A Mammary Nodule Mimicking Breast Cancer

Solaini, Leonardo; Bianchi, Anna; Filippini, L; Lucini, Laura; Simoncini, Edda; Ragni, Fulvio

doi:10.9738/intsurg-d-12-00019.1

Cited by 4 publications

(5 citation statements)

References 6 publications

(5 reference statements)

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“…Histopathologically, images of tumors with a distinct border and no calcification around normal mammary glands or no characteristics of intraductal carcinoma are findings that strongly suggest breast metastasis of malignant tumors of other organs [9]. Moreover, immunohistochemistry can be very valuable when trying to differentiate between a primary cancer originating in the breast and a metastasis to the breast and identify the primary organ of malignant tumors [10,11]. Although histological and immunohistochemical examination is considered feasible to diagnose primary cancer or metastatic tumor, it is very difficult to make preoperative diagnosis by tissue biopsy, like our case.…”

Section: Discussionmentioning

confidence: 99%

Male breast metastasis of ureteral cancer: a case report

et al. 2020

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Background: Breast metastasis from extra-mammary primary tumors is extremely rare. We recently experienced a rare case of a male breast metastasis of ureteral cancer and will provide a case report. Case presentation: A 74-year-old man developed a ureteral cancer and underwent left nephroureterectomy with lymph node dissection. Although enlarged abdominal lymph nodes did not disappear completely after chemoradiotherapy, further extensive therapy was not performed. A mass just below the nipple of his right breast was acknowledged and he visited our department. Histological diagnosis was invasive carcinoma. It was initially diagnosed as a primary breast cancer, and he underwent a mastectomy and a sentinel lymph node biopsy. There was no intraductal lesion and the border of the tumor was clear. It was very similar to that of the previous ureteral cancer. The final diagnosis was breast metastasis of ureteral cancer rather than primary breast cancer. The postoperative course was good, but multiple lung metastases appeared 2 months after surgery. He eventually died of cancerous lymphangiopathy. Conclusion: It is important to accurately diagnose primary breast cancer or breast metastasis so as not to cause extrainvasion, but it was considered difficult to make a complete preoperative diagnosis.

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Section: Discussionmentioning

confidence: 99%

Male breast metastasis of ureteral cancer: a case report

et al. 2020

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“…There has been a report of a case in which the diagnosis of breast cancer by CNB was subsequently revised to intramammary metastasis of renal cancer as the physician became aware that the patient had a history of renal cancer and subsequently performed a repeat microscopic examination with additional immunostaining of the tissue specimen [ 6 ]. Furthermore, a case of breast cancer, as diagnosed by FNAC, that was then revised to metastasis of renal cancer after a partial mastectomy and sentinel lymph node biopsy has been reported [ 7 ]. Due to the limited number of reports on intramammary metastasis, some patients undergo excessive surgery, including axillary operations, after a misdiagnosis of breast cancer instead of a mammary tumor, which places these patients at increased risk for postoperative lymphedema and skin damage caused by radiotherapy [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…Histopathologically, images of tumors with a distinct border and no calcification around normal mammary glands or characteristics of intraductal carcinoma are findings that strongly suggest intramammary metastasis of malignant tumors of other organs [ 8 ]. Moreover, immunohistochemical examination is an important diagnostic method that can be used to identify the primary organ of malignant tumors [ 7 ]. Renal cancer is most commonly positive for RCC and CD10, whereas ER, GCDFP-15, and cytokeratin 7 are rarely expressed [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Intramammary Metastasis in a Patient with a History of Renal Cell Carcinoma: A Case Report

et al. 2018

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Intramammary metastasis of renal cell carcinoma (RCC) is extremely rare, accounting for only 1.5% of all intramammary metastases. Distinguishing intramammary metastases from benign tumors and breast cancer is clinically problematic. Some patients undergo excessive surgery after a misdiagnosis of breast cancer instead of a mammary tumor. We performed a core needle biopsy (CNB) of a breast mass that developed in a 71-year-old woman after surgeries for bilateral RCC and breast cancer, leading to a diagnosis of intramammary metastasis of RCC. In this case, the CNB and immunohistochemical examination were critical for reaching a definitive diagnosis. We conclude that, when examining patients with mammary tumors, establishing their history of malignant tumors may help diagnose intramammary metastasis and select the best treatment strategy.

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“…To best of our knowledge, this is the first case of synchronic breast metastasis from RCC described from Spain. Clinically, breast metastasis presenting as painless, mobile mass, and skin dimpling is rare leading to delayed diagnosis [3,9]. Axillary node involvement is uncommon.…”

Section: Discussionmentioning

confidence: 99%

Breast Metastasis as Initial Presentation of Silent, Synchronic, Widely Metastatic Renal Cell Carcinoma

Ls¹,

Giménez-Barriga²,

Plaza-Loma³

et al. 2015

JCR

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Abstract:Metastasis to breast from extra-mammary sites is much less common as compared to primary ones and only few cases are reported in the literature. Furthermore, very little is known about prognosis and treatment of patients with solid neoplasms metastatic to the breast. If a breast lump is found, it is recommended to perform a bilateral mammogram specially when there is a rapidly enlargement. Here, we describe a case of a young woman with synchronic breast metastasis from asymptomatic, widely spread, renal cell carcinoma, Furhman grade 4. RCC is one of the most aggressive urologic tumors and rarely metastasizes to the breast. This phenomenon takes place in less than 3% of all metastatic renal cell carcinoma and the appearance as first sign of renal disease is exceptional. This case illustrates the importance of histopathological investigation in a breast mass and the potential for rare sites of metastasis in order to prevent unnecessary radical procedures. Also, this report contributes to importance of a proper diagnosis when rare sites of metastatic deposit, like breast, are detected, especially if there is no previous history of neoplasm.

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A Mammary Nodule Mimicking Breast Cancer

Cited by 4 publications

References 6 publications

Male breast metastasis of ureteral cancer: a case report

Male breast metastasis of ureteral cancer: a case report

Intramammary Metastasis in a Patient with a History of Renal Cell Carcinoma: A Case Report

Breast Metastasis as Initial Presentation of Silent, Synchronic, Widely Metastatic Renal Cell Carcinoma

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