Metastasis and MAPK Pathways

Kciuk, Mateusz; Gielecińska, Adrianna; Budzinska, Adrianna; Mojzych, Mariusz; Kontek, Renata

doi:10.3390/ijms23073847

Cited by 67 publications

(35 citation statements)

References 243 publications

(301 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly, the RELA proto-oncogene encodes a transcriptionally active subunit of the NF-kB complex that is strongly associated with PNST, but not FS or PWT DEGs ( Fig 5 ) and is being investigated as a therapeutic target [ 91 ]. The Ras-related protein gene RAP1A was also one of the most significantly expressed genes specific to PWTs ( Table 1 ) and Rap1A promotes cell migration and metastasis [ 92 , 93 ]. Inhibitors of factors mediating its activation have been examined for use as anti-cancer agents [ 94 ].…”

Section: Discussionmentioning

confidence: 99%

Comparative whole transcriptome analysis of gene expression in three canine soft tissue sarcoma types

et al. 2022

View full text Add to dashboard Cite

Soft tissue sarcomas are pleiotropic tumors of mesenchymal cell origin. These tumors are rare in humans but common in veterinary practice, where they comprise up to 15% of canine skin and subcutaneous cancers. Because they present similar morphologies, primary sites, and growth characteristics, they are treated similarly, generally by surgical resection followed by radiation therapy. Previous studies have examined a variety of genetic changes as potential drivers of tumorigenesis and progression in soft tissue sarcomas as well as their use as markers for soft tissue sarcoma subtypes. However, few studies employing next generation sequencing approaches have been published. Here, we have examined gene expression patterns in canine soft tissue sarcomas using RNA-seq analysis of samples obtained from archived formalin-fixed and paraffin-embedded tumors. We provide a computational framework for using resulting data to categorize tumors, perform cross species comparisons and identify genetic changes associated with tumorigenesis. Functional overrepresentation analysis of differentially expressed genes further implicate both common and tumor-type specific transcription factors as potential mediators of tumorigenesis and aggression. Implications for tumor-type specific therapies are discussed. Our results illustrate the potential utility of this approach for the discovery of new therapeutic approaches to the management of canine soft tissue sarcomas and support the view that both common and tumor-type specific mechanisms drive the development of these tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative whole transcriptome analysis of gene expression in three canine soft tissue sarcoma types

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The most recent studies focused on the effects of the MAPK pathway on tumor development [ 7 , 10 , 13 , 17 ]. Recently published research work showed that the MAPK pathway not only regulates the behavior of tumor cells, but also the behavior of surrounding normal stromal cells in the TME (tumor microenvironment) during cancer pathogenesis [ 7 ]. The specific activities of the MAPK pathway components in tumor initiation and progression vary based on the stimuli and stromal cells involved in tumor growth [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently published research work showed that the MAPK pathway not only regulates the behavior of tumor cells, but also the behavior of surrounding normal stromal cells in the TME (tumor microenvironment) during cancer pathogenesis [ 7 ]. The specific activities of the MAPK pathway components in tumor initiation and progression vary based on the stimuli and stromal cells involved in tumor growth [ 7 ]. Furthermore, the research about the effect of hypoxia on cancer cells showed that hypoxia-inducible transcription factor α (HIF1α) affects as a transcription factor many genes involved in anaerobic metabolisms, angiogenesis, and metastasis [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…The specific activities of the MAPK pathway components in tumor initiation and progression vary based on the stimuli and stromal cells involved in tumor growth [ 7 ]. Furthermore, the research about the effect of hypoxia on cancer cells showed that hypoxia-inducible transcription factor α (HIF1α) affects as a transcription factor many genes involved in anaerobic metabolisms, angiogenesis, and metastasis [ 7 ]. In addition, one recent report demonstrates that in certain conditions, the MAPK signaling pathway may regulate HIF activity, in part, by affecting the levels of HIF1α [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, IH and its biological effects have not yet been fully understood. Whereas some research claims that IH contributes to pathologic medical conditions [ 4 , 5 , 6 ], other research focuses on its curative properties [ 4 , 5 , 7 , 8 ]. Repeated episodes of hypoxia interspersed with normoxic intervals are the key components of IH [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Intermittent Hypoxia on the Attenuation of Induced Nasal Allergy and Allergic Asthma by MAPK Signaling Pathway Downregulation in a Mice Animal Model

Sultonov

Kim²,

Park

et al. 2022

IJMS

View full text Add to dashboard Cite

Intermittent hypoxia (IH) has been an issue of considerable research in recent years and triggers a bewildering array of both detrimental and beneficial effects in several physiological systems. However, the mechanisms leading to the effect are not yet clear. Consequently, we investigated the effects of IH on allergen-induced allergic asthma via the mitogen-activated protein kinase (MAPK) signaling pathway. Forty BALB/c mice were dived into four groups. We evaluated the influence of IH on the cell signaling system of the airway during the allergen-induced challenge in an animal model, especially through the MAPK (mitogen-activated protein kinase) pathway. The protein concentrations of p-ERK/ERK, p-JNK/JNK, p-p38/p38, and pMEK/MEK were significantly reduced in the allergen-induced+IH group, compared to the allergen-induced group (p-value < 0.05 as considered statistically significant). The number of eosinophils, neutrophils, macrophages, and lymphocytes in the bronchoalveolar lavage fluid and Dp (Dermatophagoides pteronyssinus)-specific IgG2a and interleukins 4, 5, 13, and 17 were significantly reduced in the Dp+IH group, compared to the Dp group. These findings suggest that the MAPK pathway might be associated with the beneficial effect of IH on the attenuation of allergic response in an allergen-induced mouse model.

show abstract

Updated aspects of alpha‐Solanine as a potential anticancer agent: Mechanistic insights and future directions

Nandi,

Sikder,

Nag

et al. 2024

Food Science & Nutrition

View full text Add to dashboard Cite

Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements in diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success in yielding effective treatments. This review focuses on α‐solanine, a glycoalkaloid primarily derived from potato tubers and nightshade family plants, recognized for its diverse biological activities, including anti‐allergic, antipyretic, anti‐inflammatory, anti‐diabetic, and antibiotic properties. Recently, α‐solanine has gained attention as a potential anticancer agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web of Science, Scopus, the American Chemical Society, Google Scholar, Springer Link, Wiley, and various commercial websites, this review consolidates two decades of research on α‐solanine's anticancer effects and mechanisms against nine different cancers, highlighting its role in modulating various signaling pathways. It also discusses α‐solanine's potential as a lead compound in cancer therapy. The abundant availability of potato peel, often discarded as waste or sold cheaply, is suggested as a sustainable source for large‐scale α‐solanine extraction. The study concludes that α‐solanine holds promise as a standalone or adjunctive cancer treatment. However, further research is necessary to optimize this lead compound and mitigate its toxicity through various strategies.

show abstract

Metastasis and MAPK Pathways

Cited by 67 publications

References 243 publications

Comparative whole transcriptome analysis of gene expression in three canine soft tissue sarcoma types

Comparative whole transcriptome analysis of gene expression in three canine soft tissue sarcoma types

Intermittent Hypoxia on the Attenuation of Induced Nasal Allergy and Allergic Asthma by MAPK Signaling Pathway Downregulation in a Mice Animal Model

Updated aspects of alpha‐Solanine as a potential anticancer agent: Mechanistic insights and future directions

Contact Info

Product

Resources

About