Metastasizing Pleomorphic Adenoma of the Nasal Septum

Freeman, Stephen B.; Kennedy, Kevin S.; Parker, Gregg S.; Tatum, Sherard A.

doi:10.1001/archotol.1990.01870110103014

Cited by 67 publications

(29 citation statements)

References 9 publications

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“…The predominant metastatic site is bone but spread to lungs, regional lymph nodes and liver has been seen. (8) Ten cases of metastasising pleomorphic adenoma of the parotid gland and three patients with metastatic pleomorphic adenoma of the minor salivary glands have been reported in the literature. (9) FINAL DIAGNOSIS Pleomorphic adenomas are rare tumours of the nasal cavity.…”

Section: Resultsmentioning

confidence: 99%

Pleomorphic Adenoma of the Nasal Septum- A Case Report

Mathew¹,

Velankar²,

Shetty³

et al. 2017

jemds

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PRESENTATION OF CASEA 43-year-old male patient presented with a 1.5-year history of progressive left nasal septal mass (Fig.1) leading to left nasal obstruction for the last 1-1.5 years, two to three episodes of mild epistaxis and gradually enlarging mass involving the left nasal cavity. There was no history of previous trauma, surgeries or visual defect. His general health was satisfactory with a stable weight. DIFFERENTIAL DIAGNOSISSalivary gland tumours account for about 3% of all neoplasms, the majority being benign and about 70% are pleomorphic adenomas. A small minority are also located in nasal cavity, neck and oral cavity. In this case report, we are presenting a rare case of pleomorphic adenoma of the nasal septum. Nasal septum is a discrete area of erectile tissue in the submucosa over the anterior nasal septum. In most cases, it can present as a suspicious lesion. Several benign lesions of the septum like leiomyoma, osteochondroma and transitional cell papilloma can be considered. Other malignant tumours such as melanoma, adenoid cystic carcinoma and squamous cell carcinomas may be the differential diagnosis. The majority of these tumours arise from the mucosa of the bony and cartilaginous septum. However, depending on the size and location, the diagnosis may be considered. 'Financial or Other Competing Interest': None. Submission 09-09-2017, Peer Review 03-10-2017, Acceptance 09-10-2017, Published 30-10-2017 CLINICAL DIAGNOSISThe lateral wall of nasal cavity was splayed laterally by a mass within the left nasal cavity, while the skin over the swelling appeared normal. Anterior rhinoscopy revealed a friable polypoid mass involving the left nasal cavity. A probe could not be passed around the mass, neither did it bleed on manipulation. The mass appeared to arise from the nasal septum but caused minimal or almost no deviation of the nasal septum to the opposite side. There was no evidence of rhinosinusitis and his postnasal space was also normal. There were no palpable lymph nodes. Radiological examination (CT scan) demonstrated a well-defined cystic mass in the anterior part of the septum of the left nasal cavity with well pneumatised paranasal sinuses (Fig. 2). Furthermore, the smooth surface, preservation of mucosal lining and the localised nature of the mass seen in nasal endoscopy were consistent with the benign lesion. DISCUSSION OF MANAGEMENTAn intranasal resection of the mass was done and the sample (Fig. 3, 4) was sent for biopsy. The histopathological analysis of the tumour confirmed a benign pleomorphic adenoma with no focus of malignant change. The patient was discharged on day 3, and the postoperative course was uneventful. After a month, on followup, the patient had no nasal complaints (Fig.

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Section: Resultsmentioning

confidence: 99%

Pleomorphic Adenoma of the Nasal Septum- A Case Report

Mathew¹,

Velankar²,

Shetty³

et al. 2017

jemds

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“…5 While these tumors are typically benign, they can be locally aggressive and even metastatic. 6 Pleomorphic adenoma of the nasal septum tends to present between the third and sixth decades of life. Unilateral nasal obstruction and intermittent epistaxis are the most common presenting symptoms.…”

Section: Discussionmentioning

confidence: 99%

A Large Submucosal Mass With Prominent Superficial Vessels

Greene

Topf

Meyers

et al. 2014

JAMA Otolaryngol Head Neck Surg

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“…Se ha reportado un caso de una metástasis cervical de un AP recurrente de la cavidad nasal histológicamente benigna, luego de 17 años de haberlo extirpado. Se cree que durante la escisión de la masa nasal se sembraron células tumorales 24 . Dos neoplasias del septum nasal han sido descritas como carcinomas ex-AP de la mucosa nasal.…”

Section: Discussionunclassified

Adenoma pleomorfo del septum nasal, dos casos clínicos y revisión del tema

M²,

Z³

et al. 2011

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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El tumor benigno más frecuente de las glándulas salivales mayores es el adenoma pleomorfo. Además de las glándulas salivales mayores, también puede ocurrir en las glándulas salivales del paladar duro y blando. Raros casos se han reportado en la nasofaringe, orofaringe, hipofaringe y laringe. Adenomas pleomorfos intranasales son muy infrecuentes y pueden ser mal diagnosticados debido a que tienen mayor celularidad mioepitelial y poco estroma mixoide, en comparación con los que se localizan en otros lugares. Presentamos dos raros casos de adenomas pleomorfos del septum nasal y analizamos los hallazgos patológicos y el manejo clínico. Se revisa la literatura en relación al tema.Palabras clave: Adenoma pleomorfo, septum nasal, glándula salival. ABSTRACTThe most common benign tumor of major salivary glands is the pleomorphic adenoma. In addition to the major salivary glands may also occur in the salivary glands of hard and soft palate. Rare cases have been reported in the nasopharynx, oropharynx, hypopharynx and larynx. Intranasal pleomorphic adenomas are very rare and can be misdiagnosed because they have greater myoepithelial cellularity and little myxoid stroma, compared with those located elsewhere. We report two rare cases of pleomorphic adenomas of the nasal septum and analyze the pathological findings and clinical management. We review the literature on the subject.

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Metastasizing Pleomorphic Adenoma of the Nasal Septum

Cited by 67 publications

References 9 publications

Pleomorphic Adenoma of the Nasal Septum- A Case Report

Pleomorphic Adenoma of the Nasal Septum- A Case Report

A Large Submucosal Mass With Prominent Superficial Vessels

Adenoma pleomorfo del septum nasal, dos casos clínicos y revisión del tema

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