Metaplastic carcinoma of the breast – Case report and review of literature

Kumar, Manoj; Nigam, Jitendra Singh; Khanna, Puja P.; Arora, Abhishek

doi:10.1016/j.ijso.2020.03.005

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Both clinically and radiographically, they present similarly to other breast cancers. Research reports have mentioned tumor presentation in 22 to 91 years [5][6][7]. At diagnosis, axillary lymph node metastasis was observed in 5-56% of cases.…”

Section: Discussionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Breast: An Unusual Clinical Presentation

Bhargava,

Agrawal

2024

Cureus

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Breast sarcomatoid carcinoma, which are malignant tumors that form from the mesenchymal tissue of the mammary gland, are extremely uncommon and come in two varieties: primary and secondary (development associated to therapy). Breast sarcomas are malignancies that are aggressive and have a bad prognosis. Multidisciplinary surgery, chemotherapy, and radiotherapy are among the treatment possibilities. This case report reports a case of 35-year-old female presented to our hospital with a palpable tumor in her right breast and pungent discharge from her nipples. These signs persisted for over five years. A sarcomatoid breast cancer was discovered by postoperative histology.

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Section: Discussionmentioning

confidence: 99%

Sarcomatoid Carcinoma of the Breast: An Unusual Clinical Presentation

Bhargava,

Agrawal

2024

Cureus

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“…The epithelial origin of metaplastic carcinoma is mostly dependent on demonstrating a positive expression of cytokeratin, at least focally on immunohistochemistry. It also stains for vimentin and smooth muscle actin [6,7]. Because metaplastic carcinoma is uncommon and heterogeneous, the best course of treatment has not been determined.…”

Section: Discussionmentioning

confidence: 99%

“…The role of targeted therapy and conventional chemotherapy is limited by the lack of hormone receptor expression and the human epidermal growth factor 2 receptor (HER2). While post-mastectomy radiotherapy was linked to advantages in overall survival in the advanced stage but not in the early stage, post-lumpectomy radiotherapy was associated with greater overall survival in both the early and advanced stages of the carcinoma [6,8]. The significant predictors of survival include the duration of symptoms, stage of the tumor, size of the tumor, and status of axillary nodes [6].…”

Section: Discussionmentioning

confidence: 99%

A Rare and Intriguing Case Report of Metaplastic Breast Carcinoma

Kani,

Chander,

Sonti

et al. 2024

Cureus

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Metaplastic breast carcinoma (MBC) is a rare and aggressive subtype of breast cancer characterized by the presence of both epithelial and mesenchymal components within the tumor. Its clinical and radiological appearance is comparable to other types of breast cancer, but it grows rapidly. The diagnosis of metaplastic carcinoma is largely based on the epithelial origin of the cells confirmed by immunohistochemistry (IHC). Compared to invasive ductal carcinoma, metaplastic carcinoma has a worse overall survival rate. Any patient with a rapidly growing breast mass should be assessed with suspicion of sarcomatoid or metaplastic malignant neoplasm. We report this case due to its rarity and the complex nature of the disease.

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“…It was first described by Edmondson in 1956. [1][2][3][4][5][6] In her review of liver tumours, Edmondson presented a study report of a 14-year-old girl with unusually long survival after resection of this liver tumour (it was established later that this cancerous tumour was fibrolamellar carcinoma). And in 1980, fibrolamellar cancer was widely recognized as a separate clinical component after two reports by Craig and Berman in 1980 were simultaneously published.…”

Section: Introductionmentioning

confidence: 99%

Fibrolamellar hepatocellular carcinoma: Case report

et al. 2020

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Introduction: Fibrolamellar carcinoma is a rare primary hepatic malignant tumour, which was first described as a pathological variant of hepatocellular carcinoma. Aim: The aim of the paper is to discuss the case report of surgical treatment of a multicentric form of presumably fibrolamellar carcinoma significantly exceeding the Barcelona Clinic Liver Cancer staging system criteria, although tumour size and multi-organ lesions are not a contraindication to resection. Case study: This case report is an original one because the surgical intervention was performed on a patient with a multicentric fibrolamellar hepatocellular carcinoma with the initial foci of 16.0 × 12.0 × 9.0 cm and 10.5 × 8.7 × 7.5 cm. Results and discussion: The surgical intervention (right hemihepatectomy, lymphatic dissection D2) was performed as an independent treatment without prior chemotherapy. Conclusions: The surgical treatment occurred 5 years ago, and at the time of writing there has been no relapse and no sign of progression.

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Metaplastic carcinoma of the breast – Case report and review of literature

Cited by 4 publications

References 22 publications

Sarcomatoid Carcinoma of the Breast: An Unusual Clinical Presentation

Sarcomatoid Carcinoma of the Breast: An Unusual Clinical Presentation

A Rare and Intriguing Case Report of Metaplastic Breast Carcinoma

Fibrolamellar hepatocellular carcinoma: Case report

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