Metallic taste prevalence in patients treated for cancer: a systematic literature review and meta-analysis

Buiret, Guillaume; Thomas‐Danguin, Thierry; Féron, Gilles

doi:10.1007/s00520-022-06904-y

Cited by 5 publications

(3 citation statements)

References 60 publications

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“…An interesting study by Dhuibhir et al shows a high prevalence of taste and smell alterations in newly diagnosed cancer patients before treatment [ 38 ]. Taste and smell alterations are very disabling side effects in oncologic patients, impacting the daily lives of cancer patients [ 39 , 54 , 55 ]. Other studies demonstrate the fact that TSAs during chemotherapy have a strong impact on the daily life of patients; these studies hypothesize that these patients have a reduced quality of life, suffer weight loss and nutritional deficiencies, and obtain unfavorable therapeutic outcomes [ 33 , 42 , 43 , 44 , 56 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Taste and Smell Alterations (TSAs) in Cancer Patients

Rosati,

Mastino,

Romeo

et al. 2024

Diseases

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Recently, smell and taste disorders have seen renewed interest, as these symptoms are frequent complications of SARS-CoV-2 infection, since approximately 60% of patients affected by COVID-19 have shown olfactory and gustatory alterations. Otolaryngology pays attention to taste and smell abnormalities (TSAs), especially when associated with oncology. TSAs are common symptoms in people affected by cancer, yet they are ignored and underestimated. The clinical outcome of TSAs in cancer evidences the importance of identifying them with chemotherapy or radiotherapy in general, and they are associated with many types of cancer. We recognize the findings of the literature on TSAs in cancer, evaluating how it is important to consider and identify these disorders concerning reduced food enjoyment or inappropriate nutrient intake, and modulating the nutritional status, quality of life, and impact of therapy. This review aims to critically evaluate and recognize the assessment and clinical perspectives of taste and smell disorders in a cancer population.

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Section: Resultsmentioning

confidence: 99%

Taste and Smell Alterations (TSAs) in Cancer Patients

Rosati,

Mastino,

Romeo

et al. 2024

Diseases

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“…In further infection experiments, it is necessary to test the potential for transmission of the strain across species and its pathogenicity to brood geese. The innate immune response mechanism of goose astrovirus mainly includes that infection of goose astrovirus can trigger high levels of iNOS and thus limit replication of goose astrovirus ( Buiret et al, 2022 ). The ORF2 P2 domain of goose astrovirus can activate the OASL protein and thus limit its replication ( Ren et al, 2020 ); goose astrovirus can also activate pattern recognition receptors (RIG-I, MDA-5, TLR-3), leading to an increase in MHC-Ia, MHC-Ib and CD81 mRNA, activating humoral and cellular immunity, and thus hindering virus invasion.…”

Section: Discussionmentioning

confidence: 99%

“…Goose astrovirus caused damage to the immune system of the host. INOS participates in most processes of innate immune response and plays an irreplaceable role in the protection against virus infection ( Buiret et al, 2022 ). Expression of iNOS was found to be significantly upward controlled by goose astrovirus infection.…”

Section: The Innate Response To Goose Astrovirusmentioning

confidence: 99%

Infection and innate immune mechanism of goose astrovirus

Jiang

Cheng

et al. 2023

Front. Microbiol.

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Goose astrovirus (GAstV, genus Avian Astrovirus, family Astrovirus) was first discovered in 2005, but was not considered as a pathogen of gosling gout until 2016. Since then, goose astrovirus has erupted in Chinese goslings, causing at most 50% of gosling deaths. By December 2022, the disease had become epidemic and prevailed in goose farms in Jiangsu, Shandong, Anhui, Henan, Guangdong, Liaoning, Sichuan and other places in China. The disease mainly affects goslings within 3 weeks old. The typical symptoms of goose astrovirus are large deposits of urate in the viscera, joint cavity and ureter surface of infected goslings. Goose astrovirus infection can trigger high levels of iNOS, limiting goose astrovirus replication. The ORF2 domain P2 of the goose astrovirus activates the OASL protein, limiting its replication. Goose astrovirus can also activate pattern recognition receptors (RIG-I, MDA-5, TLR-3), causing an increase in MHC-Ia, MHC-Ib and CD81 mRNA, activating humoral and cellular immunity, thereby hindering virus invasion. Goose astrovirus also regulates the activation of IFNs and other antiviral proteins (Mx1, IFITM3, and PKR) in the spleens and kidneys to inhibit viral replication. The innate immune response process in goslings also activates TGF-β, which may be closely related to the immune escape of goose astrovirus. Gaining insight into the infection and innate immune mechanism of goose astrovirus can help researchers study and prevent the severe disease in goslings better.

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The influence of pediatric cancer treatment on taste perception and food hedonics: a systematic review

Curtis,

Tan,

Boltong

et al. 2024

Nutrition Reviews

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Context Children with cancer are at risk of poor nutritional status during treatment and into survivorship. Objectively measured taste perception and self-reported food hedonics are 2 factors that may influence food intake. Objective This 2-armed systematic review examined whether chemotherapy and radiotherapy affect (1) taste perception and (2) hedonic experiences of children and survivors of childhood cancer. Data Source A 2-armed systematic literature search was conducted in the Medline, CINAHL, Embase, and PsychInfo database until June 2022. The effects of cancer treatment on objective taste perception or food hedonics (ie, food liking or aversion and appetite) were examined. Data Extraction Peer-reviewed articles published in English of studies that included children (aged <18 years) or survivors of childhood cancer (any age) were reviewed. Risk of bias was determined using the Evidence Analysis Library by the Academy of Nutrition and Dietetics. Data Analysis A total of 1417 articles in the taste search arm and 3862 articles in the hedonics search arm were identified. Of these, 9 and 4 articles were eligible for review, respectively. Cancer treatment had highly variable effects on taste perception during treatment and into survivorship. Learned food aversions were experienced by children receiving chemotherapy treatment and liking of meats and salty foods by children with cancer was affected. The impact of treatment on appetite varied. Conclusions Cancer treatment did not uniformly affect taste perception. Food liking may be negatively affected, and learned food aversions may develop during cancer treatment. To establish the clinical relevance of childhood cancer treatment on taste perception and food hedonics, more research is required. Systematic Review Registration PROSPERO registration no.CRD42020207127.

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Metallic taste prevalence in patients treated for cancer: a systematic literature review and meta-analysis

Cited by 5 publications

References 60 publications

Taste and Smell Alterations (TSAs) in Cancer Patients

Taste and Smell Alterations (TSAs) in Cancer Patients

Infection and innate immune mechanism of goose astrovirus

The influence of pediatric cancer treatment on taste perception and food hedonics: a systematic review

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