Metastatic Crohn's disease

Extensive Necrobiosis in Metastatic Crohn’s Disease

“…The previous reports emphasized that the sarcoid granulomas neither showed central caseation nor zones of necrobiosis even when the biopsies were taken from the bord er of ulcerations [3,4,10,12]. In our case, however, extensive necrobiosis of large der mal areas is the main feature.…”

“…He ob served 3 patients with Crohn's disease and skin manifestations in different locations which histologically showed non-caseating granulomas of sarcoid structure. Since then about 15 similar cases have been reported [2][3][4][5][6][7][9][10][11][12],…”

“…Furthermore, skin changes were seen which histologically showed sarcoid granulomas typical of Crohn's disease of the intestine. The phenomenon of sarcoid granulomas in skin lesions not adjacent to the gastrointestinal tract was named 'metastatic Crohn's dis ease' (MCD) [3]. It was stressed that these granulomas did neither show central casea tion nor zones of necrobiosis [3][4][5][6][7], This report describes the case of a 33-year-old woman with Crohn's disease of the intestine and ulcerative nodules of the skin which histologically showed pro nounced areas of necrobiosis in addition to the typical sarcoid granulomas.…”

Painful Lesions in the Genital Area of a Young Woman

“…1 Although CD most commonly affects the small bowel, cutaneous CD occurs more frequently in patients with colorectal disease. 2 There does not seem to be a relationship between flares in GI disease activity and occurrence of skin lesions. The most common skin lesions are contiguous perianal lesions caused by direct extension of intestinal disease.…”

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“…In the literature the following cutaneous and mucocutaneous changes are discussed: perianal fistula and ulcera, peristomal ulcera, erythema nodosum, pyoderma gangraenosum, cheilitis granulomatosa, periarteriitis nodosa, oral aphthae as well as erythema exsudativum multiforme-like skin disturbances [4,5,8,12,16]. Infiltrates of the integument which are separated from the gastrointestinal tract by healthy skin are called "metastatic Crohn's disease" [6,10,13,16].…”