019. Patients and tumor characteristics were evaluated. Kaplan-Meier and Cox regression methods were used to analyze the 5-year disease-specific survival (DSS).Results: Most patients (73 cases) were stage I according to the 2018 International Federation of Gynecology and Obstetrics (FIGO) standards. Twelve patients (13.04%) terminated pregnancy once diagnosed. These patients were diagnosed at the mean gestational age (GA) of 11±3 weeks, during early pregnancy. For the rest of the patients (80 cases) who continued pregnancy, the mean GA was 35±2 weeks at delivery. There was a significant difference in survival whether the treatment was performed once diagnosed or not. The 5-year DSS was 75% in adenocarcinoma (AC), 68.5% in squamous cell carcinoma (SCC), and 43.7% in the rare subtype. Among the 38 patients who underwent neoadjuvant chemotherapy (NACT), one patient suffered from spontaneous abortion, and one baby experienced acute myeloid leukemia (AML) ex-FAB (French-American-British)-M7 subtype and received bone marrow transplantation. Other delivered newborns showed no abnormality or malformation. Cox multi-factorial analysis demonstrated that tumor size (2 cm) was an independent overall survival predictor for CCP patients (P<0.05).Conclusions: Tumor size was an independent prognostic factor of survival in CCP patients. Pregnancy has adverse effects on the prognosis of cervical cancer. Personalized treatment is a priority for CCP patients.

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Metastatic small-cell carcinoma of the cervix during pregnancy

Cited by 4 publications

References 6 publications

Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Small Cell Neuroendocrine Carcinoma of the Cervix in Pregnancy: A Case Report and Review

Cervical Cancer Associated with Pregnancy: Current Challenges and Future Strategies

Treatment and clinical outcomes of cervical cancer during pregnancy

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