Metastasising liposarcoma of bone in a young dog

Frase, R; Freytag, Morton; Baumgartner, W. J.; Wohlsein, P.

doi:10.1136/vr.164.12.372

Cited by 10 publications

(13 citation statements)

References 10 publications

(19 reference statements)

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“…Liposarcomas have been further classified into subtypes based on cellular morphology, however the different histological appearances do not correspond to differences in biological behavior in domestic animals . Although liposarcomas generally show a low metastatic potential, they are characterized by local invasion and high recurrence rate …”

Section: Introductionmentioning

confidence: 99%

Comparisons Among Computed Tomographic Features of Adipose Masses in Dogs and Cats

Spoldi

Schwarz

Sabattini

et al. 2016

Vet Radiology Ultrasound

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A better understanding of the CT features of different forms of canine and feline adipose tumors would be valuable for improving patient management and treatment. The purpose of this retrospective, cross-sectional study was to describe and compare the CT features of pathologically confirmed lipomas, infiltrative lipomas, and liposarcomas in a sample of canine and feline patients. A total of 50 animals (46 dogs, four cats) and a total of 60 lesions (23 lipomas, 20 infiltrative lipomas, and 17 liposarcomas) were included in the study. Lipomas appeared as round to oval-shaped (n = 21), well-marginated (n = 20) fat-attenuating lesions. Infiltrative lipomas appeared as homogeneous, fat-attenuating masses but, unlike lipomas, they were most commonly characterized by an irregular shape (75%; P < 0.001), and linear components, hyperattenuating relative to the surrounding fat (100%; P < 0.05). Liposarcomas were represented exclusively by heterogeneous lesions with soft tissue attenuating components with a multinodular appearance (76.5%; P < 0.05). Regional lymphadenopathy (n = 10) and amorphous mineralization (n = 4) were also observed in association with liposarcomas. Computed tomography can provide useful information regarding disease location, extent, and involvement of the adjacent structures. Tumor definition and shape were the most useful parameters to differentiate between lipomas and infiltrative lipomas. The presence of a heterogeneous mass, with a multinodular soft tissue component and associated regional lymphadenopathy and mineralization, were features favoring a diagnosis of liposarcoma.

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Section: Introductionmentioning

confidence: 99%

Comparisons Among Computed Tomographic Features of Adipose Masses in Dogs and Cats

Spoldi

Schwarz

Sabattini

et al. 2016

Vet Radiology Ultrasound

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“…2 In dogs, liposarcoma is locally invasive neoplasms that rarely metastasize and occur primarily in appendicular or axial locations. 4 They have been described in various localizations such as the bone, 9 shoulder, thorax, axilla, tail, hip regions, and viscera. 10 The archives of a large ocular pathology laboratory showed fourteen eye liposarcomas diagnosed in dogs, thirteen showing an orbital localization and one originated in the third eyelid (Dubelzieg R, data of the COPLOW, personal communication).…”

Section: Discussionmentioning

confidence: 99%

A case of well‐differentiated palpebral liposarcoma in a Guinea pig (Cavia porcellus)

Quinton

Ollivier

Dally³

2013

Veterinary Ophthalmology

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Liposarcomas are rare malignant tumors of the adipose tissue which are well described in humans and animals. Wide margin excision is the recommended treatment for these infiltrative, slow to metastasize tumors. Primary liposarcoma with ocular localization is a very rare tumor in humans, dogs and cats. This report describes, for the first time, a palpebral liposarcoma in a 18-month old guinea pig that presented with a large palpebral mass and purulent discharge in the right eye. The ophthalmic evaluation revealed a one-centimeter infiltrating subcutaneous mass within the upper eyelid, a severe chemosis and hyperhemia of the palpebral and bulbar conjunctiva of the right eye. Cytologic examination of the mass revealed only epithelial cells. Histologic examination interpreted the lesion as a xanthogranulomatous reaction possibly secondary to meibomian gland rupture or inflammation. One month later, the mass had increased in size and the animal had stopped eating. Euthanasia was performed and a large biopsy was submitted for another histological examination. Histopathology revealed polygonal to rounded cells with a large, empty intracytoplasmic vacuole, and an ovoid, eccentrically located nucleus. The histology was consistent with a well-differentiated liposarcoma. Given the unusual location, immunohistochemistry was performed to ascertain the mesenchymal nature of the neoplasm.

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“…11 In dogs, metastases have been reported mainly in lung, spleen, liver, kidney, and lymph nodes. 3,17,38,65 Well-differentiated variant. Considered the most common histologic subtype, 31 well-differentiated variant consists of multilobular, fairly well-circumscribed but unencapsulated neoplasms that arise from the subcutis.…”

Section: Research-article2014mentioning

confidence: 99%

“…16,42 The histological staining reviewed in the literature of veterinary liposarcomas include oil red O, 7,9,12,14,16,18,29,30,45,46,49,52,66 periodic acid-Schiff, 1,34 osmium tetroxide, 18,45,52 alcian blue, and toluidine. 17,45 The immunohistochemical markers most frequently used were vimentin, 1,14,16,42,43,47,52,59,65 S100, 1,16,42,47,59,65 cytokeratin, 1,16,42,43,47,50,52,59,65 CD3, 51 actin, 14,51,65 and desmin. 42,<...>…”

Section: Research-article2014mentioning

confidence: 99%

Liposarcoma in animals

et al. 2015

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Liposarcomas are malignant tumors of adipocytes. The current report describes a liposarcoma in a 2.5-year-old, mixed-breed commercial sow that was detected during meat inspection. On gross examination, a firm, whitish, multinodular, 20 cm ×10 cm mass was observed in the perirenal area along with smaller nodules multifocally scattered within the renal parenchyma. Histological examination revealed an anaplastic sarcoma with clear intracytoplasmic lipidic vacuoles that were positive for Sudan black staining. Most of the cells were also positive for S100 and vimentin immunohistochemistry. Based on these results, a diagnosis of a perirenal liposarcoma was established. To the authors' knowledge, no previous reports of liposarcomas in pigs have been published. This report also includes a review of the literature published on animal liposarcomas.

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Metastasising liposarcoma of bone in a young dog

Cited by 10 publications

References 10 publications

Comparisons Among Computed Tomographic Features of Adipose Masses in Dogs and Cats

Comparisons Among Computed Tomographic Features of Adipose Masses in Dogs and Cats

A case of well‐differentiated palpebral liposarcoma in a Guinea pig (Cavia porcellus)

Liposarcoma in animals

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