Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disorders

Rivera, Santiago; García-González, Laura; Khrestchatisky, Michel; Baranger, Kévin

doi:10.1007/s00018-019-03178-2

Cited by 80 publications

(91 citation statements)

References 224 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of CAA may promote the deposition of ECM as a generalized response to stress on the BM. Conversely, we find microvasculature in the presence of high ADNC has a decrease in BM ECM content that could reflect a response to neuronal loss, pericyte drop-out and increased matrix metalloprotease activity [60,61]. Conflicting results obtained in efforts to quantify changes in ECM associated with development of brain pathology likely reflect: (1) differences in ECM composition between the different brain regions that were sampled, (2) variations in the local microenvironment of plaques and tangles within a specific brain region, and (3) differences in the methods or techniques utilized to measure specific ECM components.…”

Section: Discussionmentioning

confidence: 79%

The microvascular extracellular matrix in brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)

Damodarasamy

Vernon

Pathan

et al. 2020

Fluids Barriers CNS

View full text Add to dashboard Cite

Background The microvasculature (MV) of brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA), in the absence of concurrent pathologies (e.g., infarctions, Lewy bodies), is incompletely understood. Objective To analyze microvascular density, diameter and extracellular matrix (ECM) content in association with ADNC and CAA. Methods We examined samples of cerebral cortex and isolated brain microvasculature (MV) from subjects with the National Institute on Aging-Alzheimer's Association (NIA-AA) designations of not-, intermediate-, or high ADNC and from subjects with no CAA and moderate-severe CAA. Cases for all groups were selected with no major (territorial) strokes, ≤ 1 microinfarct in screening sections, and no Lewy body pathology. MV density and diameter were measured from cortical brain sections. Levels of basement membrane (BM) ECM components, the protein product of TNF-stimulated gene-6 (TSG-6), and the ubiquitous glycosaminoglycan hyaluronan (HA) were assayed by western blots or HA ELISA of MV lysates. Results We found no significant changes in MV density or diameter among any of the groups. Levels of BM laminin and collagen IV (col IV) were lower in MV isolated from the high ADNC vs. not-ADNC groups. In contrast, BM laminin was significantly higher in MV from the moderate-severe CAA vs. the no CAA groups. TSG-6 and HA content were higher in the presence of both high ADNC and CAA, whereas levels of BM fibronectin and perlecan were similar among all groups. Conclusions Cortical MV density and diameter are not appreciably altered by ADNC or CAA. TSG-6 and HA are increased in both ADNC and CAA, with laminin and col IV decreased in the BM of high ADNC, but laminin increased in moderate-severe CAA. These results show that changes in the ECM occur in AD and CAA, but independently of one another, and likely reflect on the regional functioning of the brain microvasculature.

show abstract

Section: Discussionmentioning

confidence: 79%

The microvascular extracellular matrix in brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)

Damodarasamy

Vernon

Pathan

et al. 2020

Fluids Barriers CNS

View full text Add to dashboard Cite

show abstract

“…ADAMTS20 belongs to the ADAMTS (a disintegrin and metallopeptidase with thrombospondin motifs) proteins family, which is a secretory metalloproteinase (Hubmacher & Apte, 2015). ADAMTS proteins generally contain multiple domains including a metalloproteinase domain and a disintegrin domain, which could both have an important impact on the extracellular matrix (ECM) (Rivera et al, 2019;Zhang et al, 2019b;Zhong & Khalil, 2019). ECM participates in cell proliferation, differentiation, and migration, and then regulates chicken growth and development (Iyoda & Fukai, 2012;Katayama et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages

