Metastatic renal cell carcinoma to stomach

Sullivan, Walter G.; Cabot, Edmund B.; Donohue, Robert E.

doi:10.1016/0090-4295(80)90473-2

Cited by 44 publications

(9 citation statements)

References 5 publications

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“…Large autopsy series reported by different authors have not found any kidney metastases in the stomach [4,5]. Few cases of gastric metastases of RCC have been described in the literature [6][7][8][9][10][11][12][13][14][15]. In the majority of these cases, metastases often start as a submucosal lesion, single or multiple, grossly polypoid or plaque-like.…”

Section: Discussionmentioning

confidence: 97%

Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma

et al. 2010

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A 75-year-old-man, with a 2-month history of abdominal pain, underwent a standard diagnostic workup that included a CT scan that showed a large right renal mass and subcentimeter nodes in the right and left lung lobes. In December 2003, the patient underwent right nephrectomy with adrenalectomy and a diagnosis of renal cell carcinoma (pT3N0M0 stage) was made. No further treatment was proposed and patient was followed up regularly. In October 2006, the annual gastrointestinal endoscopy showed asymptomatic multilobulated and polypoid masses in the gastric fundus and gastric body that corresponded to metastasis of the renal carcinoma that had been resected three years ago. Surgical treatment was refused and oral treatment with sunitinib (50 mg/day consecutively for 4 weeks followed by 2 weeks off) was initiated. Patient completed one cycle and development of acute toxicity (grade 3 asthenia, anorexia and mucositis) led to treatment interruption. After recovering from acute toxicity, the patient was proposed to reinitiate treatment with dose reduction, but he refused any medical treatment. At the follow-up visit, three months later, the gastrointestinal endoscopy showed four unspecific 2 mm nodules without malignant evidence. The whole-body CT did not reveal any other abnormality except for the known lung nodes. PET scan six months after treatment confirmed complete gastric response.

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Section: Discussionmentioning

confidence: 97%

Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma

et al. 2010

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“…The reference lists of the articles identified in this manner were then manually searched to identify any additional references and articles published only in abstract form were excluded. From this search, we identified 22 cases of gastric metastases arising from RCC (1,5,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Methodsmentioning

confidence: 99%

Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

et al. 2012

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Abstract. We analyzed the clinicopathological characteristics and therapeutic outcomes of patients with metastatic gastric tumors arising from renal cell carcinoma (RCC) to identify post-therapy prognostic factors. A total of 22 patients who were treated for metastatic gastric tumors arising from RCC were included in the study. A retrospective review was performed on the clinical characteristics of this disease. The median time interval from radical excision of the primary tumor to the detection of gastric metastasis (IGM) was 6.3 years. The overall 1-and 3-year survival rates were 52.6 and 21.0%, respectively, and the median survival time was 19 months. Compared with patients with an IGM of <6.3 years, patients with an IGM of ≥6.3 years showed a significantly longer median survival time (5 vs. 24 months; P=0.017). The median tumor size was significantly greater in patients with multiple metastases compared with those with solitary metastasis (4 vs. 2 cm; P=0.036). The incidence of patients who had undergone therapeutic tumor resection was significantly higher in patients with solitary metastasis compared with those with multiple metastases (100.0 vs. 35.7%; P=0.019). The appearance of gastric tumors in patients with a history of RCC should prompt the clinician to investigate the possibility of metastasis even several years after detection of the original renal cancer. A longer interval from nephrectomy to the diagnosis of gastric metastasis is generally indicative of a better prognosis, most likely the result of less aggressive tumor growth.

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“…Although typical sites of RCC metastasis are the lung, bones, liver, lymph nodes, or adrenal glands, RCC metastasis to the stomach is quite a rare condition, and few case reports have been presented so far. When a PubMed search was performed to identify case reports written in English and published within the past three decades using the keywords “renal cell carcinoma,” “metastasis,” and “stomach,” only 31 case reports (excluding our case) and case series reports were detected [5–35]. Of those, as a larger case series repot, Sakurai et al [26] entered details of 22 cases reported during a period from 2008 to 2012.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous resection of gastric and gallbladder metastasis from renal cell carcinoma treated by laparoscopic and endoscopic cooperative surgery: a case report

et al. 2019

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Background Metastases to the stomach or gallbladder from any malignancy is rarely noted, and simultaneous metastases to both organs are atypical. We present a unique case of simultaneous multifocal metastases of the stomach and gallbladder from renal cell carcinoma (RCC). Case presentation The case involved a 60-year-old man, with a past history of RCC (clear cell type, G2, T1b N0 M0 Stage I) treated by a right nephrectomy. Three years after the nephrectomy, a routine gastrointestinal endoscopy found an ulcerative lesion in the greater curvature of the gastric body. The gastric tumor was pathologically proven to be a metastasis from RCC. Furthermore, computed tomography incidentally revealed a mass lesion in the fundus of the gallbladder, which was also diagnosed as a potential metastasis from RCC. As endoscopic ultrasonography of the gastric tumor suggested the tumor potentially invaded to the submucosal layer, gastric wedge resection via a laparoscopic and endoscopic cooperative surgery (LECS) technique was applied to the gastric tumor, and laparoscopic cholecystectomy to the gallbladder tumor was simultaneously performed. Histological examination confirmed that the tumors of the stomach and gallbladder were both metastatic RCC. The hospitalization period after surgery was not eventful, and the patient was discharged on postoperative day 7. Thereafter, the patient required examination every 3 months, did not use anticancer agents, and has survived without relapse to 9 months after the surgery. Conclusions For patients with locally resectable RCC metastases, complete metastasectomy may bring long-term tumor control. Moreover, LECS for gastric metastasis is a reasonable approach for minimal invasiveness and an oncologically feasible outcome.

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Metastatic renal cell carcinoma to stomach

Cited by 44 publications

References 5 publications

Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma

Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma

Metastatic gastric tumors arising from renal cell carcinoma: Clinical characteristics and outcomes of this uncommon disease

Simultaneous resection of gastric and gallbladder metastasis from renal cell carcinoma treated by laparoscopic and endoscopic cooperative surgery: a case report

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