Metastasis subcutáneas en prepucio secundarias a adenocarcinoma de recto

Laca, Enique Añibarro; Pindado, Juan Carlos Pérez-Irezabal; Calle, Teresa Ibañez; Ibarguren, Roberto Llarena

doi:10.4321/s0004-06142006000700011

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Metastasis is unilateral in only 15% of cases, whereas the corpus spongiosum and glans penis (with skin ulcerative lesions) 71 are each involved in 10% of patients and the prepuce in approximately 5%. 27 , 92 , 99 Exclusive skin lesions are extremely rare according to the most frequent route of dissemination. The high incidence of bilateral involvement is due to the fact that the corpora cavernosa communicate freely through an incomplete midline septum.…”

Section: Discussionmentioning

confidence: 99%

A review of penile metastasis

et al. 2012

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Penile cancer as primary disease is relatively rare in developed countries. The penis is a rare site of metastases in spite of its rich vascularization. Approximately 500 cases have been reported in the literature; almost 70% of primary lesions are of pelvic origin (from genitourinary or recto-sigmoid primary tumors). We describe a case of penile metastasis from lung cancer. The rarity of the event prompted us to also explore related reviews and discuss the incidence, physiopathology, diagnosis and therapy of penile secondary cancer.

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Section: Discussionmentioning

confidence: 99%

A review of penile metastasis

et al. 2012

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Metastatic Tumors to the Penis

Chaux¹,

Amin

Cubilla³

et al. 2010

Int J Surg Pathol

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This study presents clinicopathologic and outcome features of 17 patients with metastatic tumor to the penis. Primary sites and histological types were as follows: 6 urothelial carcinomas of urinary bladder, 4 prostatic carcinomas (2 adenocarcinomas and 2 adenosquamous carcinomas), 2 colorectal adenocarcinomas, 2 pulmonary carcinomas (1 squamous cell carcinoma and 1 small cell carcinoma), 1 squamous cell carcinoma of base of the tongue, 1 cutaneous malignant melanoma, and 1 acute myeloid leukemia. Literature review revealed similar distribution of organ sites in 437 cases. Most of our tumors were metachronous. Interval between primary and penile metastasis ranged from 3 to 60 months (mean 16 months). Most of the patients presented with a penile mass. Priapism was observed in 4 patients. The shaft was the commonest anatomical site involved (12 cases). Tumor emboli were usually found in the erectile tissues (14 cases), mainly corpora cavernosa. A total of 14 patients died of disseminated disease. Time interval between primary tumor and penile metastasis ranged from 3 to 60 months (mean 19 months) and between diagnosis of penile metastasis and death ranged from 0.25 to 18 months (mean 6 months), significantly shorter (P = .0058). Patients presented a median survival of 18 months from primary treatment and 5 months after diagnosis of penile metastasis. None of the patients who died of disseminated cancer lived more than 18 months after pathological diagnosis. Clinical evidence of penile involvement in a patient with a known malignancy is an ominous sign and should alert the clinicians to the dismal prognosis.

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Prognosis of men with penile metastasis and malignant priapism: a systematic review

et al. 2017

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Introduction: Metastases to the penis are rare, but can have severe consequences. The aim of this study was to systematically review the literature in order to gain more information on the presentation and prognosis of this metastatic disease.We reviewed the literature relating to all case reports, series and reviews about penile metastasis, from 2003 to 2013, through a Medline search. We identified 63 articles and 69 patients.Metastases were located on the root (38.8%), the shaft (38.8%) or the glans (22.2%) of the penis. The diagnosis of penile metastasis was made after the primary cancer had been diagnosed. The most common presentation was a single small penile nodule. Ten patients reported priapism. The median survival time after diagnosis of penile metastasis was 10 months (range 6-18 months). A Kaplan-Meier analysis has shown that the patients presenting with priapism and those with metastases from non-urologic tumors have a significantly worse prognosis (age adjusted Log Rank: p=0.037 for priapism vs. no priapism and p=0.045 for urologic vs. non urologic).There are prognostic differences based on the presentation of penile metastases. Survival is substantial and treatment should therefore take into account symptoms improvement and quality of life.

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Metastasis subcutáneas en prepucio secundarias a adenocarcinoma de recto

Cited by 4 publications

References 3 publications

A review of penile metastasis

A review of penile metastasis

Metastatic Tumors to the Penis

Prognosis of men with penile metastasis and malignant priapism: a systematic review

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