Zhang

et al. 2020

PeerJ

View full text Add to dashboard Cite

Background. The meat quality of yellow feathered broilers is better than the quality of its production. Growth traits are important in the broiler industry. The exploration of regulation mechanisms for the skeletal muscle would help to increase the growth performance of chickens. At present, some progress has been made by researchers, but the molecular mechanisms of the skeletal muscle still remain unclear and need to be improved. Methods. In this study, the breast muscles of fast-and slow-growing female Jinghai yellow chickens (F4F, F8F, F4S, F8S) and slow-growing male Jinghai yellow chickens (M4S, M8S) aged four and eight weeks were selected for transcriptome sequencing (RNA-seq). All analyses of differentially expressed genes (DEGs) and functional enrichment were performed. Finally, we selected nine DEGs to verify the accuracy of the sequencing by qPCR. Results. The differential gene expression analysis resulted in 364, 219 and 111 DEGs (adjusted P-value ≤ 0.05) for the three comparison groups, F8FvsF4F, F8SvsF4S, and M8SvsM4S, respectively. Three common DEGs (ADAMTS20, ARHGAP19, and Novel00254) were found, and they were all highly expressed at four weeks of age. In addition, some other genes related to growth and development, such as ANXA1, COL1A1, MYH15, TGFB3 and ACTC1, were obtained. The most common DEGs (n = 58) were found between the two comparison groups F8FvsF4F and F8SvsF4S, and they might play important roles in the growth of female chickens. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway also showed some significant enrichment pathways, for instance, extracellular matrix (ECM)-receptor interaction, focal adhesion, cell cycle, and DNA replication. The two pathways that were significantly enriched in the F8FvsF4F group were all contained in that of F8SvsF4S. The same two pathways were ECM-receptor interaction and focal adhesion, and they had great influence on the growth of chickens. However, many differences existed between male and female chickens in regards to common DEGs and KEGG pathways. The results would help to reveal the regulation mechanism of the growth and development of chickens and serve as a guideline to propose an experimental design on gene function with the DEGs and pathways. M. 2017. Sound analysis to model weight of broiler chickens. Francisco CL, Jorge AM, Dalpaisilva M, Carani FR, Cabeço LC, Silva SR. 2011. Muscle fiber type characterization and myosin heavy chain (MyHC) isoform expression in Mediterranean buffaloes. Meat Science 88(3):535-541 DOI 10.1016/j.meatsci.2011.02.007. Friedrich RE, Scheuer HA, Holtje W. 2019. The effect of bisphosphonate medication on orthodontics and orthognathic surgery in patients with osteogenesis imperfecta. GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW 8:Doc06 . 2019. Synergistic effects of recombinant Lentiviral-mediated BMP2 and TGF-beta3 on the osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro. Cytokine 120:1-8 Noda M. 2016. Collagens VI and XII form complexes mediating osteoblast interact...

show abstract

Section: Discussionmentioning

confidence: 99%

Peer Review #2 of "Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages (v0.1)"

2020

View full text Add to dashboard Cite

Background: The meat quality of yellow feathered broilers is better than the quality of its production. Growth traits are important in the broiler industry. The exploration of regulation mechanisms for the skeletal muscle would help to increase the growth performance of chickens. At present, some progress has been made by researchers, but the molecular mechanisms of the skeletal muscle still remain unclear and need to be improved. Methods: In this study, the breast muscles of fast-and slow-growing female Jinghai yellow chickens (F4F, F8F, F4S, F8S) and slow-growing male Jinghai yellow chickens (M4S, M8S) aged four and eight weeks were selected for transcriptome sequencing (RNAseq). All analyses of differentially expressed genes (DEGs) and functional enrichment were performed. Finally, we selected nine DEGs to verify the accuracy of the sequencing by qPCR. Results: The differential gene expression analysis resulted in 364, 219 and 111 DEGs (adjusted P-value ≤0.05) for the three comparison groups, F8FvsF4F, F8SvsF4S, and M8SvsM4S, respectively. Three common DEGs (ADAMTS20, ARHGAP19, and Novel00254) were found , and they were all highly expressed at four weeks of age. In addition, some other genes related to growth and development, such as ANXA1, COL1A1, MYH15, TGFB3 and ACTC1, were obtained. The most common DEGs (n =58) were found between the two comparison groups F8FvsF4F and F8SvsF4S, and they might play important roles in the growth of female chickens. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway also showed some significant enrichment pathways, for instance, extracellular matrix (ECM)-receptor interaction, focal adhesion, cell cycle, and DNA replication. The two pathways that were significantly enriched in the F8FvsF4F group were all contained in that of F8SvsF4S. The same two pathways were ECM-receptor interaction and focal adhesion, and they had great influence on the growth of chickens. However, many differences existed between male and female chickens in regards to common DEGs and KEGG pathways. The results would help to reveal the regulation mechanism of the growth and

show abstract

Metalloproteinases and their tissue inhibitors in Alzheimer’s disease and other neurodegenerative disorders

Cited by 80 publications

References 224 publications

The microvascular extracellular matrix in brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)

The microvascular extracellular matrix in brains with Alzheimer’s disease neuropathologic change (ADNC) and cerebral amyloid angiopathy (CAA)

Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages

Peer Review #2 of "Transcriptome for the breast muscle of Jinghai yellow chicken at early growth stages (v0.1)"

Contact Info

Product

Resources

About