Metastasis to the oral and maxillofacial region. A systematic review.

Labrador, Alberto Jose Peraza; Marín, Néstor Ricardo González; Valdez, Luciano Hermios Matos; Sanchez, Katman Bear Toledo; Zabarburu, Wil; Ibazetta, Karem Annelise Rodriguez; Garcia, Alejandra Elvia Ruiz; Cabezas, Dayana Mamani; Romero, Leonardo; Conte, Aldo Manzur; Wright, John M.

doi:10.1016/j.jormas.2021.12.009

Cited by 10 publications

(43 citation statements)

References 49 publications

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“…Other possibilities include oral granulomatosis with polynangiitis (wegener's) [14]; or a pyogenic granuloma [35]. Also, in adult patients' metastatic disease might be considered [1,42].…”

Section: Discussionmentioning

confidence: 99%

Ligneous Gingivitis: A Systematic Review

Labrador¹

2022

J Dent Oral Sci

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Objective: Ligneous gingivitis (LG) is an uncommon disease caused by plasminogen deficiency with fibrin deposition, which affects principally the conjunctiva of the eyes. A systemic review of reported cases and case series was undertaken to evaluate this disease. Methods: Searches of detailed databases were performed. The variables were demographics, treatment, follow-up, location, histopathological findings, symptoms and plasminogen test results. Results: 49 cases were identified; LG was most frequently seen in white females (68.4%). The average age was 20.0 years, for males 17.1 years and for females was 20.9 years. The main symptom was pain with (40.8%), followed by painless presentation with (20.4%). The most common sign was bleeding (32.3%). Clinically, both upper and lower gingiva where most commonly evident in 49% of the cases, followed by the lower gingiva only with (18.4%). The mean size was 2.7cm. The presence of concurrent ligneous conjunctivitis was (69.4%). The average for plasminogen activity test was 24.7mg/mL. The recurrence was 59.2% and the mean follow-up was 18.9 months. Conclusion: The diagnosis was difficult to establish, there is not standard treatment, and recurrence is common. For the oral clinician this disease needs to be addressed in the differential diagnosis of gingival oral lesions.

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“…Other possibilities include oral granulomatosis with polynangiitis (wegener's) [14]; or a pyogenic granuloma [35]. Also, in adult patients' metastatic disease might be considered [1,42].…”

Section: Discussionmentioning

confidence: 99%

Ligneous Gingivitis: A Systematic Review

Labrador¹

2022

J Dent Oral Sci

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“…17 In order of frequency, primary tumours of the following organs can be found in the mandible: lung, breast, kidney, thyroid, liver, lower extremity, prostate, melanoma, colon-rectal, and uterus. 18 Kirschnick et al put lung and breast cancer at the top of the list, followed by liver, thyroid, prostate, kidney and colon. 19 Metastases to the oral cavity may occur at any age but are most common during the fifth and sixth decades of life and the site of the primary tumour differs by gender.…”

Section: Introductionmentioning

confidence: 99%

“…19 Metastases to the oral cavity may occur at any age but are most common during the fifth and sixth decades of life and the site of the primary tumour differs by gender. [18][19][20] In men, the most common primary site is the lung, followed by the kidney, prostate, liver, melanoma, and bones of the lower extremity, whereas in women it is the breast, followed by lungs, kidney, thyroid, female genital organs, and colon-rectum. 18,20 Concerning clinical signs, a mass, tumour or swelling were the most common, showing a malefemale ratio of 2:1.…”

Section: Introductionmentioning

confidence: 99%

“…[18][19][20] In men, the most common primary site is the lung, followed by the kidney, prostate, liver, melanoma, and bones of the lower extremity, whereas in women it is the breast, followed by lungs, kidney, thyroid, female genital organs, and colon-rectum. 18,20 Concerning clinical signs, a mass, tumour or swelling were the most common, showing a malefemale ratio of 2:1. 18 Young patients from 6 months to 17 years were more likely to have metastatic sarcomas with a better survival time after 5 to 10 years compared with adults.…”

Section: Introductionmentioning

confidence: 99%

“…18,20 Concerning clinical signs, a mass, tumour or swelling were the most common, showing a malefemale ratio of 2:1. 18 Young patients from 6 months to 17 years were more likely to have metastatic sarcomas with a better survival time after 5 to 10 years compared with adults. 18 In this paper, a case of a pathological fracture of a mandibular condyle caused by lung cancer metastasis has been described, with citations from the latest and most updated literature reviews.…”

Section: Introductionmentioning

confidence: 99%

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Mandibular metastasis of pulmonary adenocarcinoma: How unexpected could it be?

et al. 2023

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ObjectiveMetastatic tumours of bone must be considered in all patients with unexplained bone pain and particularly in patients who present with a known cancer, localised pain at multiple sites, and radiographic findings suggestive of metastasis. The purpose of this report was to present a case of a pathological fracture of the mandible as a consequence of metastatic pulmonary adenocarcinoma.Materials and MethodsIn July 2018 a 68‐year‐old male patient was hospitalised because of pulmonary adenocarcinoma and attended our department for an oral maxillo‐facial evaluation. He complained of pain and swelling in the right temporomandibular region resulting in a reported functional limitation.An Orthopantomogram (OPG) demonstrated a right intracapsular condylar compound fracture associated with an osteolytic lesion at the condyle base with jagged margins. Subsequently, a CT scan with contrast of the maxillo‐facial complex and a fine‐needle aspiration of the lesion was performed.ResultsCT images showed the presence of a right mandibular condyle fracture associated with a large osteolytic lesion which confirmed the pathological nature of the fracture. Fine‐needle aspiration of the lesion confirmed its metastatic nature. It was not possible to proceed with a mandibular resection due to the critical clinical condition of the patient who died in September 2018.ConclusionLung cancer frequently produces lytic‐type metastasis, sometimes even in the jaw. In patients with an established diagnosis of lung cancer, any radiolucent lesion of the jaw or an unexplained painful symptomatology to the oro‐maxillo facial complex should be placed in differential diagnosis with metastasis of the primary tumour.

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