Metastasizing placental site trophoblastic tumor: A case study

Eckstein, Robert P.; Russell, Peter; Friedlander, Michael; Tattersall, Martin H. N.; Bradfield, Alan

doi:10.1016/s0046-8177(85)80114-3

“…As observed in our cases, necrosis is more extensive in the malignant tumors, compared with benign ones limited to the uterus [2,8,24]. Pleomorphism and vascular invasion are common features of PSTT, but have no prognostic significance.…”

Section: Discussionsupporting

confidence: 53%

Metastasizing placental site trophoblastic tumor: Immunohistochemical and DNA analysis 2 case reports and a review of the literature

Remadi

¹

,

Lifschitz-Mercer

²

,

Ben-Hur

³

et al. 1997

Arch Gynecol Obstet

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Abstract. Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.

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“…In a recent review of cases, Lathrop et al reported a 20% fatality rate in patients with PSTT ~2). At least 17 cases of metastatic PSTT have been previously reported, with a high fatality rate (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Chemotherapy has had limited success in metastatic PSTT, although one complete and some partial re-Address for correspondence: Laurel A.…”

mentioning

confidence: 99%

Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor

King

¹

,

Okagaki

²

,

Twiggs

³

1992

Int J Gynecol Cancer

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Placental site trophoblastic tumor (PSTT), a rare variant of gestational trophoblastic disease, was first described in 1976. PSTT is usually seen in young women, generally treated by hysterectomy, and is associated with a 20% fatality rate. The development of metastases secondary to PSTT is associated with an extremely poor prognosis. Metastatic PSTT has generally been resistant to chemotherapy although one complete and some partial responses have been noted previously. We report a case of a complete chemotherapeutic response in a patient with pulmonary metastases.

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“…Including our cases, approximately 21 cases of metastatic PSTT have been reported [17,21]. Lung metastases have been described only in a few cases [1,2,5,8,10,17].…”

Section: Discussionmentioning

confidence: 76%

Metastasizing placental site trophoblastic tumor: immunohistochemical and DNA analysis. 2 case reports and a review of the literature

Remadi

¹

,

Lifschitz-Mercer

²

,

Ben-Hur

³

et al. 1997

Archives of Gynecology and Obstetrics

View full text Add to dashboard Cite

Abstract. Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.

show abstract

Metastasizing placental site trophoblastic tumor: A case study

Cited by 47 publications

References 11 publications

Metastasizing placental site trophoblastic tumor: Immunohistochemical and DNA analysis 2 case reports and a review of the literature

Metastasizing placental site trophoblastic tumor: Immunohistochemical and DNA analysis 2 case reports and a review of the literature

Resolution of pulmonary metastases with chemotherapy in a patient with placental site trophoblastic tumor

Metastasizing placental site trophoblastic tumor: immunohistochemical and DNA analysis. 2 case reports and a review of the literature

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