Metastatic Crohn′s disease

Abstract

Crohn's disease, first described in 1922, is characterized by segmental granulomatous inflammation of the intestinal tract and frequently involves the cutaneous tissues as well. Cutaneous Crohn's disease (CCD) is synonymous with metastatic Crohn's disease (MSD). A case of CCD, without any gastrointestinal involvement is reported for its rarity.

Vegetating plaques in the groin: A manifestation of metastatic crohn's disease

“…[ 1 7 ] Atypical genital lesions may mimic a variety of dermatoses. These include labial edema mimicking lymphedema,[ 8 ] knife cut ulcers, and hypertrophic exophytic variants. [ 9 ]…”

“…The age of onset ranged from 29 to 39 years in adults, whereas children between 10 and 14 years were usually affected. [ 2 8 ]…”

“…The other drugs which have been tried include sulfasalazine, azathioprine, cyclosporine, intravenous infliximab, adalimumab, mycophenolate mofetil, oral zinc sulfate, and hyperbaric oxygen therapy. [ 2 4 8 9 ]…”

Cutaneous Crohn's disease successfully treated with adalimumab

“…Editor Dialysis-related amyloidosis (DRA) is a disabling disease characterized by tissue deposition of b 2 -microglobuline in the bone, periarticular structures and viscera of patients with long-term haemodialysis. 1,2 Although the most common symptoms of DRA are shoulder pain and carpal tunnel syndrome, 3 skin involvement can occur and disease control is difficult. 4,5 Here, we report a case of extensive subcutaneous masses on the buttocks caused by long-term haemodylasis, which led to the death of the patient.…”

“…Muco-cutaneous lesions are typically ulcers, erythematous nodules and small 'knife cut' type erosions localized in flexural areas; the latter represent the specific feature of CCD. 2 A 70-year-old white man presented to us with a 6-year history of two specular painless nodular-ulcerative lesions with indurated borders and base covered by purulent exudate affecting intergluteal region ( Fig. 1a).…”