Metastatic genitourinary cancer diagnosed by body fluid cytology: clinicopathologic and cytomorphologic correlation

Raymond, Sasha; Au, Kaylene; Fu, Ryan; Tauchi-Nishi, Pamela

doi:10.1016/j.jasc.2016.11.001

Cited by 4 publications

(7 citation statements)

References 21 publications

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“…A predominant individual cell distribution, short cellular cords, cellular windows, cell wrapping, and cytoplasmic vacuolization with signet ring cells have been mentioned as suggestive features. [5][6][7] It interesting to note that these findings were all present in our case. However, probably the most relevant diagnostic feature are MWB.…”

supporting

confidence: 69%

“…However, reflecting the rarity of pleural involvement by urothelial carcinoma few reports are available. Interestingly, two recent cytologic series describing 28 cases of urothelial carcinoma in effusions do not mention MWB 6,7 . We recently observed a case of metastatic urothelial carcinoma with ascites and a pleural effusion.…”

Section: Figurementioning

confidence: 92%

“…Interestingly, two recent cytologic series describing 28 cases of urothelial carcinoma in effusions do not mention MWB. 6,7 We recently observed a case of metastatic urothelial carcinoma with ascites and a pleural effusion. In both samples, MWB were a common finding that oriented immunocytochemical studies, allowing a precise diagnosis.…”

mentioning

confidence: 99%

“…Unfortunately, they seem to be absent in many cases. 6,7 MWB should not be confused with the intracytoplasmic targetoid mucin vacuoles that are sometimes seen in fine needle aspiration samples of urothelial carcinoma. 8 These resemble those seen in lobular breast carcinoma and are not common in urine or effusion samples.…”

mentioning

confidence: 99%

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Melamed–Wolinska bodies in a pleural effusion

Gordillo

Jiménez‐Heffernan

2022

Diagnostic Cytopathology

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supporting

confidence: 69%

Section: Figurementioning

confidence: 92%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Melamed–Wolinska bodies in a pleural effusion

Gordillo

Jiménez‐Heffernan

2022

Diagnostic Cytopathology

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“…A search of PubMed for publications focused on the distribution of malignant effusions published in the past two decades in the English language resulted in individual case reports, original studies consisting of relatively low number of malignant specimens, and limited reviews 2‐12 . To investigate how the incidence of different types of malignancy involving malignant effusions has changed, Dermawan et al conducted a study consisting of malignant pleural, peritoneal and pericardial effusions diagnosed during a 17‐year (2000‐2016) period.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and categorization of malignant effusions: A 6‐year review from a single academic institution

Lew

Cantley

Heider

et al. 2020

Diagnostic Cytopathology

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Background Cytologic detection of malignant cells in pleural, peritoneal, or pericardial effusion most likely indicates advanced stage of malignant disease. There are a few studies updating the categorization of malignant effusions. Methods The electronic pathology database was searched to identify consecutive cases of malignant effusion during a 6‐year period. Patient age and gender, origins of known malignancy, and cytologic diagnoses were recorded and summarized. Results A total of 1059 specimens included 561 (53%) pleural, 441 (41.6%) peritoneal, and 57 (5.4%) pericardial fluids. Most of the pleural (516, 92.0%), peritoneal (418, 94.8%), and pericardial (53, 93.0%) specimens were derived from patients with a single known malignancy. More common origins involving pleural fluid were lung (152, 27.1%) followed by breast (103, 18.4%) and gastrointestinal tract (76, 13.5%). The most common etiology for women and men was breast (102, 30.8%) and lung (67, 36.2%), respectively. More common origins involving peritoneal fluid were gastrointestinal (158, 35.8%) and gynecologic (156, 35.4%) tracts, and breast (46, 10.4%). The most common etiology for women and men was Mullerian (156, 55.5%) and gastrointestinal tract (94, 68.6%), respectively. Most common origins involving the pericardial fluid were breast (20, 37.7%) and lung (17, 29.8%). Breast and lung were the most common etiology for women (20, 57.1%) and men (8, 44.4%), respectively. Conclusions Breast and lung remain to be the most common origin of both malignant pleural and pericardial effusion for women and men, respectively. The most common origin involving peritoneal effusion is Mullerian for women and gastrointestinal tract for men.

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