Metastatic multifocal melanoma of multiple organ systems: A case report

Maksimaityte, Vaidota; Reivytyte, Rosita; Milaknyte, Gabriele; Mickys, Ugnius; Razanskiene, Gintare; Stundys, Domantas; Kazėnaitė, Edita; Valantinas, Jonas; Stundiene, Ieva

doi:10.12998/wjcc.v10.i28.10136

Cited by 6 publications

(2 citation statements)

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“…Another great advantage of immunohistochemical analysis is its considerably lower costs compared to molecular analysis while the results are similar, with a study reporting a sensitivity of 80.8% and specificity of 100% for immunohistochemistry [103]. In spite of these promising results, at present BRAF V600E immunohistochemical results should be confirmed by PCR analysis, as concordance between the two methods varies between 71.4 and 97% [101]. In the future, immunohistochemical methods for BRAF detection may significantly improve, providing increased diagnostic accuracy at lower costs.…”

Section: Diagnostic and Prognostic Immunohistochemical Markers In CMmentioning

confidence: 83%

“…In addition to these markers, BRAF V600E immunohistochemical analysis is increasingly performed for primary cutaneous melanomas and metastatic lesions [100,101]. This method is particularly useful for diagnosing dedifferentiated melanomas that lack expression of conventional melanocytic markers and may aberrantly express other markers [102].…”

Section: Diagnostic and Prognostic Immunohistochemical Markers In CMmentioning

confidence: 99%

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Cutaneous Melanoma: A Review of Multifactorial Pathogenesis, Immunohistochemistry, and Emerging Biomarkers for Early Detection and Management

Gosman,

Țăpoi,

Costache

2023

IJMS

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Cutaneous melanoma (CM) is an increasingly significant public health concern. Due to alarming mortality rates and escalating incidence, it is crucial to understand its etiology and identify emerging biomarkers for improved diagnosis and treatment strategies. This review aims to provide a comprehensive overview of the multifactorial etiology of CM, underscore the importance of early detection, discuss the molecular mechanisms behind melanoma development and progression, and shed light on the role of the potential biomarkers in diagnosis and treatment. The pathogenesis of CM involves a complex interplay of genetic predispositions and environmental exposures, ultraviolet radiation exposure being the predominant environmental risk factor. The emergence of new biomarkers, such as novel immunohistochemical markers, gene mutation analysis, microRNA, and exosome protein expressions, holds promise for improved early detection, and prognostic and personalized therapeutic strategies.

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Section: Diagnostic and Prognostic Immunohistochemical Markers In CMmentioning

confidence: 83%