Metastasis of Lobular Breast Carcinoma to the Uterus in a Patient under Anastrozole Therapy

Abstract

Background: Metastasis of extragenital neoplasms to the uterus are rarely encountered, and usually occur as a manifestation of advanced disease. Lobular carcinoma is the most common type of breast cancer that metastasizes to the uterus. Case Report: We report on a 56-yearold woman who 3 years previously was diagnosed with invasive lobular carcinoma of the breast and was treated with surgery followed by chemotherapy and radiotherapy. While the patient was on adjuvant anastrozole therapy for 2 years, she complained of vaginal bleeding. Because of endometrial thickening and a uterine leiomyoma detected during abdominal ultrasonographic ex-amination, a total hysterectomy with bilateral salpingooophorectomy was performed. Histopathologic examination of the specimens revealed carcinoma infiltration of the myometrium, endometrium, cervix, uterine tube, and left ovary. Immunohistochemical staining of tumoral cells with pancytokeratin and gross cystic disease fluid protein (GCDFP-15) proved the diagnosis of metastatic lobular breast carcinoma to the uterus. Conclusion: To our knowledge, this is the second case of lobular breast carcinoma metastasized to the uterus under anastrozole therapy. In women with lobular breast cancer under adjuvant anastrozole therapy, who present with vaginal bleeding, uterine metastasis of lobular carcinoma should be considered in the differential diagnosis.

Adenocarcinoma metastatic to the uterine cervix: A case series

“…Finally, we excluded any references that were not available in complete text form or lacked the data we required for this analysis (Table 2). For the purposes of our review, we included 13/16 (81.2%) publications associated with gastric cancer, 14–28 30/45 (66.6%) with breast cancer, 14,18,21,29–55 9/13 (69.2%) with ovarian cancer, 15,18,21,29,56–60 and 10/13 reports (76.9%) related to colorectal cancer 15,18,19,21,61–66 . The total number of patients covered in these reports was 45 for gastric cancer, 36 for breast cancer, 36 for ovarian cancer and 19 for colorectal cancer.…”

Isolated Uterine Metastasis of Invasive Ductal Carcinoma

“…IDC accounts for approximately 70–75% of all breast cancers compared to ILC that only accounts for 5–20%. Despite of its lower incidence in all breast cancers, ILC is the most frequent histologic type that metastasizes to the female genital tract in more than 80% of all cases [6]. Nevertheless, it should be kept in mind that IDC also may metastasize to the gynecologic organs alone, as seen in our case.…”

“…But interestingly, as seen in our case, uterine metastases may grow in patients receiving anastrozole therapy. A few number of reports regarding gynecologic metastases from breast cancer under anastrozole treatment were published [6, 11]. When the interesting feature of isolated uterine metastasis under anastrozole therapy was taken, comments can be made according to histologic type of primary breast lesion.…”

Endometrial and cervical metastases leading to the diagnosis of a primary breast cancer: A case report

“…When compared both types of cancer show very different rates of occurrence with IDC appearing in 70-75% of the breast cancer cases and ILC with much lower rates of 5-20%. Regardless of its low rates shown in the cases, ILC occurs most often compared to other histological types which metastasise to the female genital tract, constituting more than 80% of all known occurrences [10]. Compared to their rate of occurrence the metastasis appear most commonly in the ovaries -75.8% of the cases, and showing less frequently in the vagina -13.4% of the cases, followed by the uterine corpus with 4.7%, cervix -3.4%, vulva -2% and fallopian tubes -0.7% of the known cases [7].…”