Metastatic Pleural Effusion: A Rare Presentation of Salivary Gland Adenoid Cystic Carcinoma

Mitra, Subodh; Kundu, S. S.; Pattari, Sanjib; Ghosal, Anirban

doi:10.5005/ijcdas-53-2-107

Cited by 5 publications

(10 citation statements)

References 13 publications

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“…ACC is characterised by a protracted clinical course with multiple local recurrences and late metastatic spread. 2,3 Disease-free intervals have been reported to range between 1 month and 19 years, with a median interval of 36 months. 4 Distant haematogenous metastasis is more frequent than regional lymph node metastasis, and most commonly involves the lung, followed by liver and bone.…”

Section: Discussionmentioning

confidence: 99%

“…4 Distant haematogenous metastasis is more frequent than regional lymph node metastasis, and most commonly involves the lung, followed by liver and bone. 1,2 Although ACC has a good short-term prognosis, its long-term prognosis is poor, with estimated survival rates of 68%, 52% and 28% at 5, 10 and 20 years, respectively. 5 Significant predictors of survival include tumour stage, nodal status, histological grade and patient age.…”

Section: Discussionmentioning

confidence: 99%

“…5 The treatment of choice of ACC is radical excision and post-operative radiotherapy. 1,2 Radiotherapy as a monotherapy has a high rate of local recurrence but may provide useful palliative therapy in non-resectable cases. 1,2 The role of chemotherapy and other systemic agents in the treatment of ACC has not yet been clearly established.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Radiotherapy as a monotherapy has a high rate of local recurrence but may provide useful palliative therapy in non-resectable cases. 1,2 The role of chemotherapy and other systemic agents in the treatment of ACC has not yet been clearly established. 1,2 Histologically, ACC consists of a dual population of myoepithelial cells and ductal cells.…”

Section: Discussionmentioning

confidence: 99%

“…1 Other sites of occurrence include lung, breast, skin, cervix and prostate. [1][2][3] Its most common site of distant metastasis is the lung, followed by liver and bone. 1 We report a rare case of ACC of the floor of mouth metastasising to the lung, pleura and pericardium.…”

Section: Introductionmentioning

confidence: 99%

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Malignant pleural effusion and pericardial effusion, an unusual presentation of metastatic adenoid cystic carcinoma of the floor of mouth: A case report with cyto‐histopathological correlation

Lin,

Nandakumar

2023

Diagnostic Cytopathology

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Adenoid cystic carcinoma (ACC) is an uncommon tumour that represents 5%–10% of salivary gland tumours and 1% of all head and neck malignancies. It is characterised by a protracted clinical course with late metastasis and poor long‐term prognosis. We report the case of a 38‐year‐old woman presenting with pulmonary and pleural metastases, on the background of ACC of the floor of mouth, which had been treated 4 years ago with surgical excision and radiotherapy. Cytological evaluation of the pleural effusion showed exfoliated ACC tumour cells. Despite palliative chemotherapy, the patient developed disease progression including metastatic spread to the pericardium, and died of disease within a year. This case illustrates an unusual presentation of ACC and highlights the importance of considering this entity when encountering a basaloid neoplasm in extra‐salivary locations.

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Section: Discussionmentioning

confidence: 99%