Metastatic neuroblastoma mimicking an infantile hemangioma

Fernández, Cristina Gómez; Feito-Rodríguez, M.; Bandera, Ana Rodríguez; Quintana‐Castanedo, Lucía; Bravo, Elena; Laguna, Raúl de Lucas

doi:10.1111/pde.14421

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…In addition, Avola et al ( 14 ) reported a SSTM in the outer upper quadrant of the breast, in which the ultrasound showed an internal mottled calcification. The other 3 cases ( 15 - 17 ) showed only a hypoechoic mass on US. At first diagnosis, they were misdiagnosed as neurofibroma, lymphatic malformation, and hemangioma.…”

Section: Discussionmentioning

confidence: 99%

Neuroblastoma with superficial soft tissue mass as the first symptom: case reports with atypical ultrasonic image and literature review

Hu,

Xia,

Yuan

et al. 2023

Braz J Med Biol Res

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Neuroblastoma is one of the most common tumors in children. Cases where an isolated soft-tissue metastasis mass is the initial symptom are rare, with only four such cases reported to date. We describe the imaging findings of ten cases of neuroblastoma patients in our hospital with superficial soft tissue mass (SSTM) as the primary symptom. The main ultrasound finding of SSTM was hypoechoic masses or scattered speck-like hyperechoic masses. However, when this type of SSTM is caused by soft tissue metastasis, the location is often atypical, and ultrasound findings are difficult to distinguish from other benign diseases. Therefore, this research should remind clinicians to recognize atypical presentations of this common childhood malignant tumor. Radiologists should also consider the possibility of neuroblastoma when finding this type of SSTM with atypical ultrasound features.

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Section: Discussionmentioning

confidence: 99%

Neuroblastoma with superficial soft tissue mass as the first symptom: case reports with atypical ultrasonic image and literature review

Hu,

Xia,

Yuan

et al. 2023

Braz J Med Biol Res

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“…Metastatic lesions may also present in the periorbital area (Figure 2). 9 A clinical tool for diagnosis may be performed by looking for a distinctive central blanching and erythematous halo that develops 2 to 3 min after stroking the lesion 3 . “Raccoon eyes” (periorbital ecchymosis) from periorbital metastasis, and heterochromia iridis, may also provide clues, though are often absent 3 .…”

Section: The Nonspecific Lump or Bump: Possible Diagnosesmentioning

confidence: 99%

“…Metastatic neuroblastoma presenting as a skin‐colored tumor of the left lower eyelid. Borrowed with permission from Chiloeches Fernández et al (2021) 9 …”

Section: The Nonspecific Lump or Bump: Possible Diagnosesmentioning

confidence: 99%

Lumps and bumps: What not to miss

Levin

Kinariwalla

Behr

et al. 2022

Pediatric Dermatology

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The evaluation of pediatric patients with subcutaneous nodules remains a diagnostic challenge. Pediatric dermatologists are regularly confronted with patients who have a nonspecific nodule. Though most masses that require evaluation are ultimately benign, the possibility of a more aggressive process, including borderline or malignant neoplasms, underscores the pivotal role of the pediatric dermatologist in recognizing these lesions. The aim of this review is to provide an overview of lumps and bumps that are important to recognize to prevent delay in diagnosis or treatment of a serious underlying condition. Clinical clues that may lead the pediatric dermatologist to have a higher index of suspicion for more aggressive lesions are reviewed. Suggestions for evaluation and workup, as well as tips for the difficult to discern lesion, are proposed.

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“…For example, KHE typically responds to sirolimus35 and not to beta blocker therapy, RICH does not require therapy other than supportive care, and IH typically responds to beta blocker therapy. The differential diagnosis should also include other vascular tumors including benign, borderline, and malignant tumors, such as neuroblastoma and angiosarcoma 36–39…”

Section: Differential Diagnosismentioning

confidence: 99%

“…The differential diagnosis should also include other vascular tumors including benign, borderline, and malignant tumors, such as neuroblastoma and angiosarcoma. [36][37][38][39]…”

Section: Differential Diagnosismentioning

confidence: 99%

Infantile Hemangioma: A Current Review

Pahl

McLean

2021

Journal of Pediatric Hematology/Oncology

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Infantile hemangiomas (IHs) are common vascular lesions which are benign but can cause significant functional and cosmetic morbidity. Since the fortuitous discovery of propranolol being effective to treat IH over a decade ago, the therapy and prognosis for children with IH have improved dramatically. Oral propranolol (as well as other oral beta-blockers and topical timolol) are safe and effective treatments, and have now supplanted other therapies. Making the correct diagnosis is crucial, because other vascular lesions can mimic IH. In addition, IH can be the first manifestation of an underlying syndrome. For IH requiring treatment, initiating treatment early is key to optimizing success. Therefore, early recognition and referral, if necessary, are important. Continued research on IH, both basic science and clinical, should result in continued advances.

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Metastatic neuroblastoma mimicking an infantile hemangioma

Abstract: Neuroblastoma is the most common solid tumor malignancy in the first year of life. We present a rare case of a 5-month-old girl with an infraorbital tumor that simulated an infantile hemangioma clinically but was ultimately diagnosed as metastatic neuroblastoma.

Cited by 7 publications

References 5 publications

Neuroblastoma with superficial soft tissue mass as the first symptom: case reports with atypical ultrasonic image and literature review

Neuroblastoma with superficial soft tissue mass as the first symptom: case reports with atypical ultrasonic image and literature review

Lumps and bumps: What not to miss

Infantile Hemangioma: A Current Review

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