Metastases of breast cancer causing acute appendicitis: A case report

Jl, Araujo; Bsm, Cavalcanti; Mcdv, Soares; Uw, Sousa; Gpd, Medeiros

doi:10.15761/crr.1000155

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…Seventeen cases [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] of metastatic breast cancer causing appendicitis were identified. The age of the patients ranged from 35 up to 90 years old, with an average age of 54 years old.…”

Section: Breastmentioning

confidence: 99%

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

2023

J Surg

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Background: Acute appendicitis is one of the most common causes of acute abdomen presentation to the emergency department. Appendicectomy is one of the most common emergency operations performed. Appendicitis is attributed to lymphoid hyperplasia or faecolith causing obstruction of the appendiceal lumen. Other causes include helminth infection, primary appendiceal tumours, malignancy, and calculi. Metastatic malignancy causing acute appendicitis is very uncommon. In this article, we review the literature that exists reporting acute appendicitis attributed to metastatic diseases of the appendix, the malignancies that were identified, and the nature of the presentation. Methods:This study was performed following the Scale for the Assessment of Narrative Review Articles (SANRA). A literature review of existing case reports, abstracts, and studies was performed. PubMed and Google Scholar were used to search for the articles. Several cases were identified using the 'snowball method' where references were used to identify additional published literature.Results: Seventy-eight cases of acute appendicitis secondary to metastatic malignancies were identified. The most commonly reported metastatic malignancy causing appendicitis were breast, lung, gastric, and prostate. There was a total of n=34 (46%) of individuals with complicated appendicitis, n=40 (54%) with uncomplicated appendicitis, and four cases did not have degree of inflammation documented. The mean age of the patients was 57 years old. Conclusion:Appendicitis secondary to metastatic disease is a rare entity. This literature review has collated data identifying known primary malignancies that are associated with metastatic disease to the appendix. The most common have been identified as breast, lung, gastric and prostate primary malignancies. The mean age of patients in this review is 57. Patients presented with more complicated disease in comparison to the general population with acute appendicitis without malignancy. While rare, it important to be cognizant to the patient's previous malignancies even after the surveillance period has been completed. In this article we review the literature that exists reporting acute appendicitis attributed to secondary metastatic disease of the appendix, the malignancies that were identified and the nature of the presentation. When considering management of appendicitis, it is important to be cognizant as to whether the patient has had previous malignancies even after the surveillance period is over.

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Section: Breastmentioning

confidence: 99%

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

2023

J Surg

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“…Shelat et al [14] 59, F Invasive ductal carcinoma with positive ER, PR, and HER2 receptors Radiotherapy and chemotherapy of the right hemicolectomy, followed by RM and adjuvant chemotherapy Araujo et al [15] 37, F The ductal organ is affected by cancers of ER, PR, and HER2 (positive for any of these markers)…”

Section: Surgical Removal Of the Ileocecal And Appendixmentioning

confidence: 99%

Multiple bone metastases in advanced breast cancer: a gastrointestinal surgical emergency

Wang#

Lin

et al. 2023

Preprint

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Patient: Female, 33-year-old Final Diagnosis: Advanced breast cancer with bone metastasis Symptoms: Acute Abdominal pain Clinical Procedure: — Specialty: General Surgery • Oncology Objective: Unusual clinical course Background: Globally, acute abdominal pain is a common reason for admission to emergency departments. As with fever, it can be difficult to identify the cause. Metastatic breast cancer, which usually spreads to the lungs, brain, liver, and bones, is living longer among patients. Metastasis may present complications that were not previously seen due to improved survival rates. Patients with advanced metastatic breast cancer who experience sudden acute abdominal pain are at risk for this rare complication. Case Report: In an emergency department of gastrointestinal surgery, a 33-year-old female presented with sudden acute abdominal pain for no apparent reason. It was highly suspected that the patient had acute appendicitis based on his history and physical examination. CT scans of the chest and abdomen in the emergency department revealed bilateral breast cancer with multiple bone metastases (lumbar spine, iliac crest). Emergency abdominal exploration was performed after the patient's abdominal pain aggravated. In the patient's abdomen, extensive metastasis and cancerous adhesions were discovered, and the prognosis was extremely poor. It was not possible to explore the appendix and intestines further, so abdominal irrigation, abscess drainage, and abdomen closure were performed. Upon recovery from surgery, the patient was transferred to the Department of Breast and Thyroid Surgery for chemotherapy. A first course of doxorubicin liposome + cyclophosphamide chemotherapy was followed by a second course of albumin + paclitaxel chemotherapy. During the first course of treatment, a CT examination revealed new lumbar metastases and a reduction of the right breast mass. We are now in the process of further treatment and follow-up observation. Conclusions: A clinician should consider metastatic breast cancer pain when treating a female patient with acute abdominal pain. It is possible to die from acute abdominal pain, which has a wide range of causes. When breast cancer is not detected early, it can also occur repeatedly with various other clinical manifestations in the later stages.

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“…Management strategies varied widely, ranging from a simple appendectomy to a more extensive right hemicolectomy [11]. The primary origins of these metastatic appendiceal tumors included breast, lung, stomach, and colon, and the interval between primary cancer diagnosis and appendicitis onset ranged from immediate to as long as 6 years [12].…”

Section: Metastatic Involvement Of the Appendix: A Rare Occurrencementioning

confidence: 99%

Metastatic Breast Cancer Presenting as Acute Appendicitis: A Rare Case Study and Review of Current Knowledge

Markovic,

Stojanovic,

Jovanovic

et al. 2023

Diagnostics

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This manuscript discusses a rare case of acute appendicitis caused by metastasis from invasive breast carcinoma of no special type in a 70-year-old female previously diagnosed with breast cancer. It delves into the diagnostic challenges and management complexities of such unusual clinical presentations. The paper includes an analysis of 19 documented cases, enriching the understanding of metastatic patterns and treatment strategies in breast cancer. It underlines the importance of considering a history of malignancy when diagnosing acute abdominal conditions and emphasizes a comprehensive approach in interpreting diagnostic imaging in patients with past oncological issues to effectively manage metastatic breast cancer exhibiting atypical manifestations.

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Metastases of breast cancer causing acute appendicitis: A case report

Cited by 6 publications

References 7 publications

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

Acute Appendicitis Secondary to Metastatic Malignancy - A Review of 78 Cases in Literature

Multiple bone metastases in advanced breast cancer: a gastrointestinal surgical emergency

Metastatic Breast Cancer Presenting as Acute Appendicitis: A Rare Case Study and Review of Current Knowledge

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