Metastatic leiomyosarcoma in the oral cavity: Case report with protein expression profiles

Kim, Soung Min; Myoung, Hoon; Choung, Pill Hoon; Kim, Myung Jin; Lee, Suk Keun; Lee, Jong Ho

doi:10.1016/j.jcms.2009.06.010

Cited by 34 publications

(29 citation statements)

References 7 publications

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“…Thus, before considering it as the primary site, a complete medical evaluation and search for LMS elsewhere should be carried out to exclude metastatic disease [9,10]. Metastatic tumors are rare in the mouth; even so, we could find only eight well-documented cases of oral metastatic LMS in the English language literature [4,6,7,9,10,14]. Although oral metastatic deposits occur more commonly in the jaws [24,25], only three of these cases affected these sites-one occurred in the mandible mimicking periapical disease [6], one developed in maxilla with extension into the oral cavity [14], and the other one involved both mandible and maxilla [10].…”

Section: Discussionmentioning

confidence: 99%

“…Metastatic tumors are rare in the mouth; even so, we could find only eight well-documented cases of oral metastatic LMS in the English language literature [4,6,7,9,10,14]. Although oral metastatic deposits occur more commonly in the jaws [24,25], only three of these cases affected these sites-one occurred in the mandible mimicking periapical disease [6], one developed in maxilla with extension into the oral cavity [14], and the other one involved both mandible and maxilla [10]. Two other cases involved the palate [7,9], and one of each other involved the lip [9], the retromolar area [9], and the tongue [4].…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of LMS in the oral cavity is extremely uncommon due to the scarcity of smooth muscle tissue in the mouth [3]. Oral LMS may occur as primary tumors, metastasis, or radiation-associated tumors [4][5][6][7][8][9][10][11][12][13][14], the two latter being exceedingly rare. The present report describes two cases of oral LMS: one developing in a previously irradiated area and the other developing as a metastasis from an abdominal tumor.…”

Section: Introductionmentioning

confidence: 99%

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Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

Azevedo

Pires

Gouvêa

et al. 2011

Oral Maxillofac Surg

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Post-radiotherapy sarcomas of the oral cavity and oral metastasis from soft tissue sarcomas are very uncommon, but based on patient's clinical history, they should be considered by oral health care providers in order to allow an early diagnosis and proper and timely management. Finally, to the best of our knowledge, this seems to be the first reported case of tongue leiomyosarcoma arising in a previously irradiated field.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

Azevedo

Pires

Gouvêa

et al. 2011

Oral Maxillofac Surg

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“…vWF abnormality has been reported in both hematologic malignancies and nonhematologic malignancies, including chronic lymphocytic leukemia [78], acute lymphoblastic leukemia [79], colorectal carcinoma [80], leiomyosarcoma [81], breast cancer [82] and prostate cancer [83]. In an experimental metastasis mouse model, vWF was observed to inhibit tumor metastasis [45].…”

Section: The Significance Of Vwf In Diseasesmentioning

confidence: 99%

von Willebrand Factor: More Than a Regulator of Hemostasis and Thrombosis

Luo

Yang

et al. 2012

Acta Haematol

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von Willebrand factor (vWF) was first identified as an adhesive glycoprotein involved in hemostasis by Zimmermann in 1971. Since then, vWF has been shown to play a vital role in platelet adhesion, platelet binding to collagen and factor VIII protection. Recent studies have implicated vWF as a regulator of angiogenesis, smooth muscle cell proliferation, tumor cell metastasis and crosstalk in the immune system. In this review, we will discuss the aspects of vWF structure that facilitate its biological effects and speculate on its newly discovered and hypothesized roles in the pathogenesis of several diseases.

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“…Clinical data were correlated with tumor grade, which was assessed using the National Cancer Institute system. 21 Owing to the retrospective nature of the study, it was granted a written exemption of the institutional review board standards of individual institutions by the universities of Regensburg and L€ ubeck. In addition, all patients signed an informed written consent agreement allowing the use of follow-up data and histologic specimens for research purposes.…”

Section: Methodsmentioning

confidence: 99%

Primary and Secondary Leiomyosarcoma of the Oral and Perioral Region—Clinicopathological and Immunohistochemical Analysis of a Rare Entity With a Review of the Literature

Schütz

Smeets

Driemel

et al. 2013

Journal of Oral and Maxillofacial Surgery

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Purpose: Leiomyosarcoma (LMS) rarely occurs in the head and neck region. These tumors present with a wide range of clinical features, so the diagnosis is predicated on conventional microscopic findings coupled with immunohistochemical analysis.Patients and Methods: Clinical and histologic data of 7 patients with LMS of the head and neck were recorded retrospectively. In addition to routine immunohistochemistry, staining for cell cycle regulator proteins p16 and p21 was performed.Results: Five LMSs (4 intraoral, 1 dermal cheek) occurred primarily in the oral and perioral region. Two LMSs (parietal and sinonasal) were diagnosed as metastases originating from the uterus and pelvis. Treatment of the primary LMSs consisted of radical tumor resection with clear margins. Distant metastases from LMSs were irradiated or excised as palliative treatment. Three of 5 patients (60%) with primarily excised LMS developed recurrence after an average of 7 months, with lung metastases occurring after 17 months. In 1 patient, cervical lymph node metastases were detected after 10 months. Of all patients, 5 died after an average survival period of 2.4 years. The mean survival period of the 5 patients with primary LMS of the head and neck was 3.3 years. All tumors were positive for vimentin and a-smooth muscle actin, with 57% of tumors showing positive nuclear expression of p16 and 71% of p21. Lack of p16 nuclear expression was associated with a shorter mean survival time (1.3 vs 4.3 yr for p16 positivity).Conclusion: Lung and cervical lymph node metastases often occur in LMS of the head and neck. Presurgical staging, including gynecologic examination, whole-body computed tomography, and sometimes positron-emission or computed tomography, to rule out LMS metastasis is mandatory. Surgical resection of the tumor should be given top priority. Lack of p16 reactivity may have a prognostic value for LMS because it was related to a trend toward poorer survival. Ó

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Metastatic leiomyosarcoma in the oral cavity: Case report with protein expression profiles

Cited by 34 publications

References 7 publications

Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

Leiomyosarcomas of the oral cavity: report of a radiation-associated and a metastatic case

von Willebrand Factor: More Than a Regulator of Hemostasis and Thrombosis

Primary and Secondary Leiomyosarcoma of the Oral and Perioral Region—Clinicopathological and Immunohistochemical Analysis of a Rare Entity With a Review of the Literature

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