Metastasizing placental site trophoblastic tumor: Immunohistochemical and DNA analysis 2 case reports and a review of the literature

Remadi, Sami; Lifschitz-Mercer, Beatriz; Ben-Hur, H; Dgani, R.; Czernobilsky, Bernard

doi:10.1007/bf02505316

Cited by 13 publications

(1 citation statement)

References 18 publications

(23 reference statements)

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“…Recently, studies on hPL have focused on its expression in placental site trophoblastic tumors (PSTTs), and several papers have established a strong expression of hPL in PSTTs [ 4 , 26 , 27 ]. A recent study on hPL has discussed the use of immunohistochemistry for hPL as a diagnostic method for PSTT with about 60% specificity [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

The Pattern of Expression of Human Placental Lactogen Across Normal, Lactational, and Malignant Mammary Epithelium

Alyusuf¹,

Wazir²,

Brahmi³

et al. 2023

Cureus

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The immunoexpression of human placental lactogen (hPL) in mammary epithelium is not well studied in the literature. Our overall objective was to delineate the distribution pattern of hPL across mammary epithelia of varying levels of differentiation. This is the first research to study the level of expression of hPL in human lactational change epithelium. Immunohistochemistry (IHC) for hPL was performed on archival formalinfixed paraffin-embedded tissue blocks of 97 cases. These consisted of 53 invasive ductal carcinomas, 21 lactational change cases, and 23 cases of normal mammary tissue. The results of this study show underexpression of hPL in malignant epithelium compared to normal and lactational groups individually and combined as a non-malignant group. However, a higher expression of hPL was noted in mammary carcinoma of axillary lymph node (ALN)-positive patients compared to ALN-negative cases. There was no statistically significant difference between hPL expression and tumor grade, estrogen receptors (ER), progesterone receptors (PR), or human epidermal growth factor receptor 2 (HER2) status. The comparison of the immunoexpression of hPL in malignant epithelium versus lactational change epithelium may provide the basis for future studies on the possible role of hPL in the protective mechanism of lactation tissue from carcinogenesis. Our results could be explained by the proposed mechanism in the literature, which is that breast cancer cells have a potential inhibitory effect on the translation of human chorionic somatotropin hormone (CSH) mRNA into hPL protein. Our results support the literature findings of a poorer prognostic outcome for breast malignancies when hPL is expressed but require further studies using a more comprehensive range of clinical parameters.

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Section: Discussionmentioning

confidence: 99%

The Pattern of Expression of Human Placental Lactogen Across Normal, Lactational, and Malignant Mammary Epithelium

Alyusuf¹,

Wazir²,

Brahmi³

et al. 2023

Cureus

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Malignant placental site trophoblastic tumor

Xue

Guan

Ngan

et al. 2002

Cancer

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BACKGROUND Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasm composed predominantly of intermediate trophoblast. Most showed benign behavior whereas 10–15% of PSTTs were clinically malignant with later recurrence and metastasis. Currently, there are no reliable means to predict clinical outcome, and cytogenetic information is scanty. METHODS The clinicopathologic features of two cases of malignant PSTT were analyzed. Cytogenetic analysis was performed by comparative genomic hybridization (CGH) and chromosome in situ hybridization (CISH) using frozen tissue and paraffin embedded sections, respectively. RESULTS Both patients were 32 years old at time of diagnosis. One patient with PSTT presented with menorrhagia, and the other presented with symptoms of missed abortion. Elevated serum human chorionic gonadotropin (HCG) was detected in both patients. Histologic examination showed the typical features of PSTT with high mitotic count (> 5/10 high‐power fields). Ovarian and lung metastasis occurred in both patients. Immunohistochemical staining revealed an equal distribution of HCG and human placental lactogen. Cytogenetic studies by CISH showed that karyotypes of these two malignant PSTTs were diploid. Analysis of the tumor tissue by CGH did not show any changes in DNA copy numbers. CONCLUSIONS The authors' study indicated that the two metastasizing PSTTs had balanced diploid karyotype. The malignant behavior of PSTTs may be not related to the DNA copy number changes. Such cytogenetic study may be useful in distinguishing metastatic PSTT from choriocarcinoma. Cancer 2002;94:2288–94. © 2002 American Cancer Society. DOI 10.1002/cncr.10424

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Prognostic Factors and Treatment for Placental Site Trophoblastic Tumor—Report of 3 Cases and Analysis of 88 Cases

Chang

Hsueh

et al. 1999

Gynecologic Oncology

110

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Metastasizing placental site trophoblastic tumor: Immunohistochemical and DNA analysis 2 case reports and a review of the literature

Cited by 13 publications

References 18 publications

The Pattern of Expression of Human Placental Lactogen Across Normal, Lactational, and Malignant Mammary Epithelium

The Pattern of Expression of Human Placental Lactogen Across Normal, Lactational, and Malignant Mammary Epithelium

Malignant placental site trophoblastic tumor

Prognostic Factors and Treatment for Placental Site Trophoblastic Tumor—Report of 3 Cases and Analysis of 88 Cases

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