Metastatic breast cancer presenting as linitis plastica of the stomach

Whitty, Lisa A.; Crawford, D. L.; Woodland, J.; Patel, Jitendra; Nattier, Bryce; Thomas, Charles R.

doi:10.1007/s10120-005-0334-7

Cited by 16 publications

(10 citation statements)

References 3 publications

(4 reference statements)

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“…Other authors showed that the most common type of gastric metastasis of breast cancer (73-83%) is linitis plastica (34)(35)(36).…”

Section: Diagnosticmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

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patologic corect, imunohistochimia ne oferă un diagnostic de certitudine. Introducerea unui protocol de supraveghere endoscopică pentru pacienţii cu cancer lobular de sân ar putea fi o propunere pentru detectarea precoce a metastazelor gastrice care să permită o terapie adecvată.Cuvinte cheie: metastaze gastrice, cancer de sân lobular, teste imunohistochimice, endoscopie superioară Abstract Introduction: The predilection of lobular invasive breast cancer metastasis for the stomach is a topic that has succumbed to various assumptions over the time. Background and Aims: Gastric metastasis of lobular breast cancer is unusual and it can be diagnosed after a long period of time from primary tumor diagnosis. The aim of this study was to review current knowledge regarding the current methods of diagnosis and treatment of gastric metastasis of breast cancer. Methods: A systematic literature search was performed in the Pub-Med -Medline database using the terms "gastric metastasis of lobular breast cancer" and "gastric metastasis features" to identify articles relevant to gastric metastasis of lobular breast cancer. Results: Several papers have shown that the topic is rarely presented in the form of case presentations or miniseries by summing up sporadic cases. Due to its rarity and metastasis specificity as host type and appearance after latency of lobular breast cancer makes its gastric metastasis considered atypical and occasionally confused with a primary stomach malignancy. The most recent articles present the immunohistochemical diagnostic criteria of this clinical entity and a new therapeutic approach. Conclusion: At patients with gastric metastasis of lobular breast cancer, obtaining pathologic material and biopsies interpretation can be a real challenge for getting a correct pathologic diagnosis, immunohistochemistry gives us definite diagnosis. The introduction of an endoscopic surveillance protocol for patients with lobular breast cancer could be a proposal for the detection of early gastric metastases allowing for appropriate therapy.

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“…Other authors showed that the most common type of gastric metastasis of breast cancer (73-83%) is linitis plastica (34)(35)(36).…”

Section: Diagnosticmentioning

confidence: 99%

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Bîrlă¹,

Dinu²,

Iosif³

et al. 2019

chr

View full text Add to dashboard Cite

show abstract

“…Though metastatic breast cancer to the stomach is rare, invasive lobular subtypes are known to metastasize to the gastrointestinal tract and can occur years after the initial cancer treatment [ 1 – 4 ]. Clinical manifestations can be vague with varying endoscopic and radiologic appearances, with diffuse infiltrating disease most commonly seen [ 5 – 7 ]. Endoscopic mucosal biopsies often confirm the diagnosis, though some patients require deep biopsies or surgical biopsies due to tumor infiltration of layers deep to the mucosa [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Use of Endoscopic Ultrasound in a Diagnostic Dilemma: Metastatic Breast Cancer to the Stomach

Ulmer

Cormier

Jha

et al. 2018

Case Reports in Gastrointestinal Medicine

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A 55-year-old woman presented with persistent nausea, vomiting, and weight loss previously attributed to Ménétrier's disease. On further workup, she was found to have metastatic lobular breast carcinoma causing gastric outlet obstruction, diagnosed by endoscopic ultrasound with fine needle aspiration after previous gastric mucosal biopsies were unremarkable. In most reported cases of gastric metastasis from breast cancer, a diagnosis was established by mucosal biopsy. This case is an important reminder that mucosal biopsies can be negative in about 20% of patients with gastric metastasis, which may lead to a delay in diagnosis and treatment. Gastroenterologists should be diligent in taking deeper biopsies if there is a suspicion for gastric metastasis.

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“…Furthermore, ILC metastasis to the stomach was more frequent when considering pathological type. There are several case reports including only a few cases due to low incidence of breast cancer with gastric metastasis (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Taal et al (21) reported 51 cases of breast cancer with gastric metastasis, and 36 of the 51 patients had ILC.…”

Section: Discussionmentioning

confidence: 99%

“…The most common metastatic sites of breast cancer are the bone, brain, liver and lung, however, patterns of metastasis are affected by the breast cancer subtype (3)(4)(5). By contrast, breast cancer rarely metastasizes to the gastrointestinal tract, including the stomach, and few studies and case reports concerning gastric metastasis from breast cancer can be found (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Chemokines and their receptors, including CXCR4 and CCR7, are critical for regulating the location of metastasis.…”

Section: Introductionmentioning

confidence: 99%

Clinical features and prognosis of breast cancer with gastric metastasis

et al. 2018

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Breast cancer rarely metastasizes to the gastrointestinal tract, including the stomach. Due to the rarity of this metastasis, it is occasionally confused with a primary stomach malignancy. However, discriminating characteristic features with clinical implications may exist. The aim of the current study was to analyze the clinical features and prognosis of breast cancer with gastric metastasis. Between January 1994 and October 2016, 13 patients at Samsung Medical Center (Seoul, Korea) were clinically or pathologically determined to have breast cancer with gastric metastasis. The present study retrospectively collected clinicopathological data from the electronic medical records of these 13 female patients. At breast cancer diagnosis, the median patient age was 45 years. A total of 7 patients (53.8%) presented with invasive lobular carcinoma (ILC) and 6 (46.2%) with invasive ductal carcinoma. Of the 13 patients, 11 were stage I-III at initial breast cancer diagnosis and underwent surgery. Positivity of breast cancer tissue samples for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) was 92.3, 76.9 and 0%, respectively. Positivity of gastric metastasis lesions, based on immunohistochemistry results, was 81.8, 50 and 0% for ER, PR and HER2, respectively. The stomach was the location of the first metastatic lesion in 6 out of the 11 patients (54.5%) with de novo stage I-III cancer. The median time interval from initial breast cancer diagnosis to stomach metastasis was 77.5 months. The 3-year survival rate was 79.1%, and the estimated mean survival time was 35.1 months. Breast cancer with gastric metastasis is rare, and due to this fact, a thorough pathological review and greater clinical suspicion are required in these cases.

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Metastatic breast cancer presenting as linitis plastica of the stomach

Cited by 16 publications

References 3 publications

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Gastric Metastasis of Invasive Lobular Breast Carcinoma, a Current Diagnostic and Treatment Challenge - A Review

Use of Endoscopic Ultrasound in a Diagnostic Dilemma: Metastatic Breast Cancer to the Stomach

Clinical features and prognosis of breast cancer with gastric metastasis

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