Metastasis of lung adenocarcinoma to the jaw bone

Rajinikanth, M; Prakash, A Ravi; Swathi, T Rukmini; Reddy, S. Pooja Sri

doi:10.4103/0973-029x.174624

Cited by 9 publications

(3 citation statements)

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“…Unfortunately, oral metastases are usually evidence of a widespread disease and indicate a poor prognosis with reported survival time after oral metastases diagnosis of 3.7-8.25 months 2 .…”

Section: Discussionmentioning

confidence: 99%

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Jaw metastasis as first presentation of lung adenocarcinoma - a case report

Mateus

Oliveira

Santos³

et al. 2021

j.maxilo

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Section: Discussionmentioning

confidence: 99%

“…The metastatic disease in the oral cavity can manifest itself as tumefaction, pain, exophytic mass, paresthesia and numbness, toothache, dentoalveolar swelling, and loose teeth 2 .…”

Section: Introductionmentioning

confidence: 99%

Jaw metastasis as first presentation of lung adenocarcinoma - a case report

Mateus

Oliveira

Santos³

et al. 2021

j.maxilo

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“…It represents approximately 1–3% of all oral malignancies. Such metastases can occur to the bone or to the oral soft tissues [10]. Almost any malignancy from any site is capable of metastasis to the oral cavity even though the rate is quite low.…”

Section: Introductionmentioning

confidence: 99%

Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review

Abe¹,

Watanabe²,

Shinozaki‐Ushiku³

et al. 2019

BMC Cancer

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BackgroundCancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could improve accuracy of diagnosis of CUPs and might improve the prognosis of patients with CUPs.Case presentationA 76-year old male with an adenocarcinoma of unknown primary origin in the lung presented with another tumor of the palate mucosa. The tumor cells in the pleural effusion were all negative for immunohistochemical markers (TTF-1 and Napsin A) and lung-specific oncogenic driver alterations (EGFR mutation and ALK translocation). The tumor of the palate mucosa was likewise identified as an adenocarcinoma, and the cells showed cytological similarities with the tumor cells in the pleural effusion; TTF-1, Napsin A, EGFR mutation and ALK translocation were all negative. This result suggested that origins of the tumors of the palate mucosa and in the lung were the same, even though the origin had not yet been determined. Next, we addressed whether the tumor of the palate mucosa was a primary tumor or not. Secretory carcinoma (SC), which is a common type of minor salivary gland tumor (MSGT), was suspected; however, mammaglobin was negative and ETV6-NTRK3 (EN) fusion was not observed. Other MSGTs were excluded based on histological and immunohistochemical findings. Furthermore, an additional examination demonstrated an oncogenic KRAS mutation at codon 12 (p.G12D) in both palate tumor and in pleural effusion. KRAS mutation is known to exist in one-third of lung adenocarcinomas (LUADs), but quite rare in MSGTs. The possibility of metastasis from other organs was considered unlikely from the results of endoscopic and imaging studies. This result indicated that the primary site of the CUP was indeed the lung, and that the tumor of the palate mucosa was a metastasis of the LUAD.ConclusionsA tumor of the palate mucosa that showed diagnostic difficulties was determined to be a metastatic LUAD by genomic alterations and histopathological findings.Electronic supplementary materialThe online version of this article (10.1186/s12885-019-5277-1) contains supplementary material, which is available to authorized users.

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Malignant Tumors in Jaws

Larheim

Westesson

2017

Maxillofacial Imaging

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Metastasis of lung adenocarcinoma to the jaw bone

Cited by 9 publications

References 10 publications

Jaw metastasis as first presentation of lung adenocarcinoma - a case report

Jaw metastasis as first presentation of lung adenocarcinoma - a case report

Identification of a metastatic lung adenocarcinoma of the palate mucosa through genetic and histopathological analysis: a rare case report and literature review

Malignant Tumors in Jaws

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