Metastatic Renal Cell Carcinoma to the Orbit and the Ethmoid Sinus

Jung, Jee Woong; Yoon, Sang Chul; Han, Dae Heon; Chi, Mijung

doi:10.1097/scs.0b013e31824cdb31

Cited by 12 publications

(11 citation statements)

References 7 publications

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“…Although metastases of RCC to the nose and paranasal sinus seems rare, they are most common secondary malignancies therein . A review of 98 paranasal sinus metastases revealed that RCC comprised 54% of the primary tumors with a predilection for the maxillary antrum (36%), ethmoidal sinuses (25%), frontal sinus (17%), and nasal cavity (11%) …”

Section: Primary Tumor Sitesmentioning

confidence: 99%

Metastases to nasal cavity and paranasal sinuses

et al. 2016

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The sinonasal cavities are rare locations for metastases. Metastases to these locations are usually solitary and produce similar symptoms to those of a primary sinonasal tumor. Nasal obstruction and epistaxis are the most frequent symptoms. The maxillary sinus is most frequently involved. The most common primary tumor sites to spread to this region originate in the kidney, breast, thyroid, and prostate, although any malignancy could potentially lead to a metastasis to the paranasal sinuses. The patient's prognosis is usually poor because of the fact that the sinonasal metastasis is usually associated with widespread disseminated disease. In the majority of patients, palliative therapy is the only possible treatment option. Nevertheless, whenever possible, surgical excision either alone or combined with radiotherapy may be useful for palliation of symptoms and, rarely, to achieve prolonged survival. This review considers the most interesting cases reported in the literature that presents metastases to the sinonasal cavities. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1847-1854, 2016.

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Section: Primary Tumor Sitesmentioning

confidence: 99%

Metastases to nasal cavity and paranasal sinuses

et al. 2016

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“…In some reports, patients presented with orbital metastasis many years after initial diagnosis with RCC [6,8,11]. In others, symptoms due to orbital metastasis were actually the only presenting signs of RCC [4,9-13].…”

Section: Discussionmentioning

confidence: 99%

Renal Cell Carcinoma Metastasis to an Uncommon Site: The Orbital Bone

Shahid

Kalayanamitra

Groff

et al. 2019

Cureus

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Renal cell carcinoma (RCC) represents 90% of all renal cancers. Patients may present with weight loss, hematuria, abdominal mass, abdominal pain, fever, and night sweats. The classic symptoms of flank pain, hematuria, and a palpable flank mass occur in less than 10% of patients and suggest advanced disease. However, most patients are typically asymptomatic and diagnosed incidentally. RCC metastasizes most commonly to the lung parenchyma, bone, liver, and brain and less commonly to the thyroid, pancreas, muscle, skin, and soft tissue. It is very rare for RCC to metastasize to the orbital bone. We present a case of a patient who presented with left cheek pain, tingling, and numbness and was ultimately found to have orbital metastasis of RCC.

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“…One of the first reports available in recent literature to describe a renal clear cell carcinoma metastatic to the paranasal sinuses has been published by Matsumoto and Yanagihara in 1982 [ 26 ]; afterwards several authors described case reports of RCC presenting as metastatic diseases in the paranasal sinuses. Available literature describes presentation of RCC metastasis as a solitary periorbital [ 27 ] and orbital mass [ 28 ], as a frontal sinus mass [ 29 ], as an ethmoid sinus mass [ 30 , 31 ], in the nasal cavity [ 32 , 33 ], in the maxillary [ 34 , 35 ], and sphenoid sinus [ 36 – 38 ]. In some cases, the extension of the metastasis to the skull base has been described [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma Presenting as a Paranasal Sinus Mass: The Importance of Differential Diagnosis

Ralli

Altissimi

Turchetta

et al. 2017

Case Reports in Otolaryngology

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Metastases in the paranasal sinuses are rare; renal cell carcinoma is the most common cancer that metastasizes to this region. We present the case of a patient with a 4-month history of a rapidly growing mass of the nasal pyramid following a nasal trauma, associated with spontaneous epistaxis and multiple episodes of hematuria. Cranial CT scan and MRI showed an ethmoid mass extending to the choanal region, the right orbit, and the right frontal sinus with an initial intracranial extension. Patient underwent surgery with a trans-sinusal frontal approach using a bicoronal incision combined with an anterior midfacial degloving; histological exam was compatible with a metastasis of clear cell renal cell carcinoma. Following histological findings, a total body CT scan showed a solitary 6 cm mass in the upper posterior pole of the left kidney identified as the primary tumor. Although rare, metastatic renal cell carcinoma should always be suspected in patients with nasal or paranasal masses, especially if associated with symptoms suggestive of a systemic involvement such as hematuria. A correct early-stage diagnosis of metastatic RCC can considerably improve survival rate in these patients; preoperative differential diagnosis with contrast-enhanced imaging is fundamental for the correct treatment and follow-up strategy.

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Metastatic Renal Cell Carcinoma to the Orbit and the Ethmoid Sinus

Cited by 12 publications

References 7 publications

Metastases to nasal cavity and paranasal sinuses

Metastases to nasal cavity and paranasal sinuses

Renal Cell Carcinoma Metastasis to an Uncommon Site: The Orbital Bone

Metastatic Renal Cell Carcinoma Presenting as a Paranasal Sinus Mass: The Importance of Differential Diagnosis

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