Metastatic intraocular chondrosarcoma in a dog

Rodrigues, Emilio Fernandes; Ribeiro, Alexandre Pinto; Perlmann, Eduardo; Brooks, Dennis; Laus, José Luiz

doi:10.1111/j.1463-5224.2009.00703.x

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…`Chondrosarcomas commonly affect the flat bones but approximately 1% of chondrosarcomas develop in extraskeletal locations such as the spleen, kidney, liver, mammary gland, intestine, omentum, lung, mitral leaflet, atrium, aorta, pulmonary artery, urethra, and eye 3–12 . Extraskeletal chondrosarcomas can arise from areas where cartilage is not normally found, and are suspected to originate from cartilaginous differentiation of primitive mesenchymal cells 7–9,13 …”

Section: Discussionmentioning

confidence: 99%

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Imaging Diagnosis-Spinal Cord Chondrosarcoma Associated With Spirocercosis in a Dog

Lindsay

Kirberger

Williams

2010

Veterinary Radiology &Amp; Ultrasound

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A 7-year-old neutered female Boerboel cross was examined for progressive left pelvic limb lameness. There was no left patellar reflex but the remaining pelvic limb reflexes were hyperreflexic. Radiographically, there was a poorly mineralized opacity occupying the intervertebral foramen at LA-L5. On computed tomography images there was a hyperattenuating intramedullary lesion at LA-L5 that continued caudally, lateralized to the left and became extramedullary, terminating at L5-L6. In addition, well marginated, hyperattenuating lesions were noted at two muscular sites. The dog underwent euthanasia and a caudal esophageal mass was found at post mortem examination. The tumors in the spinal cord, the esophagus, and the skeletal muscles were diagnosed histologically as low-grade chondrosarcoma undergoing endochondral ossification. Spirocerca lupi-induced esophageal chondrosarcoma was believed to be the primary site from which the other, presumably metastatic, lesions originated.

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Section: Discussionmentioning

confidence: 99%

“…Approximately 17–20% of chondrosarcomas metastasize 4 . The most common site for metastasis is the lung but other sites have been reported 3,4,12 . In the dog, extraskeletal chondrosarcoma occurs more commonly in males, with patients commonly being middle to old aged 11 …”

Section: Discussionmentioning

confidence: 99%

Imaging Diagnosis-Spinal Cord Chondrosarcoma Associated With Spirocercosis in a Dog

Lindsay

Kirberger

Williams

2010

Veterinary Radiology &Amp; Ultrasound

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“…6 In dogs, ocular chondrosarcoma may be primary 7 or metastatic. 8 Primary ocular chondrosarcoma has also been reported in fish (Symphysodon aequifasciatus). 9 Neoplasms constitute 39% of the ocular alterations of the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW), an American reference laboratory in the field of ocular pathology.…”

Section: Introductionmentioning

confidence: 99%

“…The first descriptions of this unique ocular condition were only published several years later . In dogs, ocular chondrosarcoma may be primary or metastatic . Primary ocular chondrosarcoma has also been reported in fish ( Symphysodon aequifasciatus ) …”

Section: Introductionmentioning

confidence: 99%

Presumed post‐traumatic ocular chondrosarcoma with intrathoracic metastases in a cat

Moreira

Andrade

Fulgêncio³

et al. 2017

Veterinary Ophthalmology

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An indoor-only, 5-year-old, spayed female domestic shorthair cat presented for an ophthalmic examination of the left eye. An intraocular tumor with secondary glaucoma and blindness was diagnosed; the globe was enucleated and sent for histopathological examination. Gross examination revealed a solid white mass filling the entire vitreous space and replacing the iris and ciliary body. The lens and retina appeared to be similarly replaced by the neoplasm. Histological examination revealed a complete loss of the internal ocular structures, with a ruptured capsule as the only remnant of the lens within an extensive malignant mesenchymal neoplastic cell proliferation. The cells were polygonal, with well-defined cytoplasmic borders and abundant weakly basophilic cytoplasm, embedded within the islands of chondroid matrix. No neoplastic invasion of the sclera was apparent. The animal died 6 months after the enucleation due to respiratory distress. Gross examination revealed numerous firm, white to tan nodular masses with smooth to mildly irregular surfaces dispersed throughout the parietal pleura, thoracic surface of the diaphragm, tracheobronchial and mediastinal lymph nodes, pericardium, and lungs. On cross-section, the neoplastic nodules were solid and variably translucent, resembling hyaline cartilage. Histologically, these nodules were similar to the neoplasm identified earlier in the left globe. Metastasis of post-traumatic ocular chondrosarcoma has not yet been described in cats. This is therefore believed to be the first report of metastases of this type of neoplasm in cats. This case adds to the limited set of data on the outcome of this type of tumor.

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“…Other secondary intraocular neoplasms to be considered include chondrossarcoma ( Figure 1H), hemangiosarcoma, cutaneous and oral melanoma, malignant histiocytosis, seminoma, transitional cell carcinoma of the urinary bladder, as well as the urethra, neurogenic sarcoma, osteosarcoma, rhabdomyosarcoma, anaplastic fibrosarcoma, pheochromocytoma, and adenocarcinoma of mammary gland, thyroid gland, parotid salivary gland, and of nasal, renal, and pancreatic origin (RODRIGUES Jr. et al, 2009). …”

Section: Secondary Neoplasmsmentioning

confidence: 99%