Metalloproteases 2 and 9, Lp-PLA2 and Lipoprotein Profile in Coronary Patients

Increased MMP-2 in healthy postmenopausal women

“…14 In accordance with this concept, we found an increase in MMP-9 in patients with diagnosed coronary artery disease. 15 In accordance to what it is known, PMW presented higher BMI and waist circumference. It must be taken into account that adipose tissue can also contribute to the release of MMP-2 into circulation, based on data reported by other authors showing that the expression of MMP-2 was induced in the adipose tissue.…”

Juvenile exposure to a high fat diet promotes behavioral and limbic alterations in the absence of obesity

“…LpPLA2 activity was measured following the radiometric assay described by Blank et al (1983) with few modifications (Muzzio et al, 2009). The separation of the released radiolabeled acetate from the lipid substrate was carried out by phase-phase partitioning and measurement of the radioactivity in the aqueous phase.…”

Serum lipids and cardiac function correlate with nitrotyrosine and MMP activity in coronary artery disease patients

“…However, neither HDL cholesterol, nor triglyceride levels correlated with MMP-2 activity. According to our best knowledge, MMP-2 activity has been investigated by only one previous study in CAD patients [30], in which a negative correlation between serum MMP-2 activity and HDL cholesterol was found, however, other correlations were not assessed. In another study [31], plasma MMP-2 protein level was shown to correlate negatively with HDL cholesterol in CAD patients.…”