Increased MMP-2 in healthy postmenopausal women

Muzzio, María Luz; Miksztowicz, Verónica; Repetto, Esteban Martín; Brites, Fernando; Berg, Gabriela; Schreier, Laura

doi:10.1258/acb.2011.011041

Cited by 7 publications

(4 citation statements)

References 16 publications

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“…21 In our laboratory, we found increased MMP-2 plasma activity in women with MS, 22 which correlates with vascular cell adhesion molecules involved in the plaque development. 23 In accordance with the results obtained in other studies, Hopps et al showed an increase in plasma concentrations of MMP-2 and MMP-9 and their inhibitors (TIMP-1 and TIMP-2) in diabetic and nondiabetic subjects with MS. 24 However, other authors found an increase in pro-MMP-9 and TIMP-1 levels, which are associated with raised concentrations of inflammatory markers and adhesion molecules, without differences in MMP-2 and TIMP-2 values in comparison with healthy controls. 25 The different stages of the CVD could be a main factor in conditioning the circulating levels of MMPs.…”

Section: Mmps and Mssupporting

confidence: 88%

Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes

Berg

Miksztowicz²

2015

MNM

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Matrix metalloproteinases (MMPs) constitute a family of more than 25 calciumdependent, zinc-containing endopeptidases, synthesized by multiple cell types. These enzymes play an important role during physiological tissue development and remodeling and angiogenesis, as well as in pathophysiological conditions such as obesity and atherosclerotic process. Moreover, circulating levels of MMPs have emerged as potential biomarkers of cardiovascular disease. MMPs are regulated by different factors such as insulin resistance and obesity. Different components of the metabolic syndrome have been identified as possible stimulus for the synthesis and activity of MMPs. On the other hand, pro-inflammatory and anti-inflammatory cytokines, such as leptin and adiponectin, respectively, are associated with the regulation of MMPs. Leptin induces expression of MMP-2 activators as well as expression of MMP-2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-1 in different human cells. Adiponectin may play a protective role in plaque rupture through selectively increasing TIMP expression. The hepatic manifestation of metabolic syndrome is nonalcoholic fatty liver disease (NAFLD). MMPs may remodel the liver parenchyma during the process of liver fibrosis. MMP-2 and MT1-MMP have been considered to be fibrogenic enzymes.There are few studies analyzing the role of MMPs in NAFLD, and most of them include study on mRNA expression, but even the results on their expression pattern remains controversial. MMPs could be considered as possible therapeutic targets. Different studies demonstrated that metformin, thiazolidinediones, and antibiotics could have inhibitory effects on the expression of MMPs; however, a rational study of lifestyle modifications as well as further studies of pharmacological therapies that influence MMPs are necessary to generate the information that physicians will probably need to improve the treatment of patients. The aim of this revision is to update the data about MMPs in the pathogenesis and progression of metabolic syndrome and the possible effect of different drugs on the behavior of these enzymes.

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Section: Mmps and Mssupporting

confidence: 88%

Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes

Berg

Miksztowicz²

2015

MNM

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“…12,13,15,16 The increase in MMPs observed in postmenopausal women with MS by Mieczkowska et al 13 might have been influenced by menopausal status, as some authors have demonstrated elevated plasma levels and activity of MMP-2 in healthy 45 and in overweight or obese 46 postmenopausal women. However, only few researches have examined metalloprotease expression and activity in MS, and that could explain the discrepancy of these results.…”

Section: Discussionmentioning

confidence: 99%

Gelatinases and Their Tissue Inhibitors in a Group of Subjects with Metabolic Syndrome

Hopps

Presti

Montana

et al. 2013

Journal of Investigative Medicine

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“…MMP2 activity by quantitative zymography (an electrophoretic technique) is higher in healthy postmenopausal women than in premenopausal women, although the number of subjects was small. 137 MMP2 activity correlated with lipid profile, high sensitivity C-reactive protein (CRP) (immunoturbidometric assay) and soluble vascular cell adhesion molecules by enzyme-linked immunosorbent assay (ELISA).…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Biochemistry of the menopause

Honour

2017

Ann Clin Biochem

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The life of a human female is characterized from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the perimenopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins. These changes are superimposed with effects of aging, social and metabolic factors, daily activity and well-being. Although the menopause is entirely natural, in some cases ovarian failure can occur earlier than usual; this is pathological and warrants careful biochemical investigations to distinguish it from conditions causing infertility. Elderly females are affected by a range of clinical disorders including endocrine, cardiovascular, skeletal, urogenital tract and immunological systems, body mass, vasomotor tone, mood and sleep pattern. Reference intervals for many diagnostic biochemical tests for the menopause need to be used when interpreting results in clinical investigations for patient management. The standardization and harmonization of assays are being addressed. Many women now choose to develop their career before bearing children, and the health service has had to change services around this. This review does not cover screening for and tests during pregnancy. The review is timely since the population is aging and there will be more demand on healthcare services.

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Increased MMP-2 in healthy postmenopausal women

Abstract: In postmenopause, the increase in MMP-2 reflects the systemic specific inflammatory process that accompanies atherogenesis.

Cited by 7 publications

References 16 publications

Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes

Metalloproteinases in the pathogenesis and progression of metabolic syndrome: potential targets for improved outcomes

Gelatinases and Their Tissue Inhibitors in a Group of Subjects with Metabolic Syndrome

Biochemistry of the menopause

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