Metaplastic ossification of a cervical sialocoele in a dog

Prassinos, N. N.; Tontis, D.; Adαmama-Moraitou, K. K.; Galatos, Apostolos D.; Siochu, A.

doi:10.1111/j.1751-0813.2005.tb13081.x

Cited by 13 publications

(25 citation statements)

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“…Diagnosis of a cervical salivary mucocele usually can be done with no difficulty based on the history, physical examination and cytological examination of the fluid by fine needle aspiration [7]. However, as similar subcutaneous swelling to the cervical salivary mucocele can be associated with sialoadenitis, sialoadenosis, salivary neoplasia, sialolith, cervical abscess, foreign body, hematoma, enlarged lymphnode, tonsil cyst, thyroglossal cyst, cystic Rathke's pouch and brachy cysts, the diagnosis shall be done after differentiating these lesions.…”

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“…Generally, since differentiation of a mucocele from a tumor and congenital cysts is difficult in clinical practice, histopatholgical examination is required for differential diagnosis [2,4]. Microscopically, the wall of a congenital cyst has a true secretory epithelial lining, whereas salivary mucoceles are lined by granulation tissue [4,7].…”

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“…Ectopic ossification can be subdivided into three classifications: heterotopic ossification, osseous metaplasia, and osseus choristoma [6,7]. The term osseus choristoma means microscopically normal bone in abnormal sites but generally implies a congenital or developmental tumor [7]. Heterotopic ossification usually occurs as secondary to metastatic calcification from systemic disease or dystrophic calcification from local tissue disease [6,7].…”

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Salivary Mucocele with Osseous Metaplasia in a Dog

Park

Han

Hong

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. A 4-year-old, male, dachshund was referred to a certain local veterinary hospital because of a soft and fluctuant swelling in the left upper cervical region. The swelling was surgically removed and appeared to be filled with bloody mucus. Grossly, the swelling was identified as salivary mucocele and showed small multifocal whitish ossified tissue on its surface. Microscopically, the wall of salivary mucocele appeared as granulation tissue surrounding mucin, which was composed of loose edematous and vascularized connective tissue containing chronic inflammatory cells such as lymphocytes, plasma cells and macrophages. Characteristically, present case had ossifying components formed by metaplastic spindle cells in the wall of salivary mucocele. Therefore, the present case was diagnosed as salivary mucocele with osseous metaplasia in a dog.KEY WORDS: canine, osseous metaplasia, salivary mucocele.J. Vet. Med. Sci. 71 (7): [975][976][977] 2009 A salivary mucocele is an accumulation of saliva that has leaked from a injured salivary gland or duct and is lined with granulation tissue [4,8]. Salivary mucoceles can be classified according to the location into cervical mucocele, sublingual mucocele, pharyngeal mucocele, zygomatic mucocele and complex mucocele [4]. A cervical mucocele is an accumulation of saliva in the deeper part of the intermandibular region or the upper cervical region, while a sublingual mucocele (ranula) is formed in the sublingual region, a pharyngeal mucocele in the adjacent tissue to the pharynx, and a zygomatic mucocele in the ventral part of the globe. A complex mucocele is composed of 2 or more types of mucoceles [4]. The most common places in which mucoceles associated with the sublingual gland develop are the cervical, sublingual and pharyngeal areas. The cause of salivary mucocele is not identified, however, blunt trauma, foreign body and sialolith have been suspected as major causes of salivary mucocele [2]. The saliva leaks from the torn salivary gland or duct, and accumulates in the adjacent tissue. Consequently, the accumulated saliva induces an inflammatory response [1,4,8]. To prevent saliva from migrating further, the wall of granulation tissue is developed in response to the inflammation. In the present case, an unusual case of salivary mucocele with osseous metaplasia in a dog is described.A 4-year-old, male, dachshund was referred to a certain local veterinary hospital because of a soft and fluctuant swelling in the left submandibular region. On physical examination, a soft and fluctuant mass was placed subcutaneously in the left upper cervical region. The mass was relatively movable and painless. Through fine needle aspiration, blood-tinged mucus fluid was observed and a cervical salivary mucocele was suspected. The fluctuant mass was removed with difficulty surgically under general anesthesia owing to the firm attachment of capsule of the fluctuant mass with adjacent connective tissue (Fig. 1). It was referred to Department of Veterinary Pathology, Kyungpook National U...

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Salivary Mucocele with Osseous Metaplasia in a Dog

Park

Han

Hong

et al. 2009

The Journal of Veterinary Medical Science

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“…Histopathologically, the diagnosis of SGCs can be confirmed using a mucusspecific stain method such as PAS [1,4]. For the differential diagnosis of salivary gland masses including benign cysts and malignant tumors, histopathological examination is required [1,4,6,12]. In the present case, benign SGCs were suspected clinically, but the large foamy cells in the stamp smear and pathological sections are so similar to liposarcoma cells and lipoblasts that it might mislead practitioners, clinical pathologists and pathologists.…”

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Pathological Features of Salivary Gland Cysts in a Shiba Dog with GM1 Gangliosidosis: A Possible Misdiagnosis as Malignancy

Rahman

Kawaguchi

Miyoshi

et al. 2012

The Journal of Veterinary Medical Science

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ABSTRACT. Salivary gland cysts are often concurrent with GM1 gangliosidosis in Shiba dogs. Although the etiology is unknown, these cysts may be misdiagnosed as malignant due to the accumulation of foamy cells. The present study investigated the cytological, histopathological, immunohistochemical and electron microscopic characteristics of salivary gland cysts in a Shiba dog affected with GM1 gangliosidosis. The salivary gland masses were surgically enucleated and examined clinicopathologically and pathologically in a 7-month-old Shiba dog with GM1 gangliosidosis. Many large cells with rich cytoplasm including vacuoles of various sizes, i.e., foamy cells, were observed in stamp smears from the cut-surface of the masses and histopathologically in major parts of the cyst wall. Some of these foamy cells presented features similar to a spider-web appearance. The foamy cells were confirmed to have originated from macrophages based on marked immunohistochemical expression of vimentin, HLA-DR, lysozyme and Iba1. An ultrastructural study demonstrated electron-dense vesicular structures in the vacuolated cells. Therefore, the masses were diagnosed pathologically as benign salivary gland cysts with accumulation of foamy cells. In conclusion, the histopathological features of the salivary gland cysts in this Shiba dog were similar to those of lipoma and/or liposarcoma. In such cases, immunohistochemical and ultrastructural examinations were useful in the differential diagnosis. Practitioners, clinical pathologists and pathologists should take GM1 gangliosidosis into consideration when they encounter salivary gland cysts in Shiba dogs.

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General Oral Pathology

Lobprise¹

2018

Wiggs's Veterinary Dentistry

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Metaplastic ossification of a cervical sialocoele in a dog

Cited by 13 publications

References 15 publications

Salivary Mucocele with Osseous Metaplasia in a Dog

Salivary Mucocele with Osseous Metaplasia in a Dog

Pathological Features of Salivary Gland Cysts in a Shiba Dog with GM1 Gangliosidosis: A Possible Misdiagnosis as Malignancy

General Oral Pathology

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