Prostate Adenocarcinoma Metastasis in the Pituitary Gland

Riemenschneider, Markus J.; Beseoglu, Kerim; Hänggi, Daniel; Reifenberger, Guido

doi:10.1001/archneurol.2009.146

Cited by 11 publications

(6 citation statements)

References 3 publications

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“…Metastasis to the bony orbit although rare, has been reported in the past [18] [19]. Rarely, PC has been reported to metastasize to the optic canal and the pituitary region [20] [21]. Most cases of soft tissue orbital metastasis secondary to PC involve the uveal tract.…”

Section: Discussionmentioning

confidence: 99%

Prostatic carcinoma presenting as unilateral proptosis - a rare case report

Kundargi¹,

Desai²,

Patil³

et al. 2015

Int J of Biomed & Adv Res

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Adenocarcinoma of prostate typically involves axial skeleton and has been infrequently reported in unusual sites like orbit. It is noteworthy that upto 1989, only 28 cases of occulo-orbital metastases of prostate cancer (PC) had been reported in the literature. PC is mostly known to metastasize to the bony skeleton. The lack of skeletal metastasis does not exclude the possibility of visceral/ distant metastasis, and serum PSA levels usually do not correlate with the extent of metastatic disease. Here in, we report a rare case of unilateral orbital metastasis from PC.

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Section: Discussionmentioning

confidence: 99%

Prostatic carcinoma presenting as unilateral proptosis - a rare case report

Kundargi¹,

Desai²,

Patil³

et al. 2015

Int J of Biomed & Adv Res

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“…Although cases of diplopia from cranial nerve palsies [6,7] or ocular rectus muscle invasion [8] from metastatic prostate cancer have been reported, these are relatively rare. Whilst it would have been tempting to make a presumptive diagnosis This is a rare case of a concomitant atypical meningioma, possibly further stimulated by the use of ADT for prostate cancer treatment.…”

Section: Discussionmentioning

confidence: 99%

Prostate Cancer - Double Vision but Solitary Lesion

Lim¹,

Perchyonok²,

Fitt³

et al. 2014

JOURNAL OF CASE REPORTS AND STUDIES

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A 53 year old man with a background of castrate-sensitive prostate cancer on intermittent androgen deprivation therapy (ADT) presented with right sixth nerve palsy secondary to a solitary right petroclival lesion involving adjacent dura and bone. The clinical and imaging characteristics of the lesion were consistent with a number of differential diagnoses (including metastatic prostate cancer, meningioma and chondrosarcoma). The patient initially declined biopsy and ADT was recommenced but the lesion continued to enlarge despite an excellent biochemical response. A subsequent biopsy of the petroclival mass demonstrated a WHO grade I meningioma and the patient proceeded to have definitive stereotactic radiotherapy. This case illustrates an unusual solitary skull base lesion in a man with prostate cancer. Whilst bony metastases, usually multiple, in the skeleton are common, solitary skull or brain lesions should be investigated as alternate diagnoses are likely in such circumstance.

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“…Metastatic involvement of the pituitary and infundibular stalk is a rare occurrence (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). Primary tumor histologic subtypes which have been documented to spread to the pituitary include lung cancer (NSCLC and SCLC), breast cancer, prostate cancer, renal cell carcinoma, and melanoma (among others), with lung cancer and breast cancer being the most frequently reported [4,5,7,13].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical presentations range from isolated diabetes insipidus, to visual loss or diplopia, to full-blown panhypopituitarism [3][4][5][6][7][8][9][10][11]13]. These presenting toxicities have been shown to resolve completely or partially in some but not all cases with acute surgical decompression (via trans-sphenoidal resection), radiation therapy, chemotherapy, and anti-hormonal therapy in the case of metastatic prostatic adenocarcinoma [1,3,7,11]. Differentiation of a pituitary metastasis from a primary pituitary neoplasm (adenoma or carcinoma) can be difficult [4][5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…Involvement of the pituitary gland by metastatic disease is extremely rare, with most of the existing data based on individual case reports and literature reviews [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]. We recently treated a patient with a prior history of colonic adenocarcinoma who presented postoperatively after transsphenoidal resection of an isolated metastatic lesion involving the sellar floor.…”

Section: Introductionmentioning

confidence: 99%

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Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

et al. 2010

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We present a case report of a patient recently treated at our institution for an isolated non-small cell lung cancer metastatic lesion to the sella, report the lack of involvement of the pituitary gland in a large single-institution series of treated intracranial parenchymal metastases, and review the pertinent literature. We reviewed cranial imaging studies (CT and MRI) for 935 metastases in 155 patients treated at our institution over the previous 3 years for intracranial metastatic disease. Special attention was paid to the skull base to document the presence of any metastatic disease involving the pituitary gland, infundibular stalk, sella turcica (including anterior and posterior clinoids), or diaphragm sellae. We found no other involvement of the pituitary gland or other sellar structures by metastatic disease in this series. Intracranial metastatic disease rarely involves the pituitary gland and infundibular stalk parenchyma, suggesting that this structure may be safely omitted from the treatment field during WBRT and prophylactic cranial irradiation (PCI). This treatment approach should reduce the late sequelae of treatment to this critical organ.

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Prostate Adenocarcinoma Metastasis in the Pituitary Gland

Cited by 11 publications

References 3 publications

Prostatic carcinoma presenting as unilateral proptosis - a rare case report

Prostatic carcinoma presenting as unilateral proptosis - a rare case report

Prostate Cancer - Double Vision but Solitary Lesion

Intracranial metastatic disease rarely involves the pituitary: retrospective analysis of 935 metastases in 155 patients and review of the literature

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