Metallocene–DNA: Synthesis, Molecular and Electronic Structure and DNA Incorporation of C5-Ferrocenylthymidine Derivatives

Metal–Carbon Bonds in Biopolymer Conjugates: Bioorganometallic Nucleic Acid Chemistry

“…23 Houlton and co-workers have attached ferrocene to the 5-position of thymidine via single, double, and, again unsuccessfully, triple bonds. 43 They successfully functionalized cytidine 10 using the same methodology and attached the resulting strand to a silicon surface. 44 Ferrocene was also appended to the N3 of thymidine, 45 which was then 6 …”

Membrane-Anchored DNA Assembly for Energy and Electron Transfer

“…The DMT protected deoxyuridine, 5′-dimethoxytrityl-5-iodo-2′-deoxyuridine, was prepared according to a literature procedure in near quantitative yield and the spectroscopic data were in accordance with that published. 14 The synthesis of the porphyrin starting material 1 (Scheme 1) is described elsewhere. 15 De-oxygenation of reaction mixtures was achieved by bubbling argon through the solution for 30 minutes.…”

A new chitosan–thymine conjugate: Synthesis, characterization and biological activity

“…Phenanthridinium-nucleobase conjugates [1], metallocene-nucleobase conjugates [2], symmetrical and unsymmetrical ˛,ω-nucleobase mono-& bis-amide conjugates [3], cyclodextrin-DNA conjugate [4], ferrocene-bis(nucleobase) conjugates [5], neamine-nucleoside conjugates [6], DNA-peptide conjugates [7], peptide-nucleobase conjugates, nucleobase PNA conjugates [8] are few examples that can inhibit the expression a specific DNA or mRNA molecule, inducing a blockade in the transfer of genetic information from DNA to protein either by antigene or antisense strategy. Single stranded domains of DNA and RNA play an essential role in a number of processes in living cells including those involving viruses.…”