Metastatic Prostatic Adenocarcinoma Mimicking Inflammatory Breast Carcinoma: A Case Report

Njiaju, Uchenna O.; Truica, Cristina I.

doi:10.3816/cbc.2010.n.013

Cited by 10 publications

(12 citation statements)

References 11 publications

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“…174 Clinically, cutaneous metastases from prostatic carcinoma present as firm, violaceous, multiple nodules located on the abdominal wall, suprapubic area, anterior aspect of the thighs, 4 and near the umbilicus as another manifestation of Sister Mary Joseph nodule. 72 However, other clinical presentations have been reported, such as morphea-like lesions on the chest, 39 skin lesion resembling a vascular proliferation, 203 large plaques mimicking inflammatory breast carcinoma 204 (Fig. 17), telangiectatic cutaneous lesions, 205 a large tricholemmal cyst located on the scalp, 206 a lipoma on the face, 207 and multiple lesions with zosteriform pattern.…”

Section: Prostatic Carcinomasmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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Section: Prostatic Carcinomasmentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

218

104

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“…A review of the literature reveals 35 English language case reports in which the patient's prostate carcinoma metastasized to the skin. In some cases, the metastasis was local, involving penile or scrotal tissue, whereas in others the site of a distant metastasis was detected as a rash or nodules on the face .…”

mentioning

confidence: 99%

Cutaneous metastasis of prostate cancer: a case report and review of the literature with bioinformatics analysis of multiple healthcare delivery networks

2014

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Distant cutaneous metastases of prostate carcinomas are extremely rare, despite its high incidence and prevalence. Most cases are either a result of local extension, such as into seminal vesicles or distant metastases to bone. Few cases of true cutaneous metastatic prostate carcinoma exist in the literature. Clinically, cutaneous prostate carcinoma has been reported to mimic many other conditions, such as cellulitis, sebaceous cysts, zosteriform lesions, telangectasias and more, resulting in poor recognition. We report a case of distant cutaneous metastasis of prostate carcinoma and recent review of the literature with an analysis of de-identified patient records from multiple healthcare delivery networks. A diagnosis of metastatic prostate carcinoma may have been easily overlooked given the location and nature of the rash. Reviewing case reports and using aggregated electronic health records (EHRs), we find that fewer than 0.1% of all prostate carcinomas result in cutaneous metastases, compared with much higher rates in other types of cancers. Coupled with the low frequency of metastases to skin, careful consideration must be taken when evaluating a rash in a patient with a prior history of cancer. A complete clinical history and strong suspicion would be required to make a diagnosis of cutaneous metastases of the prostate.

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“…Clinical inflammatory presentation due to the involvement of superficial dermal lymphatic vessels and including tenderness, erythema, pain, and induration has never been reported so far for primary squamous cell cervical cancer, but has been reported for other primary cancers metastatic to the breast, e.g. ovarian cancer [15, 16], prostate cancer [17], cervical adenocarcinoma [9, 18], adenosquamous carcinoma [10], and lung adenocarcinoma [18]. Diffuse skin invasion and cutaneous permeation nodules have been reported with breast metastasis from melanoma [19].…”

Section: Discussionmentioning

confidence: 99%

Breast Metastasis of a Squamous Cell Carcinoma of the Uterine Cervix Mimicking Inflammatory Breast Cancer

Sabatier¹,

Roussin²,

Rivière

et al. 2012

Case Rep Oncol

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Breast metastases from distant carcinoma are infrequent, and cervix carcinoma is rarely the primary lesion. We describe the first case of a cervical squamous cell carcinoma with breast metastasis mimicking an inflammatory breast cancer in a 74-year-old woman. Seventeen months after the treatment of a primary tumor, the patient developed breast lesions looking like an inflammatory breast tumor. After a 1-year delay due to the patient’s refusal, pathological examination and immunohistochemistry confirmed the diagnosis of breast metastasis from a poorly differentiated squamous cell carcinoma. The volume of the breast was huge, associated with axillary lymphadenopathies and multiple lung metastases. Despite platinum-based chemotherapy, the disease progressed and the patient died rapidly, 3 months after the first chemotherapy cycle and 15 months after the first mammary symptoms. We review the literature concerning breast metastases from gynecologic cancers and, particularly, from cervical squamous cell carcinoma. Differential diagnosis of such lesions may be problematic but is essential to avoid unnecessary mutilating surgery and to institute the appropriate systemic therapy. The prognosis is poor.

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Metastatic Prostatic Adenocarcinoma Mimicking Inflammatory Breast Carcinoma: A Case Report

Cited by 10 publications

References 11 publications

Cutaneous Metastases From Internal Malignancies

Cutaneous Metastases From Internal Malignancies

Cutaneous metastasis of prostate cancer: a case report and review of the literature with bioinformatics analysis of multiple healthcare delivery networks

Breast Metastasis of a Squamous Cell Carcinoma of the Uterine Cervix Mimicking Inflammatory Breast Cancer

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