Cutaneous metastasis of prostate cancer: a case report and review of the literature with bioinformatics analysis of multiple healthcare delivery networks

Abstract

Distant cutaneous metastases of prostate carcinomas are extremely rare, despite its high incidence and prevalence. Most cases are either a result of local extension, such as into seminal vesicles or distant metastases to bone. Few cases of true cutaneous metastatic prostate carcinoma exist in the literature. Clinically, cutaneous prostate carcinoma has been reported to mimic many other conditions, such as cellulitis, sebaceous cysts, zosteriform lesions, telangectasias and more, resulting in poor recognition. We report a case of distant cutaneous metastasis of prostate carcinoma and recent review of the literature with an analysis of de-identified patient records from multiple healthcare delivery networks. A diagnosis of metastatic prostate carcinoma may have been easily overlooked given the location and nature of the rash. Reviewing case reports and using aggregated electronic health records (EHRs), we find that fewer than 0.1% of all prostate carcinomas result in cutaneous metastases, compared with much higher rates in other types of cancers. Coupled with the low frequency of metastases to skin, careful consideration must be taken when evaluating a rash in a patient with a prior history of cancer. A complete clinical history and strong suspicion would be required to make a diagnosis of cutaneous metastases of the prostate.

Cutaneous metastasis of prostate carcinoma treated with electron radiotherapy

“…In addition, there exists the possibility that a skin lesion may represent an undiagnosed metastasis. 5 The number of prostate carcinoma has been increasing rapidly in recent years, and the development of cutaneous metastasis, as observed in the present case, appears to be increasing at a constant rate.…”

Cutaneous metastases from prostate cancer revealing neuroendocrine differentiation

“…Despite the high frequency of prostate adenocarcinoma, cutaneous metastases are estimated in less than 0.1% of patients . In addition, skin metastasis with NE differentiation is an extremely rare phenomenon.…”

Metástasis cutánea de adenocarcinoma de próstata: una presentación inusual. Reporte de un caso y revisión de literatura

“…El hallazgo histopatológico es similar al de otras MC descritas, siendo positiva en inmunohistoquímica para el antígeno prostático específico (PSA); sin embargo, cuando la neoplasia es indiferenciada se puede perder la positividad para PSA (13) .…”