Metallic nanoparticles irradiated by low‐energy protons for radiation therapy: Are there significant physical effects to enhance the dose delivery?

Heuskin, Anne-Catherine; Gallez, Bernard; Feron, Olivier; Martinive, Philippe; Michiels, Carine; Lucas, Stéphane

doi:10.1002/mp.12362

Cited by 26 publications

(48 citation statements)

References 49 publications

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“…Similar theoretical studies performed using protons showed a negligible macroscopic physical enhancement [47][48][49][50]. Martinez-Rovira et al [50] performed simulations to evaluate the dose enhancement when protons pass through a medium containing GNPs.…”

Section: Physical Enhancementmentioning

confidence: 84%

“…They did not report a significant energy deposition increase for a realistic configuration of the model. In another study, an energy-dependent emission of electrons from GNP surface was reported [48]. For a 5 nm GNP, they reported 8% and 20% increases in number of electrons ejected per incident proton after interaction with 1.3 and 4 MeV protons, respectively, compared to irradiation in the absence of GNPs.…”

Section: Physical Enhancementmentioning

confidence: 90%

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Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient

Penninckx

Heuskin

Michiels

et al. 2020

Cancers

Self Cite

117

123

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Over the last decade, a growing interest in the improvement of radiation therapies has led to the development of gold-based nanomaterials as radiosensitizer. Although the radiosensitization effect was initially attributed to a dose enhancement mechanism, an increasing number of studies challenge this mechanistic hypothesis and evidence the importance of chemical and biological contributions. Despite extensive experimental validation, the debate regarding the mechanism(s) of gold nanoparticle radiosensitization is limiting its clinical translation. This article reviews the current state of knowledge by addressing how gold nanoparticles exert their radiosensitizing effects from a transdisciplinary perspective. We also discuss the current and future challenges to go towards a successful clinical translation of this promising therapeutic approach.

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Section: Physical Enhancementmentioning

confidence: 84%

Section: Physical Enhancementmentioning

confidence: 90%

Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient

Penninckx

Heuskin

Michiels

et al. 2020

Cancers

Self Cite

117

123

View full text Add to dashboard Cite

show abstract

“…Some more recent studies turn to other nanostructures called hydrogenated nanodiamonds (H-NDs) which has been proposed as radiosensitizers, as they exhibit excellent biocompatibility, negative electron affinity that confers a high reactivity with oxygen species (ROS) and an increased induction of DNA DSBs. The characteristics of H-NDs allows electron emission from H-NDs following irradiation by photons and in consequence may enhance the effects of radiation on cancer cells [ 91 , 92 ].…”

Section: Application Of Interaction Of Aunps In Combination With Imentioning

confidence: 99%

“…This year, in an attempt to identify if physical properties are correlated with the survival fraction of cells exposed to low-energy protons in combination with metallic NPs, an interdisciplinary group in Belgium [ 92 ] performed Monte Carlo simulations (based on the latest version of the Geant4 toolkit), assessing also in their study the influence of nanoparticle coating on dose enhancement. They conclude that, although significant efforts will be required to unravel the relevant mechanisms of action, ROS-induced damage and local heating generated from metallic NPs are likely to become fields of importance in radiation therapy research, despite a DNA-centered dogma.…”

Section: Application Of Interaction Of Aunps In Combination With Imentioning

confidence: 99%

Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles

Spyratou

Makropoulou

Efstathopoulos

et al. 2017

Cancers

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Many tumor-targeted strategies have been used worldwide to limit the side effects and improve the effectiveness of therapies, such as chemotherapy, radiotherapy (RT), etc. Biophotonic therapy modalities comprise very promising alternative techniques for cancer treatment with minimal invasiveness and side-effects. These modalities use light e.g., laser irradiation in an extracorporeal or intravenous mode to activate photosensitizer agents with selectivity in the target tissue. Photothermal therapy (PTT) is a minimally invasive technique for cancer treatment which uses laser-activated photoabsorbers to convert photon energy into heat sufficient to induce cells destruction via apoptosis, necroptosis and/or necrosis. During the last decade, PTT has attracted an increased interest since the therapy can be combined with customized functionalized nanoparticles (NPs). Recent advances in nanotechnology have given rise to generation of various types of NPs, like gold NPs (AuNPs), designed to act both as radiosensitizers and photothermal sensitizing agents due to their unique optical and electrical properties i.e., functioning in dual mode. Functionalized AuNPS can be employed in combination with non-ionizing and ionizing radiation to significantly improve the efficacy of cancer treatment while at the same time sparing normal tissues. Here, we first provide an overview of the use of NPs for cancer therapy. Then we review many recent advances on the use of gold NPs in PTT, RT and PTT/RT based on different types of AuNPs, irradiation conditions and protocols. We refer to the interaction mechanisms of AuNPs with cancer cells via the effects of non-ionizing and ionizing radiations and we provide recent existing experimental data as a baseline for the design of optimized protocols in PTT, RT and PTT/RT combined treatment.

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“…Because experimental data contradicted initial expectations that high-Z element nanoparticles would perform poorly as radiosensitizers, several computational studies have been performed to understand the mechanism of sensitization. Although different conclusions have been reported depending on the method used, all simulations agreed that radial dose enhancement is localized around the nanoparticle surface, fading after a few nanometers [80][81][82]. Hence, it has been proposed that the physical radiation-based effect is not primarily responsible for an enhanced therapeutic response, and other nanoparticleinduced biological or chemical processes may be involved [81].…”

Section: Protons As Ionizing Radiationmentioning

confidence: 98%

Nanoparticles for targeted cancer radiotherapy

Pallares

Abergel

2020

Nano Res.

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Radiotherapy, where ionizing radiation is locally delivered either through an external beam or by surgically implanting radionuclidebased seeds in the tumor, is one of the gold standard treatments for cancer. Due to the non-selective nature of radiation, healthy tissue surrounding the cancerous region is usually affected by the treatment. Hence, new strategies, including targeted alpha therapy, are being studied to improve the selectivity of the treatment and minimize side effects. Several challenges, however, limit the current development of targeted radiotherapy, such as the functionalization of the therapeutic agent with targeting vectors and controlling the release of recoiling daughters. Nanoparticles offer unique opportunities as drug delivery vehicles, since they are biocompatible, enhance the cellular uptake of drugs, and are easily functionalized with targeting molecules. In this review, we examine how nanoparticles can be used for targeted radiotherapy, either as sensitizers of external beams or as delivery vehicles for therapeutic radionuclides. We describe the clinical relevance of different types of nanoparticles, followed by an analysis of how these nanoconstructs can solve some of the main limitations of conventional radiotherapy. Finally, we critically discuss the current situation of nanoparticle-based radiotherapy in clinical settings and challenges that need to be overcome in the future for further development of the field.

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Metallic nanoparticles irradiated by low‐energy protons for radiation therapy: Are there significant physical effects to enhance the dose delivery?

Abstract: Although effects from a physical standpoint are limited, the high linear energy transfer profile at the nanoparticle surface generates detrimental events in the cell, in particular ROS-induced damage and local heating.

Cited by 26 publications

References 49 publications

Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient

Gold Nanoparticles as a Potent Radiosensitizer: A Transdisciplinary Approach from Physics to Patient

Recent Advances in Cancer Therapy Based on Dual Mode Gold Nanoparticles

Nanoparticles for targeted cancer radiotherapy

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