Metastasis of Breast Cancer to the Appendix Causing Acute Appendicitis

Iwamoto, Naoko; Suzuki, Takahisa; Tsukada, Kenji; Kunii, Y; Haraguchi, Yoshiaki; Orihata, Michihiro; Kobayashi, Shigeru; Yamasaki, Shigetaka

doi:10.14789/jmj.60.349

Cited by 2 publications

(5 citation statements)

References 13 publications

(13 reference statements)

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“…More studies are needed to explore targeted treatment to achieve better outcomes in this patient population. Although metastases to the appendix causing acute appendicitis are rare in clinical practice, this should be considered as part of the differential diagnosis when a cancer patient presents with suggestive symptoms [2]. Special attention should be given to differentiate primary and metastatic ovarian tumors in breast cancer patients, often requiring immunohistochemical studies for this precise diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…It is well known that metastases induced by breast cancer are most commonly in the lungs, bones and liver. However, metastases of the appendix are extremely rare and acute appendicitis induced by a metastatic tumor is also uncommon [2]. Ovarian metastases is more common than the metastases of the appendix.…”

Section: Introductionmentioning

confidence: 99%

“…In a review it was reported that incidental appendiceal tumor detected after appendectomy accounts for only 0.9 % of cases (74/7990), and among them, metastatic tumor was only found in 11 cases [5], showing how extremely rare appendicular metastases cases are. The primary origins of metastatic appendix tumors are the breast, lung, stomach and colon [2]. The interval between the diagnosis of a primary cancer and the onset of appendicitis has varied from zero to six years [2,6].…”

Section: Introductionmentioning

confidence: 99%

“…The primary origins of metastatic appendix tumors are the breast, lung, stomach and colon [2]. The interval between the diagnosis of a primary cancer and the onset of appendicitis has varied from zero to six years [2,6]. There are few data in the literature reporting the appearance of appendiceal metastases as the initial manifestation of primary neoplasia.…”

Section: Introductionmentioning

confidence: 99%

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Metastases of breast cancer causing acute appendicitis: A case report

Jl¹,

Bsm²,

Mcdv³

et al. 2018

Cancer Rep Rev

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Background: Breast cancer (BC) is the most common type of cancer among women worldwide and advanced diagnosis is not uncommon. There are few data in the literature reporting the appearance of appendiceal and ovary metastases as the initial manifestation of primary neoplasia.Objective: increase the knowledge about possible clinical presentations of BC with metastasis in the appendix and ovary and to discuss possible ways to prevent worse evolutions of the metastases under discussion.Methods: This is a case report is a retrospective analysis of periodic consultations through the collection of data from the medical records obtained in the Liga Norte-Riograndense Contra Câncer -Natal-RN (Brazil) of the patient under study between January 2014 to May 2018. Case presentation:A 37-year-old woman presented abdominal pain with a mass in her right breast, near the areola, in addition there was a swollen lymph node in the right axilla and large pelvic mass. Given the severe abdominal pain, she was submitted to emergency exploratory laparotomy and in the intraoperative period were found inflammatory process characterized as acute appendicitis with blocked abscess, in addition to left ovary enlargement. During the investigation we discovered appendiceal and ovary metastases as the initial manifestation of BC. Conclusion:We report a relatively rare case of appendiceal and ovary metastases as the initial manifestation of BC with 52 months of no signs of illness. Although more studies are needed to explore targeted treatment to achieve better outcomes in this patient population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metastases of breast cancer causing acute appendicitis: A case report

Jl¹,

Bsm²,

Mcdv³

et al. 2018

Cancer Rep Rev

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“…Seventeen cases [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] of metastatic breast cancer causing appendicitis were identified. The age of the patients ranged from 35 up to 90 years old, with an average age of 54 years old.…”

Section: Breastmentioning

confidence: 99%

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

2023

J Surg

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Background: Acute appendicitis is one of the most common causes of acute abdomen presentation to the emergency department. Appendicectomy is one of the most common emergency operations performed. Appendicitis is attributed to lymphoid hyperplasia or faecolith causing obstruction of the appendiceal lumen. Other causes include helminth infection, primary appendiceal tumours, malignancy, and calculi. Metastatic malignancy causing acute appendicitis is very uncommon. In this article, we review the literature that exists reporting acute appendicitis attributed to metastatic diseases of the appendix, the malignancies that were identified, and the nature of the presentation. Methods:This study was performed following the Scale for the Assessment of Narrative Review Articles (SANRA). A literature review of existing case reports, abstracts, and studies was performed. PubMed and Google Scholar were used to search for the articles. Several cases were identified using the 'snowball method' where references were used to identify additional published literature.Results: Seventy-eight cases of acute appendicitis secondary to metastatic malignancies were identified. The most commonly reported metastatic malignancy causing appendicitis were breast, lung, gastric, and prostate. There was a total of n=34 (46%) of individuals with complicated appendicitis, n=40 (54%) with uncomplicated appendicitis, and four cases did not have degree of inflammation documented. The mean age of the patients was 57 years old. Conclusion:Appendicitis secondary to metastatic disease is a rare entity. This literature review has collated data identifying known primary malignancies that are associated with metastatic disease to the appendix. The most common have been identified as breast, lung, gastric and prostate primary malignancies. The mean age of patients in this review is 57. Patients presented with more complicated disease in comparison to the general population with acute appendicitis without malignancy. While rare, it important to be cognizant to the patient's previous malignancies even after the surveillance period has been completed. In this article we review the literature that exists reporting acute appendicitis attributed to secondary metastatic disease of the appendix, the malignancies that were identified and the nature of the presentation. When considering management of appendicitis, it is important to be cognizant as to whether the patient has had previous malignancies even after the surveillance period is over.

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Metastasis of Breast Cancer to the Appendix Causing Acute Appendicitis

Cited by 2 publications

References 13 publications

Metastases of breast cancer causing acute appendicitis: A case report

Metastases of breast cancer causing acute appendicitis: A case report

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

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