Metallic Structures: Effective Agents to Fight Pathogenic Microorganisms

Pereira, Diana; Carreira, Tiago Soares; Alves, Nuno; Sousa, Ângela; Valente, Joana F. A.

doi:10.3390/ijms23031165

Cited by 17 publications

(12 citation statements)

References 126 publications

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“…Heavy metals, such as copper, gold, silver, and others, have been employed as antibacterial agents over the last few decades owing to their nature and properties [ 1 ]. Considering their changes in oxidation state, many metal ions have the ability to denature and inactivate microorganisms, enzymes, and proteins.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Modi¹,

Inwati

Gacem

et al. 2022

Antibiotics

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Bacterial strains resistant to antimicrobial treatments, such as antibiotics, have emerged as serious clinical problems, necessitating the development of novel bactericidal materials. Nanostructures with particle sizes ranging from 1 to 100 nanometers have appeared recently as novel antibacterial agents, which are also known as “nanoantibiotics”. Nanomaterials have been shown to exert greater antibacterial effects on Gram-positive and Gram-negative bacteria across several studies. Antibacterial nanofilms for medical implants and restorative matters to prevent bacterial harm and antibacterial vaccinations to control bacterial infections are examples of nanoparticle applications in the biomedical sectors. The development of unique nanostructures, such as nanocrystals and nanostructured materials, is an exciting step in alternative efforts to manage microorganisms because these materials provide disrupted antibacterial effects, including better biocompatibility, as opposed to minor molecular antimicrobial systems, which have short-term functions and are poisonous. Although the mechanism of action of nanoparticles (NPs) is unknown, scientific suggestions include the oxidative-reductive phenomenon, reactive ionic metals, and reactive oxygen species (ROS). Many synchronized gene transformations in the same bacterial cell are essential for antibacterial resistance to emerge; thus, bacterial cells find it difficult to build resistance to nanoparticles. Therefore, nanomaterials are considered as advanced solution tools for the fields of medical science and allied health science. The current review emphasizes the importance of nanoparticles and various nanosized materials as antimicrobial agents based on their size, nature, etc.

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Section: Introductionmentioning

confidence: 99%

Nanostructured Antibiotics and Their Emerging Medicinal Applications: An Overview of Nanoantibiotics

Modi¹,

Inwati

Gacem

et al. 2022

Antibiotics

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“…Microorganisms in the rhizosphere now produce various vitamins, antibiotics, plant hormones, and other beneficial molecules for plant growth. Indirectly some microorganisms release secretions that can fight the pathogenicity of harmful organisms to protect plants from the disease [17]. The interaction of microorganisms that produce anti-pathogenic compounds can control the population of parasitic organisms in the rhizosphere [18].…”

Section: Introductionmentioning

confidence: 99%

Analysis of bacterial community from the rhizosphere of shallots (Allium ascalonicum L.) in Brebes, Central Java, using Next Generation Sequencing (NGS) approach

Rosariastuti

Sutami

Sumani

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Brebes is the largest shallot center in Indonesia. This area contributes 18.5 % of national or 57 % of production in Central Java. Farmers regularly spray about 63-93% of pesticides every 3-7 days in their maintenance. It is necessary to improve technology and the use of bacteria in it. This study aimed to determine the diversity of soil bacteria in two types of land use as initial information to optimize its role in overcoming pesticide pollution and increasing the productivity of shallots in the future. Sampling using the purposive sampling method. The bacteria community in the shallot field (KB2) and secondary forest (KB4) using the Next Generation Sequencing technique. Identification using FLASH (V1.2.7) and QIIME (V1.7.0) analysis. The results showed that the soil bacterial community in KB4 was higher than in KB2. The soil bacterial communities in KB2 were seven phyla, while in KB4 were eight phyla. In order of largest to the smallest relative abundance in KB2, including Proteobacteria (0.970%), Actinobacteria (0.015%), Firmicutes (0.014%), Fusobacteriota (0.001%), Desulfobacterota (0.0003%), Bacteroidota (0.0001%), and others (0.011%). In KB4, there are 8 phyla, namely Elusimicrobiota (6.385%), Cyanobacteria (3.192%), Proteobacteria (0.9861%), Actinobacteria (0.0041%), Firmicutes (0.0089%), Desulfobacterota (0.0001%), Bacteroidota (0.0002%), and others (0.0003%).

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“…The antimicrobial performance of antimicrobial metals, such as Cu, Ag, and Zn, are presented, along with the effects of combining them with TiO 2 to create a next generation of antimicrobial coating materials. In this regard, Pereira et al present a recent and comprehensive review on the state-of-the-art in the use of metals, as well as their mechanisms, to fight different clinically relevant microorganisms, such as viruses, bacteria, and fungi [ 2 ]. This review demonstrates that Cu is among the metals with the best antimicrobial properties against several microorganisms and how antiwetting capacity is important to enhance the biocidal activity of metal surfaces or metal-coated surfaces.…”

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confidence: 99%