Metastatic Renal Cell Carcinoma Mimicking Pituitary Adenoma-Case Report-

Abstract

A 54-year-old man, with a past history of renal cell carcinoma, presented with bitemporal visual field defect, hyponatremia, and diabetes insipidus. Endocrinological examination revealed panhypopituitarism. Computed tomography and magnetic resonance imaging showed an intrasellar mass with suprasellar extension. The initial radiological impression was pituitary adenoma. The tumor was decompressed via the transsphenoidal route. Histological examination revealed metastatic renal cell carcinoma. The clinical characteristics of metastatic pituitary carcinoma appear to be panhypopituitarism, and neuroimaging findings of strong enhancement of the tumor and bony destruction without marked sellar enlargement.

Prostate Adenocarcinoma Metastasis in the Pituitary Gland

“…Metastatic adenocarcinomas in the pituitary gland mimicking pituitary adenoma have also been reported in rare cases of underlying primary renal cell carcinoma. 3 In this article, we demonstrate that similar differential diagnostic problems might also apply to pituitary metastases from other primary tumor sites such as the prostate gland. …”

Pituitary gland metastases from renal cell carcinoma: A case report and literature update

“…Symptomatic pituitary metastasis of renal cell carcinoma is very rare and only 25 cases have been described [1][2][3][4][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Only 7% of pituitary metastases are symptomatic [13,19,22].…”

“…Liu et al discovered that in many cases of pituitary metastasis there are a strong enhancement of the mass and a bone destruction without marked sellar enlargement [14]. T2-weighted MR images is frequently observed in these metastases [23].…”

Cystic Adrenal Hyperplasia - Diagnosis?

“…Reported cases include intracellular remote metastasis from an adenoid cystic carcinoma of parotid gland origin 16 and metastatic renal cell carcinoma presenting with a bitemporal visual field defect, hyponatremia and panhypopituitarism. 17 Finally, this condition can also be brought about by hypoadrenalocortism as a result of inappropriately tapered corticosteroids.…”