Cutaneous manifestations of metastatic Crohn's disease

Schneider, Samantha L.; Foster, Katharine; Patel, Devika; Shwayder, Tor

doi:10.1111/pde.13565

Cited by 49 publications

(77 citation statements)

References 60 publications

(125 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Perhaps its use is best restricted to high‐risk conditions (e.g. cutaneous or metastatic CD, 30 chronic cheilitis and stomatitis, or genital lymphoedema 31 ) to direct which patients might need a gastrointestinal referral. There are currently no data to support this, and the literature would suggest FCP has not altered the management or investigation of IBD in dermatology so far.…”

Section: Discussionmentioning

confidence: 99%

Faecal calprotectin in dermatology practice

Premjeyanth

Shipman

2020

Clin Exp Dermatol

View full text Add to dashboard Cite

Summary Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory condition of the bowel with two primary subtypes: Crohn disease and ulcerative colitis. Extraintestinal manifestations are common in IBD and, after musculoskeletal involvement, dermatological lesions are the most common. Currently, colonoscopy and biopsy are the most definitive tests for a diagnosis of IBD. However, in the past decade, faecal markers have emerged as new diagnostic tools to detect and monitor intestinal inflammation, and faecal calprotectin (FCP) in particular has gained popularity owing to its high sensitivity and specificity for detection of organic bowel disease. This review aims to explore whether there is a role for FCP measurement when encountering cutaneous manifestations associated with IBD.

show abstract

Section: Discussionmentioning

confidence: 99%

Faecal calprotectin in dermatology practice

Premjeyanth

Shipman

2020

Clin Exp Dermatol

View full text Add to dashboard Cite

show abstract

“…While most patients with MCD carry a previous diagnosis of Crohn's disease, some patients present without classic gastrointestinal manifestations [4]. The clinical characteristics of MCD also vary, suggesting that the disease may be underrecognized due to misdiagnosis [5]. Herein, we report a rare presentation of MCD with involvement of the breast and genital regions in the absence of active intestinal manifestations.…”

Section: Introductionmentioning

confidence: 92%

A Rare Clinical Presentation of Metastatic Crohn’s Disease

Streight¹,

Braun²,

Lowe³

et al. 2020

Cureus

View full text Add to dashboard Cite

A 31-year-old female with a history of systemic lupus erythematous, IgA nephropathy, and psoriasis presented with a one-month history of a painful, pruritic rash under the bilateral breasts and in the genital region. Cutaneous examination revealed a large, tender ulcer under the left breast with a shiny erythematous base and peripheral hypertrophic changes. Small ulcers were present on the bilateral inguinal folds, and the labia majora were edematous with multiple erythematous papules. Histological examination of the left breast revealed ulceration with granulomatous dermatitis, consistent with a diagnosis of metastatic Crohn's disease. Metastatic Crohn's disease is a rare cutaneous manifestation of Crohn's disease characterized by non-caseating granulomas in regions non-contiguous with the gastrointestinal tract. At the time of diagnosis, our patient reported no gastrointestinal symptoms aside from occasional blood-streaked stools from hemorrhoids. This case demonstrates the importance of considering the disease when a patient presents with intertriginous or genital lesions, even in the absence of systemic manifestations.

show abstract

“…Establishing the diagnosis is especially important in the absence of gastrointestinal symptoms. Children in particular frequently experience no gastrointestinal complaints . Cutaneous findings are usually characterized by erythema and edema with fissures and ulcerations in the genital and – less frequently – extragenital region .…”

Section: Granulomatous Dermatoses In Systemic Diseasementioning

confidence: 99%

Non‐infectious granulomatous dermatoses

Schmitt¹,

Völz

2019

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Summary Granulomatous dermatoses comprise a wide range of etiologically and clinically distinct skin diseases that share a common histology characterized by the accumulation of histiocytes include macrophages. While the pathogenesis of these disorders is not fully understood, the underlying mechanism is thought to involve a reaction pattern caused by an immunogenic stimulus. Antigen‐presenting cells and the effect of various cytokines play a key role. Our understanding of granulomatous reaction patterns has been advanced by insights drawn from observations of such reactions in patients on immunomodulatory therapy and in individuals with genetic immunodeficiency. Traditionally, a distinction is made between infectious and non‐infectious granulomatous dermatoses. The present CME article addresses granulomatous skin diseases for which there is no evidence of a causative infectious agent. Common representatives include granuloma annulare, necrobiosis lipoidica and cutaneous sarcoidosis. Granulomatous dermatoses may be part of the clinical spectrum of various systemic disorders or may be associated therewith. Some neoplastic disorders may mimic granulomatous dermatoses histologically. Given the pathogenetic diversity involved, the clinical presentation, too, is quite varied. Overall, however, each disorder is characterized by typical clinical features. The diagnosis always requires thorough clinicopathologic correlation. Treatment is preferably based on the underlying pathogenesis and frequently involves anti‐inflammatory agents. In most cases, however, there is insufficient study data. The dermal nature of these disorders frequently poses a therapeutic challenge, especially with respect to topical treatment.

show abstract

Cutaneous manifestations of metastatic Crohn's disease

Cited by 49 publications

References 60 publications

Faecal calprotectin in dermatology practice

Faecal calprotectin in dermatology practice

A Rare Clinical Presentation of Metastatic Crohn’s Disease

Non‐infectious granulomatous dermatoses

Contact Info

Product

Resources

About