Male breast metastasis of ureteral cancer: a case report

Abstract

Background: Breast metastasis from extra-mammary primary tumors is extremely rare. We recently experienced a rare case of a male breast metastasis of ureteral cancer and will provide a case report. Case presentation: A 74-year-old man developed a ureteral cancer and underwent left nephroureterectomy with lymph node dissection. Although enlarged abdominal lymph nodes did not disappear completely after chemoradiotherapy, further extensive therapy was not performed. A mass just below the nipple of his right breast was acknowledged and he visited our department. Histological diagnosis was invasive carcinoma. It was initially diagnosed as a primary breast cancer, and he underwent a mastectomy and a sentinel lymph node biopsy. There was no intraductal lesion and the border of the tumor was clear. It was very similar to that of the previous ureteral cancer. The final diagnosis was breast metastasis of ureteral cancer rather than primary breast cancer. The postoperative course was good, but multiple lung metastases appeared 2 months after surgery. He eventually died of cancerous lymphangiopathy. Conclusion: It is important to accurately diagnose primary breast cancer or breast metastasis so as not to cause extrainvasion, but it was considered difficult to make a complete preoperative diagnosis.

Breast metastases from primary tumor of the urinary tract: case series

“…Breast metastases are rare; however, they must always be considered in the differential diagnosis of a breast lesion because of their poor prognosis and the need for different therapies from those used to treat primary breast cancer [ 1 ].…”

“…They are most often CK7 positive and CK 20 negative, associated with positive hormone receptors, while HER 2 is rarely positive. Thus, the positive expression of mammaglobin, RE, RP, GATA3 and GCDFP.15 helps to support the primitive mammary origin [ 1 , 2 , 10 ].…”

Male breast: An unusual case of metastasis of squamous cell carcinoma of the skin

“…Breast metastasis from extra-mammary neoplasm is a rare condition, accounting for approximately 0.3%-2.7% of all breast malignancies [1] . In women, the most common malignancy that metastasizes to the breast are melanomas, sarcomas, lung cancers, ovarian tumors, renal carcinomas, and thyroid tumors [2 , 3] . In men, metastases to the breast are extremely rare and more frequently caused by prostate cancer [4] .…”

“…In men, metastases to the breast are extremely rare and more frequently caused by prostate cancer [4] . One case of male breast metastasis from ureteral cancer has been reported [2] but no evidences of metastasis originating from cutaneous squamous cell carcinoma (cSCC) in a male breast have been described to our knowledge. We describe a case of an 81-year-old man presenting with a palpable mass of the left breast with final histological diagnosis of breast metastasis of non-keratoblastic cSCC.…”