Metals, metallothioneins and oxidative stress in blood of autistic children

Vergani, Laura; Lanza, Cristina; Rivaro, Paola; Luisa, Abelmoschi M.; Shyti, Genti; Veneselli, E.; Minniti, G.; Grasselli, Elena; Canesi, Laura; Voci, Adriana

doi:10.1016/j.rasd.2010.04.010

Cited by 68 publications

(56 citation statements)

References 51 publications

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“…This could find a support through considering the work of Shearer et al [52] in which they observed lower Ca 2+ concentrations in the hair of autistic population and that of Krey and Dolmetsch [53] in which they proved that some forms of autism are caused by failures in activity-dependent regulation of neural development due to mutations of several voltage-gated and ligand-gated ion channels that regulate neuronal excitability and Ca 2+ signalling. On the other hand, the recorded lower concentration of Ca 2+ is not in accordance with the recent work of Laura et al (2011) [54] which reported higher Ca 2+ concentrations in plasma of Italian autistic patients compared to age and gender matching controls. The reduced plasma Ca 2+ concentrations of the present study could be associated with high intracellular brain Ca 2+ in autistics compared to control subjects.…”

Section: Discussioncontrasting

confidence: 86%

Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia

El‐Ansary

Bacha

Al-Ayadhi

2011

Journal of Neuroinflammation

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ObjectivesAutism is a developmental disorder characterized by social and emotional deficits, language impairments and stereotyped behaviors that manifest in early postnatal life. This study aims to clarify the relationship amongst absolute and relative concentrations of K+, Na+, Ca2+, Mg2+ and/or proinflammatory and proapoptotic biomarkers.Materials and methodsNa+, K+, Ca2+, Mg2+, Na+/K+, Ca2+/Mg2+ together with IL6, TNFα as proinflammatory cytokines and caspase3 as proapoptotic biomarker were determined in plasma of 25 Saudi autistic male patients and compared to 16 age and gender matching control samples.ResultsThe obtained data recorded that Saudi autistic patients have a remarkable lower plasma caspase3, IL6, TNFα, Ca2+ and a significantly higher K+ compared to age and gender matching controls. On the other hand both Mg2+ and Na+ were non-significantly altered in autistic patients. Pearson correlations revealed that plasma concentrations of the measured cytokines and caspase-3 were positively correlated with Ca2+ and Ca2+/K+ ratio. Reciever Operating Characteristics (ROC) analysis proved that the measured parameters recorded satisfactory levels of specificity and sensitivity.ConclusionAlteration of the selected measured ions confirms that oxidative stress and defective mitochondrial energy production could be contributed in the pathogenesis of autism. Moreover, it highlights the relationship between the measured ions, IL6, TNFα and caspase3 as a set of signalling pathways that might have a role in generating this increasingly prevalent disorder. The role of ions in the possible proinflammation and proapoptic mechanisms of autistics' brains were hypothesized and explained.

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Section: Discussioncontrasting

confidence: 86%

Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia

El‐Ansary

Bacha

Al-Ayadhi

2011

Journal of Neuroinflammation

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“…Biomarkers included altered levels of oxidative stress defence systems, including metallothioneins and antioxidant enzymes. 215 Other markers of oxidative stress, associated heavy metal toxicity and/or low detoxification capacity included abnormal markers of thiol metabolism, 216 transsulfuration abnormalities, 30 urinary organic acids, 29 and increased lead and potassium ions, ATPase activity and lipid peroxidation products. 217 …”

Section: Health Promotion and Chronic Disease Prevention In Canadamentioning

confidence: 99%

Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

Montigny

Ofner

et al. 2017

Health Promot Chronic Dis Prev Can

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Introduction: The number of children diagnosed with autism spectrum disorder (ASD) has been rapidly rising in the past decade. The etiology of this disorder, however, is largely unknown, although the environmental relative to the genetic contribution is substantial. We conducted a scoping review to comprehensively assess the current state of knowledge of the environmental factors present from preconception to early life associated with ASD, and to identify research gaps.

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“…In clinical trials, the association between oxidative stress and autism has not been established and in some cases, literature reports present conflicting results. The SOD activity was either decreased in plasma [144] and erythrocytes [141,150] or increased in plasma [151] and in erythrocytes [152][153][154]. The CAT activity was reduced in erythrocytes [152,154], while did not change in plasma [153].…”

Section: Human Studiesmentioning

confidence: 99%

“…The SOD activity was either decreased in plasma [144] and erythrocytes [141,150] or increased in plasma [151] and in erythrocytes [152][153][154]. The CAT activity was reduced in erythrocytes [152,154], while did not change in plasma [153]. A bi-directional changes of the GSH-Px activity were also shown (a fall of the activity in plasma [144,150,151,155] and erythrocytes [141,150], or a rise of the activity in plasma [153]).…”

Section: Human Studiesmentioning

confidence: 99%

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

Smaga

Niedzielska

Gawlik

et al. 2015

Pharmacological Reports

217

123

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The pathophysiology of psychiatric diseases, including depression, anxiety, schizophrenia and autism, is far from being fully elucidated. In recent years, a potential role of the oxidative stress has been highlighted in the pathogenesis of neuropsychiatric disorders. A body of clinical and preclinical evidence indicates that psychiatric diseases are characterized by higher levels of oxidative biomarkers and with lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review current knowledge on the role of the oxidative stress in psychiatric diseases, based on clinical trials and animal studies, in addition, we analyze the effects of drug-induced modulation of oxidative balance and explore pharmacotherapeutic strategies for oxidative stress reduction.

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Metals, metallothioneins and oxidative stress in blood of autistic children

Cited by 68 publications

References 51 publications

Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia

Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia

Environmental factors associated with autism spectrum disorder: a scoping review for the years 2003–2013

Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism

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