Metastatic Crohns disease in pediatrics

Blasco‐Alonso, Javier; Fernández-Crehuet, F. Girón; Ramirez, Miguel Angel Lendinez; S, Gutiérrez; Pérez, Silvia Luque; Nieto, Juliana Serrano; López, Víctor Manuel Navas; Salinas, C. Sierra

doi:10.17235/reed.2016.3948/2015

Cited by 7 publications

(15 citation statements)

References 13 publications

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“…Infliximab is often used in children and initially works well, although disease recurs in 33%‐50% of patients within 5 years . Most cases of adalimumab use in cutaneous CD have been described in adults, but Blasco and colleagues describe a child whose cutaneous lesions improved with adalimumab . In severe cases, clinicians can consider surgical debridement or hyperbaric oxygen .…”

Section: Treatmentmentioning

confidence: 99%

“…11,15,27 Most cases of adalimumab use in cutaneous CD have been described in adults, but Blasco and colleagues describe a child whose cutaneous lesions improved with adalimumab. 28 In severe cases, clinicians can consider surgical debridement or hyperbaric oxygen. 11 For patients with granulomatous lymphangitis with genital edema, circumcision is an appropriate treatment option if clinically appopriate.…”

Section: (Continues)mentioning

confidence: 99%

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Cutaneous manifestations of metastatic Crohn's disease

Schneider

Foster²,

Patel

et al. 2018

Pediatric Dermatology

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Metastatic Crohn's disease is a rare cutaneous complication of primary Crohn's disease. It is a granulomatous inflammatory process, similar to the pathogenic mechanism of Crohn's disease, that occurs in sites discontiguous from the gastrointestinal tract. Metastatic Crohn's disease can precede the development of Crohn's disease by months to years, and children are more likely to present with metastatic Crohn's disease in the absence of gastrointestinal symptoms. Given that approximately 30% of individuals with Crohn's disease present in childhood, early recognition of extraintestinal manifestations of Crohn's disease such as metastatic Crohn's disease can aid in timely diagnosis and management of bowel disease. We present data from two pediatric cases of metastatic Crohn's disease recently seen at our institution in addition to the 61 reported cases of pediatric metastatic Crohn's disease in the literature. This review article will focus on the epidemiology, pathogenesis, clinical features, and histology of and treatment options for pediatric metastatic Crohn's disease.

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Section: Treatmentmentioning

confidence: 99%

Section: (Continues)mentioning

confidence: 99%

Cutaneous manifestations of metastatic Crohn's disease

Schneider

Foster²,

Patel

et al. 2018

Pediatric Dermatology

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“…Metastatic Crohn’s Disease (MCD) is a granulomatous dermatitis characterized by the presence of non-caseation granulomatous inflammation occurring at a distance from the gastrointestinal tract. It manifests as plaques, abscesses, swelling, or fissures mainly on the arms, legs, and face [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

“…Blasco Alonso et al reported a group of four pediatric patients diagnosed with MCD, three of whom were diagnosed prior to the IBD diagnosis. In this lot, the lesions were distributed in the genital area in three patients and in the bilateral pretibial region in one patient [ 17 ].…”

Section: Resultsmentioning

confidence: 99%

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Dermatological Manifestations in Pediatric Inflammatory Bowel Disease

et al. 2020

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Background and Objectives: Over the last years, inflammatory bowel disease (IBD) has been reported on a high incidence in pediatric populations and has been associated with numerous extraintestinal manifestations, making its management a real challenge for the pediatric gastroenterologist. Dermatological manifestations in IBD are either specific, related to the disease activity or treatment-associated, or non-specific. This literature review aims to identify and report the dermatological manifestations of IBD in children, the correlation between their appearance and the demographical characteristics, the relationship between these lesions and disease activity, and to highlight the impact of dermatological manifestations on an IBD treatment regime. Materials and Methods: A systemic literature review was performed, investigating articles and case reports on dermatological manifestations in children with IBD starting from 2005. A total of 159 potentially suitable articles were identified and after the exclusion process, 75 articles were selected. Results: The most common dermatological manifestations reported in pediatric IBD are erythema nodosum and pyoderma gangrenosum. More rare cases of metastatic Crohn’s disease, epidermolysis bullosa acquisita, small-vessel vasculitis, necrotizing vasculitis, leukocytoclastic vasculitis, cutaneous polyarteritis nodosa, and Sweet’s syndrome have been reported. Oral manifestations of IBD are divided into specific (tag-like lesions, mucogingivitis, lip swelling with vertical fissures, aphthous stomatitis, and pyostomatitis vegetans) and non-specific. IBD treatment may present with side effects involving the skin and mucosa. Anti-tumor necrosis factor agents have been linked to opportunistic skin infections, psoriasiform lesions, and a potentially increased risk for skin cancer. Cutaneous manifestations such as acrodermatitis enteropathica, purpuric lesions, and angular cheilitis may appear secondary to malnutrition and/or malabsorption. Conclusions: The correct diagnosis of dermatological manifestations in pediatric IBD is of paramount importance because of their impact on disease activity, treatment options, and a patient’s psychological status.

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Metastatic Crohns disease in pediatrics

Cited by 7 publications

References 13 publications

Cutaneous manifestations of metastatic Crohn's disease

Cutaneous manifestations of metastatic Crohn's disease

Dermatological Manifestations in Pediatric Inflammatory Bowel Disease

Multiple drugs

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Metastatic Crohns disease in pediatrics

Cited by 7 publications

References 13 publications

Cutaneous manifestations of metastatic Crohn's disease

Cutaneous manifestations of metastatic Crohn's disease

Dermatological Manifestations in Pediatric Inflammatory Bowel Disease

Multiple drugs

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Metastatic Crohns disease in pediatrics