Metastasizing fetal neuroblastoma with involvement of the placenta simulating fetal erythroblastosis

Anders, D.; Kindermann, G; Pfeifer, U

doi:10.1016/s0022-3476(73)80009-5

Cited by 51 publications

(11 citation statements)

References 5 publications

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“…Neuroblastoma is by far the most common malig nancy involving the placenta, with 15 cases (45.5%) reported [5][6][7]12,15,18,20,21,[24][25][26]. Placentomegaly and hydropic changes were cited in 12 of the (80%), but the remaining cases [7,20] did not include gross descriptions or specify placental weights (Table 1).…”

Section: Discussionmentioning

confidence: 99%

Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review

et al. 2014

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We report a case of a male newborn with trisomy 21 and transient abnormal myelopoiesis at birth whose placenta showed extravasated fetal blasts in the perivillous (maternal) space. Concern for possible maternal spread of fetal malignancy prompted a Kleihauer-Betke test and flow cytometric analysis of the maternal peripheral blood on postpartum day 2. Notably, no evidence of the persistence of fetal cells in the maternal blood was identified, a finding that likely reflected successful maternal immunologic clearance of the fetal blasts and erythrocytes, and/or blast cellular fragility and limited viability. Ours is the first report, to our knowledge, documenting maternal peripheral-blood follow-up evaluation of this disorder in the English literature. We discuss our case in the context of a comprehensive review of fetoneonatal solid tumor and leukemic proliferative disorders with placental involvement and evidence of maternal metastasis.

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Section: Discussionmentioning

confidence: 99%

Trisomy 21–Associated Transient Abnormal Myelopoiesis Involving the Maternal Space of the Placenta: A Case Report and Literature Review

et al. 2014

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“…Within this context, the possibility should be mentioned of tumour cells passing into the mother's circulation, although metastasis in the mother has never been observed. Metastasis into the placenta was also seen by Anders et al [25] in 2 cases, with both fetuses dying postnatally. Neither placental metastasis nor hydrops placentae were observed in the current cases.…”

Section: Metastasis/placental Lesionsmentioning

confidence: 60%

“…Hydrops placentae has also been observed [12,22,25]. Hydrops placentae combined with metastases in the placenta were seen by Strauss and Driscoll [26] in 2 cases.…”

Section: Metastasis/placental Lesionsmentioning

confidence: 99%

Prenatal Diagnosis of Congenital Neuroblastoma

et al. 1999

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Objective: Advances in prenatal diagnostics during the last 10 years have enabled the examiner to detect even rare fetal disorders such as fetal tumours. Congenital neuroblastoma is the most frequent solid neoplasm in infancy, with a retroperitoneal cystic or solid mass being a sonographic sign of the conditions. Methods: We present 4 cases of neuroblastoma showing suspicious prenatal ultrasound findings. The investigation comprises detection during pregnancy, typical sonographic signs, as well as the postnatal outcome. In addition, a review of the literature is undertaken with a focus on prenatal sonographic signs of congenital neuroblastomas. Results: In all 4 cases, a cystic tumour was detected during the 3rd trimester of pregnancy by means of B-mode sonography. One boy died of disseminated metastases at the age of 26 months. The other 3 survived after surgery and have remained healthy. Conclusions: The detection of a cystic suprarenal mass is suspicious of a congenital neuroblastoma. The delivery should take place at a perinatal centre.

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“…The merits of expressing the output of urinary metabolites on the basis of creatinine excretion as opposed to 24-hour collections has been debated (Vestergaard and Leverett, 1958;Cramer, Cramer, and Selander, 1967;Applegarth, Hardwick, and Ross, 1968;Gitlow et al, 1968). The convenience of the former approach cannot be denied, particularly where a complete collection of the specimen is difficult, as in young children (Gitlow et al, 1968).…”

Section: Discussionmentioning

confidence: 99%

“…It is thus important to try to define each condition biochemically by determining the normal excretion range of the phenolic acids disturbed in these and allied pathological conditions. It is similarly important to determine the normal range of cate-cholamine metabolite output so that any significant increase is readily detected: it may facilitate the rapid diagnosis of one of the most common neoplasms of early life, the catecholamine-secreting neuroblastoma (Brett et al, 1964;Anders, Kindermann, and Pfeifer, 1973).…”

mentioning

confidence: 99%