Metastatic patterns in squamous cell cancer of the head and neck

Kotwall, Cyrus A.; Sako, Kumao; Razack, Mohamed S.; Rao, Uma; Bakamjian, Vahram; Shedd, Donald P.

doi:10.1016/0002-9610(89)90020-2

Cited by 294 publications

(171 citation statements)

References 8 publications

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“…5 Less frequent metastases have also been described in long bones (femur, tibia, and ribs). 3 Retrospective studies of human head and neck SCC demonstrated that the most common site of distant metastasis is the lung, 6,10,11 and bone is the second 10 or fourth 6 most common site.…”

Section: Metastatic Oral Squamous Cell Carcinoma In a Montagu's Harrimentioning

confidence: 99%

Metastatic Oral Squamous Cell Carcinoma in a Montagu's Harrier (Circus Pigargus)

et al. 1999

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Section: Metastatic Oral Squamous Cell Carcinoma In a Montagu's Harrimentioning

confidence: 99%

Metastatic Oral Squamous Cell Carcinoma in a Montagu's Harrier (Circus Pigargus)

et al. 1999

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“…Tobacco and alcohol are major contributors to the development of this type of cancer. Although lymph node metastases are much more common in SCCHN patients (f60%), up to 20% to 25% of patients with SCCHN develop distant metastatic disease where the main sites of metastases are the lungs, liver, and bone (1). SCCHN patients without nodal and distant metastases have a more favorable prognosis than their counterparts.…”

Section: Introductionmentioning

confidence: 99%

CXC Chemokine Receptor-4 Antagonist Blocks Both Growth of Primary Tumor and Metastasis of Head and Neck Cancer in Xenograft Mouse Models

et al. 2007

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Squamous cell carcinoma of the head and neck (SCCHN) metastasizes to the lymph nodes and lungs. We have generated previously an orthotopic mouse model for head and neck metastasis and did in vivo selection of SCCHN cells through four rounds of serial metastases. A subpopulation of 686LN cells with high metastatic potential (686LN-Ms) was isolated. When the highly metastatic cells were compared with their low metastatic parental cells (686LN-Ps), we found that CXC chemokine receptor-4 (CXCR4) mRNA levels were significantly higher in the 686LN-Ms cells than the 686LN-Ps cells. Interestingly, the metastatic subclones had lost epithelial morphology and acquired mesenchymal features, which were maintained during cell expansion in vitro. This was featured by decreased E-cadherin and involucrin and increased vimentin and integrin B 1 . These results imply that CXCR4 and epithelial-mesenchymal transition markers can be potential biomarkers to identify the subpopulation of cells with high metastatic potential. Using the orthotopic SCCHN animal model, we showed that anti-CXCR4 treatment suppressed primary tumor growth by inhibiting tumor angiogenesis and prevented lung metastasis. Because the reduction of metastasis seen in the treated group could have resulted from 2-fold reduction in primary tumor size compared with that in the control group, we examined the effects of the CXCR4 antagonist in an experimental metastatic animal model in which 686LN-Ms cells were i.v. injected. 686LN-Ms cells failed to metastasize in the CXCR4 antagonist-treated group, whereas they metastasized to the lungs in the control group. Our data indicate that CXCR4 is an important target to inhibit tumor progression in SCCHN. [Cancer Res 2007;67(15):7518-24]

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“…The incidence of distant metastasis is hypopharynx 60%, base of tongue 53%, and anterior tongue cancer 50%. [8] Distant metastasis to bones from buccal mucosa is extremely rare and we could fi nd only one report. [9] In contrast, in the last 5 years, our center diagnosed 4 cases of squamous cell carcinoma of the buccal mucosa which had metastasized to bones.…”

Section: Discussionmentioning

confidence: 87%

Incidence of bone metastasis in squamous cell carcinoma of the buccal mucosa

Bhandari¹

2015

J Cancer Metastasis Treat

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Aim: This retrospective study was performed to show the incidence of bone metastasis from carcinoma of the buccal mucosa. Head and neck cancer is a leading health problem in India due to an increased incidence of tobacco use and poor oral hygiene. Squamous cell carcinoma of the buccal mucosa is common and roughly 2.5% of all malignancies that present to our center. Moreover, most patients present at late stages (III/IV) and consequently, survival rates are low. Bone metastasis in advanced cases of such carcinomas is rarely reported worldwide but is more prominent in parts of India. Methods: Here, we present a series of patients diagnosed with buccal mucosa carcinomas within the past 5 years that also demonstrated bone metastases. Results: These patients were young, with a history of tobacco chewing with locally advanced disease and bone metastases that developed within one year of diagnosis. Flat bones and vertebrae were mainly involved and the survival was short after diagnosis of metastasis despite treatment with local radiotherapy and chemotherapy. The cause of such frequent metastases cannot be proved but subclinical seeding of malignant cells before the eradication of the primary tumor is probable contributory with advanced local and nodal disease with high grade tumor. Conclusion: A pretreatment bone scan should be performed in locoregionally advanced buccal mucosa carcinomas at the time of diagnosis to defi ne the treatment plan.

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Metastatic patterns in squamous cell cancer of the head and neck

Cited by 294 publications

References 8 publications

Metastatic Oral Squamous Cell Carcinoma in a Montagu's Harrier (Circus Pigargus)

Metastatic Oral Squamous Cell Carcinoma in a Montagu's Harrier (Circus Pigargus)

CXC Chemokine Receptor-4 Antagonist Blocks Both Growth of Primary Tumor and Metastasis of Head and Neck Cancer in Xenograft Mouse Models

Incidence of bone metastasis in squamous cell carcinoma of the buccal mucosa

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