Metastases to breast simulating ductal carcinoma in situ: Report of two cases and review of the literature

Gupta, Deepali; Mj, Merino; Farhood, Anwar; Middleton, Lavinia P.

doi:10.1053/adpa.2001.21476

Cited by 42 publications

(24 citation statements)

References 17 publications

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“…Among 9 patients who did not take the core biopsy, 4 patients were diagnosed by fine needle aspiration (FNA) and the rest by excisional biopsy (Table III). Some authors have suggested that fine needle aspiration of the breast is the best approach to tumor diagnosis, and offers the most appropriate and as well as cost-effective patient management [21,27,28]. According Smymiotisto et al [23], preoperative FNA is invaluable because most cases in their report were indistinguishable from primary breast cancer by FNA findings.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of metastasis in the breast from extramammary malignancies

Lee

Kim

et al. 2010

Journal of Surgical Oncology

125

133

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Pathologic examination and considering known clinical history may be helpful to differentiate the primary breast cancer and metastatic cancer. Metastasis to the breast from an extramammary neoplasm usually indicates disseminated metastatic disease and a poor prognosis. An accurate diagnosis of breast metastases, differentiating primary from metastatic breast carcinoma, is important for proper management.

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Section: Discussionmentioning

confidence: 99%

Characteristics of metastasis in the breast from extramammary malignancies

Lee

Kim

et al. 2010

Journal of Surgical Oncology

125

133

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“…The majority (25 reports) described unilateral breast tumors. However, bilateral (four reports) [8], inflammatory (six reports) [9], and ductal carcinoma in situ-like (one report) [10] metastatic breast tumors were also described. Karam et al reported 10 cases of metastatic breast tumor and noted that the mean interval between the diagnosis of ovarian cancer and breast/axilla events was 70.7 months and that the median overall survival after a breast event was 26 months, suggesting that metastatic breast tumors from ovarian cancer are not associated with a poor prognosis [11].…”

Section: Discussionmentioning

confidence: 99%

The diagnosis of a metastatic breast tumor from ovarian cancer by the succession of a p53 mutation: a case report

et al. 2017

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BackgroundMetastatic breast tumors from other organs are very rare. We herein describe the case of a patient with a metastatic breast tumor due to ovarian cancer who was diagnosed by the succession of a p53 mutation.Case presentationThe patient was a 59-year-old woman with sigmoid colon stenosis. Diagnostic imaging revealed a pelvic mass, multiple liver tumors, ascites, and multiple swollen para-aortic lymph nodes, suggesting an advanced ovarian tumor. Transverse loop colostomy and partial resection of the greater omentum was performed followed by six cycles of paclitaxel with carboplatin chemotherapy (TC therapy). Her cancer almost disappeared, with the exception of a small tumor in her pelvis. Simple hysterectomy with bilateral salpingo-oophorectomy was performed. Two years and 5 months after the second surgery, a mass was detected in her right breast and simple mastectomy was performed. A histological examination of the tumors from the first surgery revealed infiltrating papillary adenocarcinoma and the solid nest proliferation of atypical cells with comedo necrosis and psammoma bodies. The findings of an immunohistochemical analysis were as follows: cancer antigen 125 (CA125 (+)), cytokeratin 7 (CK7 (+)), cytokeratin 20 (CK20 (−)), p53 (+) and CDX2 (−), estrogen receptor (ER (slightly +)), progesterone receptor (PR (slightly +)), and human epidermal growth factor receptor 2 (HER2 (1+)). The breast tumors presented similar morphological features (ER (−), PR (−), HER2 (−), CA125 (+), CK7 (+), CK20 (−), p53 (+), mammaglobin (−), and GCDFP15 (−)), which were not characteristic of breast cancer. A direct sequencing analysis of p53 revealed a p.V173M mutation in exon 5 in both the breast tumor and the ovarian cancer. It was not detected in normal tissue, suggesting that the breast tumors were metastatic serous adenocarcinomas from ovarian cancer.ConclusionsA direct sequencing mutation analysis of p53 was useful for distinguishing the primary tumor from the metastatic tumor. We should resect metastatic breast tumors to the extent that is possible because the prognosis of such patients is relatively good.

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“…2 On ultrasound, a metastasis from a nonmammary malignancy is typically hypoechoic, oval or round in shape, with microlobulated or circumscribed margins, and with posterior acoustic enhancement. 2 The exclusive use of FNAC for tumor diagnosis is disputed: several authors consider FNAC to be the best approach to tumor diagnosis, [3][4][5] whereas others believe FNA findings insufficient to distinguish metastases from primary breast cancer. 6 The medical history often helps the pathologist diagnose a metastatic disease to the breast only with FNAC, but in our case there were no significant medical records that could have raised the suspicion of an extramammary disease.…”

Section: Discussionmentioning

confidence: 99%

A Mammary Nodule Mimicking Breast Cancer

Solaini

Bianchi

Filippini

et al. 2014

International Surgery

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Metastases to the breast from extramammary tumors are rare. Several clinical, radiologic, and histologic signs can help to distinguish metastases from breast primary tumors. In the present study, we present a case of a left-sided breast metastasis from renal cancer in a 44-year-old woman whose clinical presentation was a mammary nodule in the upper internal quadrant. The patient underwent quadrantectomy with sentinel lymph node biopsy. The histology revealed a clear cell carcinoma. On computed tomography scan a 538-cm left renal mass with pulmonary, liver, and intrapericardial nodules was found. The patient underwent palliative care and died after 4 months. Metastasis to the breast is rare, but all of those clinical, radiologic, and histologic signs more typical of extramammary malignancies should always be considered in order to choose the best treatment strategy. Key words: Renal cell metastases -Clear cell carcinoma -Breast cancer -Metastases to the breastA 44-year-old woman with no significant medical history presented to the breast outpatient clinic after noticing a solitary, painless, left-sided breast mass.Physical examination revealed a focal, round, smooth, mobile mass at the 10-o'clock position of the left breast. She had no nipple discharge or skin changes, and no palpable axillary or supraclavicular lymphadenopathy. The right breast was normal to palpation. Mammography revealed a solid, smooth nodule in the upper internal quadrant of the left breast (Fig. 1). Ultrasound demonstrated an oval mass in the 10-o'clock position of the left breast measuring 15310 mm (Fig. 2). Fine-needle aspira-

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Metastases to breast simulating ductal carcinoma in situ: Report of two cases and review of the literature

Cited by 42 publications

References 17 publications

Characteristics of metastasis in the breast from extramammary malignancies

Characteristics of metastasis in the breast from extramammary malignancies

The diagnosis of a metastatic breast tumor from ovarian cancer by the succession of a p53 mutation: a case report

A Mammary Nodule Mimicking Breast Cancer

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