Inhibition of melanoma cell migration and invasion by natural coumarin auraptene through regulating EMT markers and reducing MMP-2 and MMP-9 activity

Hosseini, Fatemehsadat; Ahmadi, Abdolreza; Hassanzade, Halimeh; Gharedaghi, Shahin; Rassouli, Fatemeh B.; Jamialahmadi, Khadijeh

doi:10.1016/j.ejphar.2024.176517

European Journal of Pharmacology

2024

DOI: 10.1016/j.ejphar.2024.176517

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Inhibition of melanoma cell migration and invasion by natural coumarin auraptene through regulating EMT markers and reducing MMP-2 and MMP-9 activity

Fatemehsadat Hosseini,

Abdolreza Ahmadi,

Halimeh Hassanzade

et al.

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2024

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Cited by 3 publications

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Unveiling esophageal cancer treatment mechanisms: network pharmacology and molecular docking of Physcion

Hu,

Guo,

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Unveiling esophageal cancer treatment mechanisms: network pharmacology and molecular docking of Physcion

Hu,

Guo,

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Zerumbone Induces Apoptosis and Inhibits Migration of A2058 Melanoma stem-like Cells by Producing Reactive Oxygen Species, Causing G2/M Cell Cycle Arrest, and Controlling the Expression of Genes Linked to Metastasis

Ostadi,

Vahedi,

Abbasinezhad-moud

et al. 2024

Ind J Clin Biochem

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Natural Product Auraptene Targets SLC7A11 for Degradation and Induces Hepatocellular Carcinoma Ferroptosis

Li,

Chen

et al. 2024

Antioxidants

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The natural product auraptene can influence tumor cell proliferation and invasion, but its effect on hepatocellular carcinoma (HCC) cells is unknown. Here, we report that auraptene can exert anti-tumor effects in HCC cells via inhibition of cell proliferation and ferroptosis induction. Auraptene treatment induces total ROS and lipid ROS production in HCC cells to initiate ferroptosis. The cell death or cell growth inhibition of HCC cells induced by auraptene can be eliminated by the ROS scavenger NAC or GSH and ferroptosis inhibitor ferrostatin-1 or Deferoxamine Mesylate (DFO). Mechanistically, the key ferroptosis defense protein SLC7A11 is targeted for ubiquitin–proteasomal degradation by auraptene, resulting in ferroptosis of HCC cells. Importantly, low doses of auraptene can sensitize HCC cells to ferroptosis induced by RSL3 and cystine deprivation. These findings demonstrate a critical mechanism by which auraptene exhibits anti-HCC effects via ferroptosis induction and provides a possible therapeutic strategy for HCC by using auraptene or in combination with other ferroptosis inducers.

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Inhibition of melanoma cell migration and invasion by natural coumarin auraptene through regulating EMT markers and reducing MMP-2 and MMP-9 activity

Cited by 3 publications

References 48 publications

Unveiling esophageal cancer treatment mechanisms: network pharmacology and molecular docking of Physcion

Unveiling esophageal cancer treatment mechanisms: network pharmacology and molecular docking of Physcion

Zerumbone Induces Apoptosis and Inhibits Migration of A2058 Melanoma stem-like Cells by Producing Reactive Oxygen Species, Causing G2/M Cell Cycle Arrest, and Controlling the Expression of Genes Linked to Metastasis

Natural Product Auraptene Targets SLC7A11 for Degradation and Induces Hepatocellular Carcinoma Ferroptosis

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