Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp

Açıkalın, Mustafa Fuat; Öner, Ülkü; Tekin, Başar; Yavuz, Ekrem; Cengiz, Osman

doi:10.1016/j.ygyno.2005.03.019

Cited by 20 publications

(19 citation statements)

References 12 publications

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“…Although metastasis of lobular breastcarcinomatreatedwithtamoxifentotheendometrium has been described, breast cancer metastasis to the uterus underadjuvantanastrozoletherapyisuncommonwithonly1 casereportintheEnglishmedicalliterature [8].Inourcase, wethinkthatmetastasisfrombreastcancertotheuteruswas presentunrelatedtotheendocrineeffectsofanastrozoletherapyontheuterus.…”

Section: Discussionmentioning

confidence: 79%

“…Metastasisofextragenitalneoplasmstothegenitaltractisuncommon and mainly affects the ovaries and the vagina, but rarelytheuterusasinourcase [3,6,8,13].Breastcanceris the most common extragenital cancer to metastasize to the uterus,witharateof47% [2,8,14].Invasivelobularcarcinomaofthebreastisresponsibleformorethan80%ofmetas-tasesingynecologicorgans,muchmorethaninvasiveductal carcinoma.Inourcasealso,thepatienthadinvasivelobular carcinoma [3,6,15,16].…”

Section: Discussionmentioning

confidence: 99%

“…Histology alone cannot usually provideadefinitivediagnosis,andimmunohistochemicalstaining isrequired [2,8].GCDFP-15isahighlyspecificandsensitive markertoconfirmprimarybreastoriginofmetastatictumors [2,20]. Mazoujian et al [21] and Perisic et al [15] reported that 55% of breast cancer stained positively for GCDFP-15, and90%ofthemwerefoundtobeinvasivelobularcarcinoma withsignetcelldifferentiation.Thehistologyinourcasewas alsoinvasivelobularcarcinomawithsignetcelldifferentiation.…”

Section: Discussionmentioning

confidence: 99%

“…Metastasis from extragenital sites to the uterus is found in only 10% of patients, and the uterine corpus is mostly affected [1][2][3].Breastandgastrointestinaltumorsarethemost common extragenital tumors metastasizing to the uterus [1,4,5].Uterinemetastasisofbreastcancerhasbeenpreviously reported [6][7][8]tooccurin2-15%ofpatients,andlobularcarcinomaisthemostcommonhistopathologictypetometastasizetotheuterus [9].…”

Section: Introductionmentioning

confidence: 99%

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Metastasis of Lobular Breast Carcinoma to the Uterus in a Patient under Anastrozole Therapy

Ustaalioglu¹,

Bılıcı²,

Şeker³

et al. 2009

Onkologie

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Background: Metastasis of extragenital neoplasms to the uterus are rarely encountered, and usually occur as a manifestation of advanced disease. Lobular carcinoma is the most common type of breast cancer that metastasizes to the uterus. Case Report: We report on a 56-yearold woman who 3 years previously was diagnosed with invasive lobular carcinoma of the breast and was treated with surgery followed by chemotherapy and radiotherapy. While the patient was on adjuvant anastrozole therapy for 2 years, she complained of vaginal bleeding. Because of endometrial thickening and a uterine leiomyoma detected during abdominal ultrasonographic ex-amination, a total hysterectomy with bilateral salpingooophorectomy was performed. Histopathologic examination of the specimens revealed carcinoma infiltration of the myometrium, endometrium, cervix, uterine tube, and left ovary. Immunohistochemical staining of tumoral cells with pancytokeratin and gross cystic disease fluid protein (GCDFP-15) proved the diagnosis of metastatic lobular breast carcinoma to the uterus. Conclusion: To our knowledge, this is the second case of lobular breast carcinoma metastasized to the uterus under anastrozole therapy. In women with lobular breast cancer under adjuvant anastrozole therapy, who present with vaginal bleeding, uterine metastasis of lobular carcinoma should be considered in the differential diagnosis.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Metastasis of Lobular Breast Carcinoma to the Uterus in a Patient under Anastrozole Therapy

Ustaalioglu¹,

Bılıcı²,

Şeker³

et al. 2009

Onkologie

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“…To our knowledge, there are only 11 cases in the literature of endometrial polyp involvement by a metastatic neoplasia: one case of cutaneous melanoma [3] and breast cancer in the others [4][5][6][7][8][9][10][11][12]. Of these latter, seven patients were reported to be receiving adjuvant endocrine treatment with tamoxifene at the time of the diagnosis [6,[8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Metastatic breast ductal carcinoma detected in a toremifene-associated endometrial polyp: case report and literature review

et al. 2009

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Uterine metastases are rare events, but when they occur, the first extragenital neoplasm responsible is breast carcinoma. Toremifene, used in breast cancer hormonotherapy, has a partial estrogenic agonist effect in the endometrium, responsible for potential abnormalities, like polyps. A 53-yearold woman, receiving toremifene due to previously excised breast ductal carcinoma, presented with endometrial thickness during an abdominopelvic ultrasound follow-up. Hysteroscopy revealed an endometrial polyp, which was removed. Microscopic examination showed infiltration by a malignant ductal pattern neoplasm, with signet ring cells. The patient underwent hysterectomy and bilateral salpingo-oophorectomy. The final pathological diagnosis was metastatic breast carcinoma to the endometrium and cervix. This is the first reported case of breast metastases detected in a toremifene-associated endometrial polyp.

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The potential role of HER2 upregulation in metastatic breast cancer to the uterus: a case report

Moey¹,

Hassan²,

Papageorgiou

et al. 2016

Clinical Case Reports

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Key Clinical MessageAbnormal uterine bleeding in a patient on maintenance hormonal therapy for breast cancer should raise concern for endometrial abnormalities including rare uterine metastasis from the breast. Hormonal receptor profile changes in metastatic lesions favoring human epidermal growth factor receptor 2 (HER2) overexpression may be involved in the pathogenesis of metastasis to the uterus.

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Metastasis from breast carcinoma to a tamoxifen-related endometrial polyp

Cited by 20 publications

References 12 publications

Metastasis of Lobular Breast Carcinoma to the Uterus in a Patient under Anastrozole Therapy

Metastasis of Lobular Breast Carcinoma to the Uterus in a Patient under Anastrozole Therapy

Metastatic breast ductal carcinoma detected in a toremifene-associated endometrial polyp: case report and literature review

The potential role of HER2 upregulation in metastatic breast cancer to the uterus: a case report

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