Metallic Biomaterials in Tissue Engineering: Retrospect and Prospects

Chowdhury, Suvro Kanti; Nagarjuna, Vasagiri; Bhaskar, Birru

doi:10.1007/978-981-16-0002-9_2

Cited by 3 publications

(2 citation statements)

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“…Biomimetic biomaterials with similar properties to the extracellular matrix play a crucial role in cell proliferation and differentiation, and consequently tissue regeneration. Generally, biomaterials used in tissue engineering can be divided into four main categories: metal-based, ceramic-based, polymer-based, and their composites [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Due to their structure and similarity to the extracellular matrix of hard tissues (such as bone and teeth), bioceramics have been widely investigated for their potential application in the regeneration of hard tissues [ 31 , 32 ]; however, by contrast, there has been limited research into their application in soft tissue regeneration [ 33 , 34 , 35 ], which is in part due to challenges related to engineering bioceramics with mechanical properties mimicking the natural tissues in which they will be implanted [ 24 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

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Lithium (Li) is a metal with critical therapeutic properties ranging from the treatment of bipolar depression to antibacterial, anticancer, antiviral and pro-regenerative effects. This element can be incorporated into the structure of various biomaterials through the inclusion of Li chloride/carbonate into polymeric matrices or being doped in bioceramics. The biocompatibility and multifunctionality of Li-doped bioceramics present many opportunities for biomedical researchers and clinicians. Li-doped bioceramics (capable of immunomodulation) have been used extensively for bone and tooth regeneration, and they have great potential for cartilage/nerve regeneration, osteochondral repair, and wound healing. The synergistic effect of Li in combination with other anticancer drugs as well as the anticancer properties of Li underline the rationale that bioceramics doped with Li may be impactful in cancer treatments. The role of Li in autophagy may explain its impact in regenerative, antiviral, and anticancer research. The combination of Li-doped bioceramics with polymers can provide new biomaterials with suitable flexibility, especially as bio-ink used in 3D printing for clinical applications of tissue engineering. Such Li-doped biomaterials have significant clinical potential in the foreseeable future.

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Section: Introductionmentioning

confidence: 99%

Li-Doped Bioactive Ceramics: Promising Biomaterials for Tissue Engineering and Regenerative Medicine

Farmani

Salmeh

Golkar

et al. 2022

JFB

View full text Add to dashboard Cite

show abstract

“…However, nickel has proven to be a serious health hazard [9]. Accumulation of nickel in the body through chronic exposure to Ni-containing superelastic alloys can lead to Ni hypersensitivity and contact dermatitis [10,11]. In order to take advantage of superelasticity but avoiding the Ni sensitivity issues, development of Ni-free biomedical superelastic alloys has become a research hot spot in recent years [12,13].…”

Section: Introductionmentioning

confidence: 99%